- J. Y. Yin, F. C. Li, Y. Zhou, M. J. Mou, Y. J. Lu, K. L. Chen, J. Xue, Y. C. Luo, J. B. Fu, X. He, J. Q. Gao, S. Zeng*, L. S. Yu*, F. Zhu*. INTEDE: interactome of drug-metabolizing enzymes. Nucleic Acids Res (impact factor of the publication year: 11.501, 生物一区 TOP 期刊). 49(D1): 1233-1243 (2021).
Media Coverage & News Report:
- J. Tang, X. L. Wu, M. J. Mou, C. Wang, L. D. Wang, F. C. Li, M. Y. Guo, J. Y. Yin, W. Q. Xie, X. N. Wang, Y. X. Wang, Y. B. Ding*, W. W. Xue*, F. Zhu*. GIMICA: host genetic and immune factors shaping human microbiota. Nucleic Acids Res (impact factor of the publication year: 11.501, 生物一区 TOP 期刊). 49(D1): 715-722 (2021).
Media Coverage & News Report:
- Y. X. Wang, S. Zhang, F. C. Li, Y. Zhou, Y. Zhang, Z. W. Wang, R. Y. Zhang, J. Zhu, Y. X. Ren, Y. Tan, C. Qin, Y. H. Li, X. X. Li, Y. Z. Chen*, F. Zhu*. Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. Nucleic Acids Res (impact factor of the publication year: 11.501, 生物一区 TOP 期刊). 48(D1): 1031-1041 (2020).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.15% in 2021.
Media Coverage & News Report:
- Q. X. Yang, Y. X. Wang, Y. Zhang, F. C. Li, W. Q. Xia, Y. Zhou, Y. Q. Qiu, H. L. Li, F. Zhu*. NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data. Nucleic Acids Res (impact factor of the publication year: 11.501, 生物一区 TOP 期刊). 48(W1): 436-448 (2020).
Media Coverage & News Report:
- J. Y. Yin, W. Sun, F. C. Li, J. J. Hong, X. X. Li, Y. Zhou, Y. J. Lu, M. Z. Liu, X. Zhang, N. Chen, X. P. Jin, J. Xue, S. Zeng*, L. S. Yu*, F. Zhu*. VARIDT 1.0: variability of drug transporter database. Nucleic Acids Res (impact factor of the publication year: 11.501, 生物一区 TOP 期刊). 48(D1): 1042-1050 (2020).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.33% in 2021.
Media Coverage & News Report:
- Y. H. Li, C. Y. Yu, X. X. Li, P. Zhang, J. Tang, Q. X. Yang, T. T. Fu, X. Y. Zhang, X. J. Cui, G. Tu, Y. Zhang, S. Li, F. Y. Yang, Q. Sun, C. Qin, X. Zeng, Z. Chen, Y. Z. Chen*, F. Zhu*. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. Nucleic Acids Res (impact factor of the publication year: 11.561, 生物一区 TOP 期刊). 46(D1): 1121-1127 (2018).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.15% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.14% in 2020.
- The Percentile in Subject Area shown in InCites™ was 0.16% in 2019.
- The Percentile in Subject Area shown in InCites™ was 0.36% in 2018.
Highlights by Experts in Subject Area:
- Introduced by OMICTOOLS as "useful for facilitating patient focused research, discovery and clinical investigations of the targeted therapeutics".
B. Li, J. Tang, Q. X. Yang, S. Li, X. J. Cui, Y. H. Li, Y. Z. Chen, W. W. Xue, X. F. Li, F. Zhu*. NOREVA: normalization and evaluation of MS-based metabolomics data. Nucleic Acids Res (impact factor of the publication year: 10.162, 生物一区 TOP 期刊). 45(W1): 162-170 (2017).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.72% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.75% in 2020.
- The Percentile in Subject Area shown in InCites™ was 1.27% in 2019.
- The Percentile in Subject Area shown in InCites™ was 2.98% in 2018.
Highlights by Experts in Subject Area:
- Introduced by OMICTOOLS as "provided valuable guidance to the selection of suitable algorithm in metabolomics".
- Discussed in StackExchange as "works fine" and "corrections for batches without QC options".
F. Zhu, Z. Shi, C. Qin, L. Tao, X. Liu, F. Xu, L. Zhang, Y. Song, X. H. Liu, J. X. Zhang, B. C. Han, P. Zhang, Y. Z. Chen*. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (impact factor of the publication year: 8.026, 生物一区 TOP 期刊). 40(D1): 1128-1136 (2012).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.69% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.66% in 2020.
- The Percentile in Subject Area shown in InCites™ was 0.60% in 2019.
- The Percentile in Subject Area shown in InCites™ was 0.62% in 2018.
- The Percentile in Subject Area shown in InCites™ was 0.31% in 2017.
Highlights by Experts in Subject Area:
- "FACULTYof1000" as "the top 2% of published articles in biology and medicine" and "a most useful resource for scientists and companies working on drug discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations".
- Prof. Chris Southan in his blog as "Therapeutic Target Database in PubChem".
F. Zhu, B. C. Han, P. Kumar, X. H. Liu, X. H. Ma, X. N. Wei, L. Huang, Y. F. Guo, L. Y. Han, C. J. Zheng, Y. Z. Chen*. Update of TTD: therapeutic target database. Nucleic Acids Res (impact factor of the publication year: 7.479, 生物一区 TOP 期刊). 38(D1): 787-791 (2010).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 2.95% in 2017.
F. Zhu, C. Qin, L. Tao, X. Liu, Z. Shi, X. H. Ma, J. Jia, Y. Tan, C. Cui, J. S. Lin, C. Y. Tan, Y. Y. Jiang*, Y. Z. Chen*. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A (impact factor of the publication year: 9.432, 综合性一区 TOP 期刊). 108(31): 12943-12948 (2011).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.98% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.90% in 2020.
- The Percentile in Subject Area shown in InCites™ was 0.94% in 2019.
- The Percentile in Subject Area shown in InCites™ was 1.16% in 2018.
- The Percentile in Subject Area shown in InCites™ was 1.91% in 2017.
Highlights by Experts in Subject Area:
Media Coverage & News Report:
- NEWS MEDICAL. Sep 8th, 2011.
- Medical News Today (MNT). Sep 7th, 2011.
- mediLexicon.com. Sep 7th, 2011.
- BrightSurf.com. Sep 7th, 2011.
- SCIENCE CODEX. Sep 6th, 2011.
- Sciencenewsline biology. Sep 6th, 2011.
- MedicalXpress. Sep 6th, 2011.
- FirstScience News. Sep 6th, 2011.
- Labspaces.net. Sep 6th, 2011.
- EurekAlert. Sep 6th, 2011.
- eBioNews. Sep 1st, 2011.
- ScienceDaily. Aug 31st, 2011.
- HealthCanal.com. Aug 31st, 2011.
- News Ecology. Aug 31st, 2011.
J. J. Hong, Y. C. Luo, M. J. Mou, J. B. Fu, Y. Zhang, W. W. Xue, T. Xie, L. Tao*, Y. Lou*, F. Zhu*. Convolutional neural network-based annotation of bacterial type IV secretion system effectors with enhanced accuracy and reduced false discovery. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(5): 1825-1836 (2020).
Y. H. Li, X. X. Li, J. J. Hong, Y. X. Wang, J. B. Fu, H. Yang, C. Y. Yu, F. C. Li, J. Hu, W. W. Xue, Y. Y. Jiang, Y. Z. Chen*, F. Zhu*. Clinical trials, progression-speed differentiating features, and swiftness rule of the innovative targets of first-in-class drugs. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(2): 649-662 (2020).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.08% in 2021.
J. Tang, J. B. Fu, Y. X. Wang, B. Li, Y. H. Li, Q. X. Yang, X. J. Cui, J. J. Hong, X. F. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. ANPELA: analysis and performance-assessment of the label-free quantification workflow for metaproteomic studies. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(2): 621-636 (2020).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.05% in 2021.
Q. X. Yang, B. Li, J. Tang, X. J. Cui, Y. X. Wang, X. F. Li, J. Hu, Y. Z. Chen, W. W. Xue, Y. Lou, Y. Q. Qiu*, F. Zhu*. Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(3): 1058-1068 (2020).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.19% in 2021.
Z. J. Han, W. W. Xue, L. Tao, Y. Lou, Y. Q. Qiu*, F. Zhu*. Genome-wide identification and analysis of the eQTL lncRNAs in multiple sclerosis based on RNA-seq data. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(3): 1023-1037 (2020).
J. Tang, Y. X. Wang, J. B. Fu, Y. Zhou, Y. C. Luo, Y. Zhang, B. Li, Q. X. Yang, W. W. Xue, Y. Lou, Y. Q. Qiu*, F. Zhu*. A critical assessment of the feature selection methods used for biomarker discovery in current metaproteomic studies. Brief Bioinform (当年影响因子: 9.101, 生物一区 TOP 期刊). 21(4): 1378-1390 (2020).
J. J. Hong, Y. C. Luo, Y. Zhang, J. B. Ying, W. W. Xue, T. Xie, L. Tao*, F. Zhu*. Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(4): 1437-1447 (2020).
Q. X. Yang, J. J. Hong, Y. Li, W. W. Xue, S. Li*, H. Yang*, F. Zhu*. A novel bioinformatics approach to identify the consistently well-performing normalization strategy for current metabolomic studies. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(6): 2142-2152 (2020).
Y. X. Wang, F. C. Li, Y, Zhang, Y. Zhou, Y. Tan, Y. Z. Chen*, F. Zhu*. Databases for the targeted COVID-19 therapeutics. Br J Pharmacol (impact factor of the publication year: 7.730, 医学二区 TOP 期刊). 177: 4999-5001 (2020).
J. Tang, Y. X. Wang, Y. C. Luo, J. B. Fu, Y. Zhang, Y. Li, Z. Y. Xiao, Y. Lou, Y. Q. Qiu*, F. Zhu*. Computational advances of tumor marker selection and sample classification in cancer proteomics. Comput Struct Biotechnol J (impact factor of the publication year: 6.018, 生物二区 TOP 期刊). 18: 2012-2025 (2020).
J. Tang, J. B. Fu, Y. X. Wang, Y. C. Luo, Q. X. Yang, B. Li, G. Tu, J. J. Hong, X. J. Cui, Y. Z. Chen, L. X. Yao, W. W. Xue, F. Zhu*. Simultaneous improvement in the precision, accuracy and robustness of label-free proteome quantification by optimizing data manipulation chains. Mol Cell Proteomics (impact factor of the publication year: 5.236, 生物二区 TOP 期刊). 18(8): 1683-1699 (2019).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.81% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.56% in 2020.
F. C. Li, Y. Zhou, X. Y. Zhang, J. Tang, Q. X. Yang, Y. Zhang, Y. C. Luo, J. Hu*, W. W. Xue, Y. Q. Qiu, Q. J. He, B. Yang, F. Zhu*. SSizer: determining the sample sufficiency for comparative biological study. J Mol Biol (impact factor of the publication year: 5.067, 生物二区 TOP 期刊). 432(11): 3411-3421 (2020).
Y. Zhang, J. B. Ying, J. J. Hong, F. C. Li, T. T. Fu, F. Y. Yang, G. X. Zheng, X. J. Yao, Y. Lou, Y. Q. Qiu, W. W. Xue*, F. Zhu*. How does chirality determine the selective inhibition of histone deacetylase 6? A lesson from Trichostatin A enantiomers based on molecular dynamics. ACS Chem Neurosci (impact factor of the publication year: 4.211, 化学二区 TOP 期刊). 10(5): 2467-2480 (2019).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 1.19% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.90% in 2020.
Cover Article:
W. W. Xue, F. Y. Yang, P. P. Wang, G. X. Zheng, Y. Z. Chen, X. J. Yao, F. Zhu*. What contributes to serotonin-norepinephrine reuptake inhibitors' dual-targeting mechanism? The key role of transmembrane domain 6 in human serotonin and norepinephrine transporters revealed by molecular dynamics simulation. ACS Chem Neurosci (impact factor of the publication year: 4.211, 化学二区 TOP 期刊). 9(5): 1128-1140 (2018).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.14% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.21% in 2020.
- The Percentile in Subject Area shown in InCites™ was 0.29% in 2019.
- The Percentile in Subject Area shown in InCites™ was 1.11% in 2018.
P. P. Wang, X. Y. Zhang, T. T. Fu, S. Li, B. Li, W. W. Xue*, X. J. Yao, Y. Z. Chen, F. Zhu*. Differentiating physicochemical properties between addictive and nonaddictive ADHD drugs revealed by molecular dynamics simulation studies. ACS Chem Neurosci (impact factor of the publication year: 4.348, 化学二区 TOP 期刊). 8(6): 1416-1428 (2017).
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 1.48% in 2021.
- The Percentile in Subject Area shown in InCites™ was 1.80% in 2020.
- The Percentile in Subject Area shown in InCites™ was 1.32% in 2019.
F. Y. Yang, G. X. Zheng, T. T. Fu, X. F. Li, G. Tu, Y. H. Li, X. J. Yao, W. W. Xue*, F. Zhu*. Prediction of binding mode and resistance profile for dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase associated ribonuclease H. Phys Chem Chem Phys (impact factor of the publication year: 4.123, 化学二区 TOP 期刊). 20(37): 23873-23884 (2018).
Back Cover Article:
F. Zhu, L. Y. Han, C. J. Zheng, B. Xie, M. T. Tammi, S. Y. Yang, Y. Q. Wei, Y. Z. Chen*. What are next generation innovative therapeutic targets? Clues from genetic, structural, physicochemical and system profile of successful targets. J Pharmacol Exp Ther (impact factor of the publication year: 3.867, 医学二区 TOP 期刊). 330(1): 304-315 (2009).
Successful Validation of the Constructed Model:
- Pasireotide targeting Somatostatin receptor 1 was approved by FDA in 2011.
- Fingolimod targeting S1P receptor was approved by FDA in 2010.
- Ecallantide targeting Plasma Kallikrein was approved by FDA in 2009.
- Cinryze targeting C1 esterase was approved by FDA in 2009.
- Icatibant targeting BK-2 receptor was approved by FDA in 2008.
- Plerixafor targeting CXCR4 was approved by FDA in 2008.
Q. X. Yang, Y. X. Wang, F. C. Li, S. Zhang, Y. C. Luo, Y. Li, J. Tang, B. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. Identification of the gene signature reflecting schizophrenia's etiology by constructing artificial intelligence-based method of enhanced reproducibility. CNS Neurosci Ther (impact factor of the publication year: 3.394, 医学二区期刊). 25(9): 1054-1063 (2019).
Cover Article:
Z. J. Han, W. W. Xue, L. Tao, F. Zhu*. Identification of novel immune-relevant drug target genes for alzheimer's disease by combining ontology inference with network analysis. CNS Neurosci Ther (impact factor of the publication year: 3.495, 医学二区期刊). 24(12): 1253-1263 (2018).
Honors and Awards:
- Wiley Top Cited Paper Award (2020).
Cover Article:
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