Dr. Feng ZHU

Professor, Doctoral advisor, H-index & My Citations (Google Scholar)

Vice President of Youth Committee of CNPHARS Analytical Pharmacology and Chongqing Bioinformatics Society; Member of Analytical Pharmacology Committee of CNPHARS, Computational Chemistry Committee of CCS and Task Force on Bioinformatics Committee of CCF

zhufeng@zju.edu.cn (primary), prof.zhufeng@gmail.com; +86-571-88208444

Medicinal Chemistry, Drug Design, Target Discovery, Bioinformatics and System Biology

Based on the artificial intelligence and OMIC (proteomics and metabolomics) technologies, we conduct systematical exploration on the druggability and system profile of therapeutic drug targets, develop novel methods and online tools for target discovery, and further study the mechanism underlying the interaction between drugs and their corresponding targets.

Project on going

2019.01 - (PI): National Natural Science Foundation of China - The General Program (81872798)

2018.09 - (PP): National Key Research and Development Program of China (2018YFC0910500)

2018.01 - (PI): Zhejiang University Youth Research Innovation Grant (2018QNA7023)

2017.07 - (PI): Zhejiang University "100-Plan Professor" Grant (ZJU2017070)

2016.08 - (PI): National Key Research and Development Program of China (2016YFC0902200)

2015.12 - (PI): Chongqing Special Funds for (Chemical) Drug Discovery (cstc2015zdcy-ztzx120003)

Project finished

2014.06 - (PI): International Recruitment Program (Youth) of China (IRPC-Y-CQU2014-ZF)

2014.06 - (PI): Fundamental Research Funds for the Central Universities (CDJZR14 46 88 01, evaluated as "Excellent")

2013.01 - (PI): Fundamental Research Funds for the Central Universities (CQDXWL-2012-Z003, evaluated as "Excellent")

2013.01 - (PI): National Natural Science Foundation of China - The Youth Program (81202459)

2012.09 - (PI): Chongqing Natural Science Foundation (cstc2012jjA10116)

2012.08 - (PP): Tianjin Key Technology Support Program (tjkjzc2013zd01)

2012.07 - (PI): Youth 100 Talents Program of Chongqing University (0903005203176, evaluated as "Excellent")

PI: Principal Investigator; PP: Project Participant.

*corresponding author; highlighted graphic abstract

1. Q. X. Yang, B. Li, J. Tang, X. J. Cui, Y. X. Wang, X. F. Li, J. Hu, Y. Z. Chen, W. W. Xue, Y. Lou, Y. Q. Qiu*, F. Zhu*. Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). doi: 10.1093/bib/bbz049 (2019).
2. J. Tang, J. B. Fu, Y. X. Wang, Y. C. Luo, Q. X. Yang, B. Li, G. Tu, J. J. Hong, X. J. Cui, Y. Z. Chen, L. X. Yao, W. W. Xue, F. Zhu*. Simultaneous improvement in the precision, accuracy and robustness of label-free proteome quantification by optimizing data manipulation chains. Mol Cell Proteomics (impact factor of the publication year: 5.236, 生物二区期刊). 18(8): 1683-1699 (2019).
3. Y. H. Li, X. X. Li, J. J. Hong, Y. X. Wang, J. B. Fu, H. Yang, C. Y. Yu, F. C. Li, J. Hu, W. W. Xue, Y. Y. Jiang, Y. Z. Chen*, F. Zhu*. Clinical trials, progression-speed differentiating features, and swiftness rule of the innovative targets of first-in-class drugs. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). doi: 10.1093/bib/bby130 (2019).
4. J. J. Hong, Y. C. Luo, Y. Zhang, J. B. Ying, W. W. Xue, T. Xie, L. Tao*, F. Zhu*. Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). doi: 10.1093/bib/bbz081 (2019).
5. J. Tang, J. B. Fu, Y. X. Wang, B. Li, Y. H. Li, Q. X. Yang, X. J. Cui, J. J. Hong, X. F. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. ANPELA: analysis and performance-assessment of the label-free quantification workflow for metaproteomic studies. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). doi: 10.1093/bib/bby127 (2019).
6. Y. Zhang, J. B. Ying, J. J. Hong, F. C. Li, T. T. Fu, F. Y. Yang, G. X. Zheng, X. J. Yao, Y. Lou, Y. Q. Qiu, W. W. Xue*, F. Zhu*. How does chirality determine the selective inhibition of histone deacetylase 6? A lesson from Trichostatin A enantiomers based on molecular dynamics. ACS Chem Neurosci (impact factor of the publication year: 4.211, 化学二区 TOP 期刊). 10(5): 2467-2480 (2019).

Cover Article:

• The Cover Article of ACS Chem Neurosci 2019 10(5), Download the Cover HERE.

7. Y. H. Li, C. Y. Yu, X. X. Li, P. Zhang, J. Tang, Q. X. Yang, T. T. Fu, X. Y. Zhang, X. J. Cui, G. Tu, Y. Zhang, S. Li, F. Y. Yang, Q. Sun, C. Qin, X. Zeng, Z. Chen, Y. Z. Chen*, F. Zhu*. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. Nucleic Acids Res (impact factor of the publication year: 11.561, 生物一区 TOP 期刊). 46(D1): 1121-1127 (2018).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.16% in 2019.
• The Percentile in Subject Area shown in InCites™ was 0.36% in 2018.

Highlights by Experts in Subject Area:

• Introduced by OMICTOOLS as "useful for facilitating patient focused research, discovery and clinical investigations of the targeted therapeutics".

8. F. Zhu*, X. X. Li, S. Y. Yang, Y. Z. Chen*. The clinical success of drug targets prospectively predicted by the in-silico study. Trends Pharmacol Sci (impact factor of the publication year: 12.797, 医学一区 TOP 期刊). 39(3): 229-231 (2018).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.10% in 2019.
• The Percentile in Subject Area shown in InCites™ was 0.21% in 2018.

9. W. W. Xue, F. Y. Yang, P. P. Wang, G. X. Zheng, Y. Z. Chen, X. J. Yao, F. Zhu*. What contributes to serotonin-norepinephrine reuptake inhibitors' dual-targeting mechanism? The key role of transmembrane domain 6 in human serotonin and norepinephrine transporters revealed by molecular dynamics simulation. ACS Chem Neurosci (impact factor of the publication year: 4.211, 化学二区 TOP 期刊). 9(5): 1128-1140 (2018).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.29% in 2019.
• The Percentile in Subject Area shown in InCites™ was 1.11% in 2018.

10. F. Y. Yang, G. X. Zheng, T. T. Fu, X. F. Li, G. Tu, Y. H. Li, X. J. Yao, W. W. Xue*, F. Zhu*. Prediction of binding mode and resistance profile for dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase associated ribonuclease H. Phys Chem Chem Phys (impact factor of the publication year: 4.123, 化学二区 TOP 期刊). 20(37): 23873-23884 (2018).

Back Cover Article:

• The Back Cover Article of Phys Chem Chem Phys 2018 20(37), Download the Cover HERE.

11. Z. J. Han, W. W. Xue, L. Tao, F. Zhu*. Identification of novel immune-relevant drug target genes for alzheimer's disease by combining ontology inference with network analysis. CNS Neurosci Ther (impact factor of the publication year: 3.495, 医学二区期刊). 24(12): 1253-1263 (2018).

Cover Article:

• The Cover Article of CNS Neurosci Ther 2018 24(12), Download the Cover HERE.

12. B. Li, J. Tang, Q. X. Yang, S. Li, X. J. Cui, Y. H. Li, Y. Z. Chen, W. W. Xue, X. F. Li, F. Zhu*. NOREVA: normalization and evaluation of MS-based metabolomics data. Nucleic Acids Res (impact factor of the publication year: 10.162, 生物一区 TOP 期刊). 45(W1): 162-170 (2017).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 1.27% in 2019.
• The Percentile in Subject Area shown in InCites™ was 2.98% in 2018.

Highlights by Experts in Subject Area:

• Introduced by OMICTOOLS as "provided valuable guidance to the selection of suitable algorithm in metabolomics".
• Discussed in StackExchange as "works fine" and "corrections for batches without QC options".

13. P. P. Wang, X. Y. Zhang, T. T. Fu, S. Li, B. Li, W. W. Xue*, X. J. Yao, Y. Z. Chen, F. Zhu*. Differentiating physicochemical properties between addictive and nonaddictive ADHD drugs revealed by molecular dynamics simulation studies. ACS Chem Neurosci (impact factor of the publication year: 4.348, 化学二区 TOP 期刊). 8(6): 1416-1428 (2017).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 1.32% in 2019.

14. H. Yang, C. Qin, Y. H. Li, L. Tao, J. Zhou, C. Y. Yu, F. Xu, Z. Chen, F. Zhu*, Y. Z. Chen*. Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information. Nucleic Acids Res (impact factor of the publication year: 9.202, 生物一区 TOP 期刊). 44(D1): 1069-1074 (2016).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.66% in 2019.
• The Percentile in Subject Area shown in InCites™ was 0.71% in 2018.
• The Percentile in Subject Area shown in InCites™ was 0.87% in 2017.

15. F. Zhu, Z. Shi, C. Qin, L. Tao, X. Liu, F. Xu, L. Zhang, Y. Song, X. H. Liu, J. X. Zhang, B. C. Han, P. Zhang, Y. Z. Chen*. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (impact factor of the publication year: 8.026, 生物一区 TOP 期刊). 40(D1): 1128-1136 (2012).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.60% in 2019.
• The Percentile in Subject Area shown in InCites™ was 0.62% in 2018.
• The Percentile in Subject Area shown in InCites™ was 0.31% in 2017.

Highlights by Experts in Subject Area:

• "FACULTYof1000" as "the top 2% of published articles in biology and medicine" and "a most useful resource for scientists and companies working on drug discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations".
• Prof. Chris Southan in his blog as "Therapeutic Target Database in PubChem".

16. F. Zhu, C. Qin, L. Tao, X. Liu, Z. Shi, X. H. Ma, J. Jia, Y. Tan, C. Cui, J. S. Lin, C. Y. Tan, Y. Y. Jiang*, Y. Z. Chen*. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A (impact factor of the publication year: 9.432, 综合性一区 TOP 期刊). 108(31): 12943-12948 (2011).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.94% in 2019.
• The Percentile in Subject Area shown in InCites™ was 1.16% in 2018.
• The Percentile in Subject Area shown in InCites™ was 1.91% in 2017.

Highlights by Experts in Subject Area:

• "It Takes 30" of Department of System Biology @ Harvard Medical School as "Drugs run in families".
• International Cooperative Biodiversity Groups as "Highlighted literature citations for Aug 2011".

Media Coverage & News Report:

• NEWS MEDICAL. Sep 8th, 2011.
• Medical News Today (MNT). Sep 7th, 2011.
• mediLexicon.com. Sep 7th, 2011.
• BrightSurf.com. Sep 7th, 2011.
• SCIENCE CODEX. Sep 6th, 2011.
• Sciencenewsline biology. Sep 6th, 2011.
• MedicalXpress. Sep 6th, 2011.
• FirstScience News. Sep 6th, 2011.
• Labspaces.net. Sep 6th, 2011.
• EurekAlert. Sep 6th, 2011.
• eBioNews. Sep 1st, 2011.
• ScienceDaily. Aug 31st, 2011.
• HealthCanal.com. Aug 31st, 2011.
• News Ecology. Aug 31st, 2011.

17. F. Zhu, B. C. Han, P. Kumar, X. H. Liu, X. H. Ma, X. N. Wei, L. Huang, Y. F. Guo, L. Y. Han, C. J. Zheng, Y. Z. Chen*. Update of TTD: therapeutic target database. Nucleic Acids Res (impact factor of the publication year: 7.479, 生物一区 TOP 期刊). 38(D1): 787-791 (2010).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 2.95% in 2017.

18. F. Zhu, L. Y. Han, C. J. Zheng, B. Xie, M. T. Tammi, S. Y. Yang, Y. Q. Wei, Y. Z. Chen*. What are next generation innovative therapeutic targets? Clues from genetic, structural, physicochemical and system profile of successful targets. J Pharmacol Exp Ther (impact factor of the publication year: 3.867, 医学二区 TOP 期刊). 330(1): 304-315 (2009).

Successful Validation of the Constructed Model:

• Pasireotide targeting Somatostatin receptor 1 was approved by FDA in 2011.
• Fingolimod targeting S1P receptor was approved by FDA in 2010.
• Ecallantide targeting Plasma Kallikrein was approved by FDA in 2009.
• Cinryze targeting C1 esterase was approved by FDA in 2009.
• Icatibant targeting BK-2 receptor was approved by FDA in 2008.
• Plerixafor targeting CXCR4 was approved by FDA in 2008.

Vice-chairman of the Symposium 24 Session-4 for The 31st Academic Annual Conference of the Chinese Chemical Society. Zhejiang University, Hangzhou, P. R. China (2018)

Chairman of the Symposium IV Session -7 (metabonomics) for Asian Federation for Pharmaceutical Sciences Conference 2017. Xiamen University, Xiamen, P. R. China (2017)

Member of the Academic Committee for The 14th National Symposium of Computer & Computational Chemistry. Nanjing University, Nanjing, P. R. China (2017)

Member of the Academic Committee for The Second CCF Bioinformatics Conference (CBC-2017). Central South University, Changsha, P. R. China (2017)

Chairman of the sub-conference 103 (multi-target and protein-protein interaction) for BIT’s 6th Annual International Congress of Medichem-2016 (ICM-2016) . China Pharmaceutical University, Nanjing, P. R. China. (2016)

Vice-chairman of the 6th theme (study on drug transporter and PK/PD) for BIT’s 6th Annual International Congress of Medichem-2016 (ICM-2016) . China Pharmaceutical University, Nanjing, P. R. China. (2016)

Chair of the Organizing Committee and the Member of the Academic Committee for The 2nd Symposium on Bioinformatics and Drug Design. Chongqing University, Chongqing, P. R. China. (2016)

Member of the Academic Committee for The 13th National Symposium of Computer & Computational Chemistry. Sun Yat-sen University, Guangzhou, P. R. China. (2015)

Member of the Organizing Committee for International Symposium on Natural Product Synthesis and Innovative Process Methods for Drug Manufacture. Chongqing University, Chongqing, P. R. China. (2012)

Keynote Speaker
• 1st West Lake Clinical Research and Evaluation Conference and Annual Conference of the Clinical Trial Committee of Zhejiang Pharmaceutical Association. The First Affiliated Hospital, Zhejiang University, Hangzhou, China (2018)
• 11th China-Japan Symposium on Molecular Drug Design and Development. Zhejiang University and Peking Union Medical College, Chinese Academy of Medical Sciences, Shaoxing, China (2018)
• 2017 Symposium on Pharmaceutical Chemistry of the Yangtze River Delta Metropolitan Region. Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, China (2017)

Invited Speaker
• International Conference on Artificial Intelligence and Biomedicine. Taizhou University, Taizhou, P. R. China (2019)
• Jiangsu-Zhejiang International Symposium of Bioinformatics. Jiangnan University, Wuxi, P. R. China (2019)
• 3rd Conference for Analytical Pharmacology of CNPHARS. Zunyi Medical University, Zuiyi, P. R. China (2018)
• 10th National Symposium of Genetics Society of China. Nanjing Agricultural University, Nanjing, China (2018)
• 14th Symposium of the CPA Youth Pharmacologist. Chinese Pharmaceutical Association, Hangzhou, China (2018)
• 2nd Worldwide Computational Biology and Molecular Simulation Conference. Sun Yat-sen University, Guangzhou, China (2018)
• 31st Academic Annual Conference of the Chinese Chemical Society. Zhejiang University, Hangzhou, China (2018)
• Asian Federation for Pharmaceutical Sciences Conference 2017. Xiamen University, Xiamen, China (2017)
• 14th National Symposium of Computer & Computational Chemistry. Nanjing University, Nanjing, China (2017)
• 5th Academic Forum for Postgraduates. Sichuan University, Chengdu, China (2017)
• 2nd Conference on Innovative Drug Research and Application. Nanjing Biotech and Pharmaceutical Valley, Nanjing, China (2017)
• Bioinformatics and Intelligent Information Processing Conference. Shanghai Jiao Tong University, Shanghai, China (2017)
• Fifth Young Scholars Forum for Interdisciplinary Researches. Chinese Academy of Sciences, Beijing, China (2017)
• 2017 (the second) Conference on Precision and Future Medicine. Zhejiang University, Hangzhou, China (2017)
• China Society of Biotechnology Young Scientists Forum II . South China University of Technology, Guangzhou, China (2017)
• 2016 Symposium of Guanghua Young Distinguished Scholars . Fudan University, Shanghai, China (2016)
• BIT’s 6th Annual International Congress of Medichem-2016. China Pharmaceutical University, Nanjing, China (2016)
• 1st International Symposium on Targeted Therapeutics. Chongqing University of Arts and Sciences, Chongqing, China (2016)
• 4th International Conference on Molecular Simulation. Shanghai Jiao Tong University, Shanghai, China (2016)
• 7th National Conference on Bioinformatics. University of Electronic Science and Technology of China, Chengdu, China (2016)
• 2016 Conference on Precision Medicine. Xian Jiaotong University, Xian, China (2016)
• 12th Sino-US Chemistry Professors Conference. Sun Yat-sen University, Guangzhou, China (2016)
• 2016 Symposium of International Young Distinguished Scholars. Tongji University, Shanghai, China (2016)
• 2nd Symposium on Bioinformatics and Drug Design. Chongqing University, Chongqing, China (2016)
• 2016 Conference on Bioinformatics and Intelligent Information Processing. Jilin University, Jilin, China (2016)
• 30th Academic Annual Conference of the Chinese Chemical Society. Dalian University of Technology, Dalian, China (2016)
• 2016 Academic Salon of Shanghai Society for Bioinformatics. Fudan University, Shanghai, China (2016)
• 2016 Symposium of Big Data and Precision Biomedical Informatics. Shanghai Jiao Tong University, Shanghai, China (2016)
• 13th National Symposium of Computer & Computational Chemistry. Sun Yat-sen University, Guangzhou, China (2015)
• 6th International Conference of Molecular Simulation. China Pharmaceutical University, Nanjing, China (2012)