Microbe Species Information

General Information of This Microbe species
Species ID	MIC00028
Species Name	Escherichia coli
Taxonomy ID	562
Lineage	Kingdom:Bacteria Phylum:Pseudomonadota Class:Gammaproteobacteria Order:Enterobacterales Family:Enterobacteriaceae Genus: Escherichia Species: Escherichia coli

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
ATP7A	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
ATP7B	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
CACNA1A	Transporter Info	Health [ICD11: N.A]	[5], [6]
CNT1	Transporter Info	Health [ICD11: N.A]	[7]
CNT2	Transporter Info	Health [ICD11: N.A]	[7]
CNT3	Transporter Info	Health [ICD11: N.A]	[7]
COPT2	Transporter Info	Health [ICD11: N.A]	[1], [2], [4], [8]
CTR1	Transporter Info	Health [ICD11: N.A]	[1], [2], [4], [8]
FLVCR1	Transporter Info	Health [ICD11: N.A]	[9], [10], [11], [12]
IREG1	Transporter Info	Health [ICD11: N.A]	[5], [6]
MRP4	Transporter Info	Health [ICD11: N.A]	[13]
NRAMP2	Transporter Info	Health [ICD11: N.A]	[6], [14], [15], [16]
OAT2	Transporter Info	Health [ICD11: N.A]	[13]
OAT3	Transporter Info	Health [ICD11: N.A]	[13]
OAT4	Transporter Info	Health [ICD11: N.A]	[13]
OATP1A2	Transporter Info	Health [ICD11: N.A]	[13]
PEPT1	Transporter Info	Health [ICD11: N.A]	[17]
PEPT2	Transporter Info	Health [ICD11: N.A]	[18]
SLC11A1	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
SLC25A28	Transporter Info	Health [ICD11: N.A]	[24], [25], [16], [6]
SLC25A37	Transporter Info	Health [ICD11: N.A]	[5], [6]
SLC41A1	Transporter Info	Health [ICD11: N.A]	[26], [27], [28]
SLC48A1	Transporter Info	Health [ICD11: N.A]	[9], [10], [11], [12]
SLC49A2	Transporter Info	Health [ICD11: N.A]	[9], [10], [11], [12]
SLC58A1	Transporter Info	Health [ICD11: N.A]	[26], [27], [28]
ZIP1	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP11	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP12	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP13	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP2	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP3	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP4	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP5	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP7	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZIP8	Transporter Info	Health [ICD11: N.A]	[5], [6]
ZIP9	Transporter Info	Health [ICD11: N.A]	[29], [30], [31]
ZNT1	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
ZNT10	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
ZNT2	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
ZNT3	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
ZNT4	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
ZNT5	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
ZNT6	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
ZNT7	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
ZNT8	Transporter Info	Health [ICD11: N.A]	[29], [34], [31]
ZNT9	Transporter Info	Health [ICD11: N.A]	[29], [32], [33], [31]
Class3: Microbiota regulating the expression and function of DT via the biotransformation of exogenous substances
ABCC7	Transporter Info	Mastitis [ICD11: GB21]	[35]
ASCT1	Transporter Info	Mastitis [ICD11: GB21]	[35]
DAT1	Transporter Info	Watery diarrhea [ICD11: ME05.1]	[36], [37], [38]
GLUT1	Transporter Info	Mastitis [ICD11: GB21]	[35]
SGLT1	Transporter Info	Watery diarrhea [ICD11: ME05.1]	[36], [39], [40]
SLC27A3	Transporter Info	Mastitis [ICD11: GB21]	[35]
ZIP10	Transporter Info	Health [ICD11: N.A]	[41]
ZIP14	Transporter Info	Health [ICD11: N.A]	[31], [42]
ZIP6	Transporter Info	Health [ICD11: N.A]	[31], [42]
Class4: Microbiota regulating the expression and function of DT via other mechanisms
BCRP	Transporter Info	Colon cancer [ICD11: 2B90]	[43]
MRP2	Transporter Info	Colon cancer [ICD11: 2B90]	[43]
NKCC1	Transporter Info	Diarrhea associated with infection by invasive enteric pathogens [ICD11: 1A03]	[36], [44]
OAT1	Transporter Info	Colon cancer [ICD11: 2B90]	[43]
OATP2B1	Transporter Info	Health [ICD11: N.A]	[45], [46]
P-GP	Transporter Info	Colon cancer [ICD11: 2B90]	[43]
SLC9A2	Transporter Info	Diarrhea associated with infection by enteropathogenic Escherichia coli [ICD11: 1A03]	[36], [47]
SLC9A3	Transporter Info	Diarrhea associated with infection by enteropathogenic Escherichia coli [ICD11: 1A03]	[36], [47]

Species Relative Abundances of This Microbe species

References
1	Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper. Anim Nutr. 2021 Sep;7(3):750-761.
2	Cu Homeostasis in Bacteria: The Ins and Outs. Membranes (Basel). 2020 Sep 18;10(9):242.
3	One gene, two proteins: coordinated production of a copper chaperone by differential transcript formation and translational frameshifting in Escherichia coli. Mol Microbiol. 2017 Nov;106(4):635-645.
4	Human copper transporters: mechanism, role in human diseases and therapeutic potential. Future Med Chem. 2009 Sep;1(6):1125-42.
5	The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16502-7.
6	Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
7	Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes. Mol Membr Biol. 2004 Jan-Feb;21(1):1-10.
8	Copper import in Escherichia coli by the yersiniabactin metallophore system. Nat Chem Biol. 2017 Sep;13(9):1016-1021.
9	Sequestration and scavenging of iron in infection. Infect Immun. 2013 Oct;81(10):3503-14.
10	Haem iron-transport system in enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol. 1997 Feb;23(4):825-33.
11	Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res. 2016 Jun 21;49(6):1104-10.
12	Handling heme: The mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019 Mar;133:88-100.
13	Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature. 2017 May 18;545(7654):299-304.
14	Iron metabolism in pathogenic bacteria. Annu Rev Microbiol. 2000;54:881-941.
15	Relative availability of transferrin-bound iron and cell-derived iron to aerobactin-producing and enterochelin-producing strains of Escherichia coli and to other microorganisms. Infect Immun. 1991 Sep;59(9):3185-90.
16	Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence. Front Cell Infect Microbiol. 2013 Dec 5;3:90.
17	DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli. FEBS J. 2008 Jul;275(13):3290-8.
18	Projection structure of DtpD (YbgH), a prokaryotic member of the peptide transporter family. J Mol Biol. 2009 Dec 11;394(4):708-17.
19	Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
20	The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen. Mol Microbiol. 2000 Jun;36(5):1085-100.
21	Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter. Mol Microbiol. 2000 Mar;35(5):1065-78.
22	Human iron transporters. Genes Nutr. 2011 Feb;6(1):45-54.
23	Iron transport machinery of human cells: players and their interactions. Curr Top Membr. 2012;69:67-93.
24	Bacterial ferrous iron transport: the Feo system. FEMS Microbiol Rev. 2016 Mar;40(2):273-98.
25	A new ferrous iron-uptake transporter, EfeU (YcdN), from Escherichia coli. Mol Microbiol. 2006 Oct;62(1):120-31.
26	The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro. Elife. 2016 Jan 18;5:e11407.
27	The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):620-8.
28	The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. J Biol Chem. 1999 Jul 16;274(29):20438-43.
29	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
30	The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli. Mol Microbiol. 1998 Jun;28(6):1199-210.
31	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.
32	Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7202-7.
33	Selective metal binding to a membrane-embedded aspartate in the Escherichia coli metal transporter YiiP (FieF). J Biol Chem. 2005 Oct 7;280(40):33716-24.
34	ZupT is a Zn(II) uptake system in Escherichia coli. J Bacteriol. 2002 Feb;184(3):864-6.
35	Underlying mechanisms involved in the decrease of milk secretion during Escherichia coli endotoxin induced mastitis in lactating mice. Vet Res. 2013 Dec 5;44(1):119.
36	The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018 Mar 5;6(1):33-45.
37	Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea. Nat Rev Microbiol. 2009 Feb;7(2):110-9.
38	Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. J Clin Invest. 2007 Feb;117(2):428-37.
39	Infectious diarrhea: Cellular and molecular mechanisms. Gut Microbes. 2010 Jan;1(1):4-21.
40	Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1876-81.
41	Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12940-12945.
42	Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A. 2005 May 10;102(19):6843-8.
43	Causative Role of Anoxic Environment in Bacterial Regulation of Human Intestinal Function. Cell Mol Bioeng. 2022 Sep 16;15(5):493-504.
44	Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. Gastroenterology. 2002 Apr;122(4):1070-87.
45	The influence of the gut microbiota on the bioavailability of oral drugs. Acta Pharm Sin B. 2021 Jul;11(7):1789-1812.
46	Administration of a probiotic can change drug pharmacokinetics: effect of E. coli Nissle 1917 on amidarone absorption in rats. PLoS One. 2014 Feb 5;9(2):e87150.
47	Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2004 Aug;287(2):G370-8.

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