Download the Distribution Variability Data and the Updated Comprehensive Data of DT (4.0)

a. Tissue Distribution Level of DTs
    Tissue-Level Transcriptomic Expression of DTs Click to Save
    Tissue-Level Proteomic Expression of DTs Click to Save
b. Cellular Distribution Level of DTs
    Single Cell Transcriptomic Expression of DTs Click to Save
    Cell Line Transcriptomic Expression of DTs Click to Save
    Cell Line Proteomic Expression of DTs Click to Save
c. Subcellular Location of DTs
    Literature-Supported subcellular localization data for DTs Click to Save
    LocPro-Predicted subcellular localization data for DTs Click to Save
d. Update of Previous Versions
    Epigenetic regulation data(DNA_methylation) (3.0 Update) Click to Save
    Epigenetic regulation data(histone_modification) (3.0 Update) Click to Save
    Epigenetic regulation data(noncoding_RNA_regulation) (3.0 Update) Click to Save
    Exogenous factors (medications, biotoxins, mycotoxins, dietary constituents, etc.) altering DT activity (3.0 Update) Click to Save
    Genetic polymorphism data(Allele & minor allele frequency) (1.0 Update) Click to Save
    Genetic polymorphism data (Correlation with phenotype) (1.0 Update) Click to Save
    Microbiota influence data (the detailed mechanism of action / experimental models/ regulation phenomenons) (3.0 Update) Click to Save
    Post-translational modification data (modification types / amino acid residue modification sites / related DT & drugs variation) (3.0 Update) Click to Save
    Disease-specific protein abundances (181 diseases and 105 tissues) (1.0 Update) Click to Save
    Mutation and Crystal Structure of DTs (2.0 Update) Click to Save
    Mutation and Closely Related Crystal Structures of DTs (2.0 Update) Click to Save
    Crystal Structures of DTs (2.0 Update) Click to Save
    Transcription Factor Interaction of DTs (3.0 Update) Click to Save
    Conformational Diversity of DTs (2.0 Update) Click to Save
    Model Organisms for DTs Research and Closely Related DT Structures (2.0 Update) Click to Save

Download the Regulatory Variability Data of DT (3.0)

a. Microbiota influence (MBI) of DTs
    Microbe species info (the complete species lineage) Click to Save
    Microbiota influence data (the detailed mechanism of action / experimental models/ regulation phenomenons) Click to Save
b. Post-translational modification (PTM) of DTs
    Post-translational modification data (modification types / amino acid residue modification sites / related DT & drugs variation) Click to Save
c. Transcriptional regulation (TSR) of DTs
    Family and function data for each TF Click to Save
    Disease-specific protein abundances of TF Click to Save
    Transcriptional regulation data (activation / regression / direct binding, etc.) Click to Save
d. Epigenetic regulation (EGR) of DTs
    Epigenetic regulation data (DNA methylation) Click to Save
    Epigenetic regulation data (Noncoding RNA regulation) Click to Save
    Epigenetic regulation data (Histone modification) Click to Save
e. Exogenous modulation (EGM) of DTs
    Exogenous factors (medications, biotoxins, mycotoxins, dietary constituents, etc.) altering DT activity Click to Save

Download the Structural Variability Data of DT (2.0)

Drug Transporters (DTs)
    Sequence (FASTA format) and structure (PDB file) data of DTs Click to Save
    Transporter-drug affinity data based on cell line experiment Click to Save
    Functional family data for each DT Click to Save
Drugs Transported by DTs
    2D structure data (SDF format) for the drugs transported by DTs Click to Save
    3D structure data (SDF format) for the drugs transported by DTs Click to Save
    SMILES and InChI for the drugs transported by DTs Click to Save
    Therapeutic classes and physicochemical properties for the drugs Click to Save
Endogenous Metabolites (EMs) Handled by DTs
    EMs handled by DTs identified using KO mice / cell lines / patient clinical data Click to Save
    2D structure data (SDF format) for the EMs handled by DTs Click to Save
    3D structure data (SDF format) for the EMs handled by DTs Click to Save
    SMILES and InChI for the EMs handled by DTs Click to Save
    Physicochemical properties for EMs Click to Save
Synonyms and Cross-matching
    Cross-matching ID between the DTs and a variety of public databases Click to Save
    Synonyms of DTs and their corresponding drugs Click to Save
    DTs to disease mapping with International Classification of Diseases (ICD) identifiers Click to Save
    Drug to disease mapping with International Classification of Diseases (ICD) identifiers Click to Save

Download the General Variability Data of DT (1.0)

a. Genetic Polymorphisms of DTs
    Genetic polymorphism data (Allele & minor allele frequency) Click to Save
    Genetic polymorphism data (Correlation with phenotype) Click to Save
b. Disease-specific Protein Abundances of DT
    Disease-specific protein abundances (108 diseases and 61 tissues) Click to Save
c. Species/Tissue-specific Protein Abundances of DT
    Species-specific protein abundances (model organisms) Click to Save
    Tissue-specific protein abundances (36 human tissues) Click to Save

Last Update by

    Aug 26, 2025

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