Dr. Feng ZHU

Professor, Doctoral advisor, H-index & My Citations (Google Scholar)

Member of Computational Chemistry Professional Committee of CCS and Task Force on Bioinformatics Professional Committee of CCF; Vice President of Chongqing Bioinformatics Society

zhufeng@zju.edu.cn (primary), prof.zhufeng@gmail.com; +86-571-88208444

Medicinal Chemistry, Drug Design, Target Discovery, Bioinformatics and System Biology

Based on the artificial intelligence and OMIC (proteomics and metabolomics) technologies, we conduct systematical exploration on the druggability and system profile of therapeutic drug targets, develop novel methods and online tools for target discovery, and further study the mechanism underlying the interaction between drugs and their corresponding targets.

Project on going

2019.01 - (PI): National Natural Science Foundation of China - The General Program (81872798)

2018.09 - (PP): National Key Research and Development Program of China (SQ2018YFC090124)

2018.01 - (PI): Zhejiang University Youth Research Innovation Grant (ZJU2018PHA06)

2017.07 - (PI): Zhejiang University "100-Plan Professor" Grant (ZJU2017070)

2016.08 - (PI): National Key Research and Development Program of China (2016YFC0902200)

2015.12 - (PI): Chongqing Special Funds for (Chemical) Drug Discovery (cstc2015zdcy-ztzx120003)

Project finished

2014.06 - (PI): Fundamental Research Funds for the Central Universities (CDJZR14 46 88 01, evaluated as "Excellent")

2013.01 - (PI): Fundamental Research Funds for the Central Universities (CQDXWL-2012-Z003, evaluated as "Excellent")

2013.01 - (PI): National Natural Science Foundation of China - The Youth Program (81202459)

2012.09 - (PI): Chongqing Natural Science Foundation (cstc2012jjA10116)

2012.08 - (PP): Tianjin Key Technology Support Program (tjkjzc2013zd01)

2012.07 - (PI): Youth 100 Talents Program of Chongqing University (0903005203176, evaluated as "Excellent")

PI: Principal Investigator; PP: Project Participant.

1. Y. H. Li, C. Y. Yu, X. X. Li, P. Zhang, J. Tang, Q. X. Yang, T. T. Fu, X. Y. Zhang, X. J. Cui, G. Tu, Y. Zhang, S. Li, F. Y. Yang, Q. Sun, C. Qin, X. Zeng, Z. Chen, Y. Z. Chen*, F. Zhu*. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. Nucleic Acids Res (impact factor of the publication year: 11.561, 生物一区 TOP 期刊). 46(D1): 1121-1127 (2018).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.36% in 2018.

Highlights by Experts in Subject Area:

• Introduced by OMICTOOLS as "useful for facilitating patient focused research, discovery and clinical investigations of the targeted therapeutics".

2. F. Zhu*, X. X. Li, S. Y. Yang, Y. Z. Chen*. The clinical success of drug targets prospectively predicted by the in-silico study. Trends Pharmacol Sci (impact factor of the publication year: 12.797, 医学一区 TOP 期刊). 39(3): 229-231 (2018).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.21% in 2018.

3. B. Li, J. Tang, Q. X. Yang, S. Li, X. J. Cui, Y. H. Li, Y. Z. Chen, W. W. Xue, X. F. Li, F. Zhu*. NOREVA: normalization and evaluation of MS-based metabolomics data. Nucleic Acids Res (impact factor of the publication year: 10.162, 生物一区 TOP 期刊). 45(W1): 162-170 (2017).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 2.98% in 2018.

Highlights by Experts in Subject Area:

• Introduced by OMICTOOLS as "provided valuable guidance to the selection of suitable algorithm in metabolomics".
• Discussed in StackExchange as "works fine" and "corrections for batches without QC options".

4. H. Yang, C. Qin, Y. H. Li, L. Tao, J. Zhou, C. Y. Yu, F. Xu, Z. Chen, F. Zhu*, Y. Z. Chen*. Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information. Nucleic Acids Res (impact factor of the publication year: 9.202, 生物一区 TOP 期刊). 44(D1): 1069-1074 (2016).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.71% in 2018.
• The Percentile in Subject Area shown in InCites™ was 0.87% in 2017.

5. L. Tao, F. Zhu, C. Qin, C. Zhang, F. Xu, C. Y. Tan, Y. Y. Jiang*, Y. Z. Chen*. The nature's contribution to today's pharmacopeia. Nat Biotechnol (impact factor of the publication year: 32.438, 工程一区 TOP 期刊). 32(10): 979-980 (2014).
6. F. Zhu, Z. Shi, C. Qin, L. Tao, X. Liu, F. Xu, L. Zhang, Y. Song, X. H. Liu, J. X. Zhang, B. C. Han, P. Zhang, Y. Z. Chen*. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (impact factor of the publication year: 8.026, 生物一区 TOP 期刊). 40(D1): 1128-1136 (2012).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 0.62% in 2018.
• The Percentile in Subject Area shown in InCites™ was 0.31% in 2017.

Highlights by Experts in Subject Area:

• "FACULTYof1000" as "the top 2% of published articles in biology and medicine" and "a most useful resource for scientists and companies working on drug discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations".
• Prof. Chris Southan in his blog as "Therapeutic Target Database in PubChem".

7. F. Zhu, C. Qin, L. Tao, X. Liu, Z. Shi, X. H. Ma, J. Jia, Y. Tan, C. Cui, J. S. Lin, C. Y. Tan, Y. Y. Jiang*, Y. Z. Chen*. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A (impact factor of the publication year: 9.432, 综合性一区 TOP 期刊). 108(31): 12943-12948 (2011).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 1.16% in 2018.
• The Percentile in Subject Area shown in InCites™ was 1.91% in 2017.

Highlights by Experts in Subject Area:

• "It Takes 30" of Department of System Biology @ Harvard Medical School as "Drugs run in families".
• International Cooperative Biodiversity Groups as "Highlighted literature citations for Aug 2011".

Media Coverage & News Report:

• NEWS MEDICAL. Sep 8th, 2011.
• Medical News Today (MNT). Sep 7th, 2011.
• mediLexicon.com. Sep 7th, 2011.
• BrightSurf.com. Sep 7th, 2011.
• SCIENCE CODEX. Sep 6th, 2011.
• Sciencenewsline biology. Sep 6th, 2011.
• MedicalXpress. Sep 6th, 2011.
• FirstScience News. Sep 6th, 2011.
• Labspaces.net. Sep 6th, 2011.
• EurekAlert. Sep 6th, 2011.
• eBioNews. Sep 1st, 2011.
• ScienceDaily. Aug 31st, 2011.
• HealthCanal.com. Aug 31st, 2011.
• News Ecology. Aug 31st, 2011.

8. H. B. Rao^#, F. Zhu^#, G. B. Yang, Z. R. Li*, Y. Z. Chen. Update of PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequences. Nucleic Acids Res (impact factor of the publication year: 7.836, 生物一区 TOP 期刊). 39(W1): 385-390 (2011).
9. F. Zhu, B. C. Han, P. Kumar, X. H. Liu, X. H. Ma, X. N. Wei, L. Huang, Y. F. Guo, L. Y. Han, C. J. Zheng, Y. Z. Chen*. Update of TTD: therapeutic target database. Nucleic Acids Res (impact factor of the publication year: 7.479, 生物一区 TOP 期刊). 38(D1): 787-791 (2010).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 2.95% in 2017.

10. J. Jia, F. Zhu, X. H. Ma, Z. W. Cao, Y. X. Li, Y. Z. Chen*. Mechanisms of drug combinations: interaction and network perspectives. Nat Rev Drug Discov (impact factor of the publication year: 23.308, 医学一区 TOP 期刊). 8(2): 111-128 (2009).

ESI Highly Cited Paper:

• The Percentile in Subject Area shown in InCites™ was 1.13% in 2018.
• The Percentile in Subject Area shown in InCites™ was 1.39% in 2017.

Vice-chairman of the Symposium 24 Session-4 for The 31st Academic Annual Conference of the Chinese Chemical Society. Zhejiang University, Hangzhou, P. R. China (2018)

Chairman of the Symposium IV Session -7 (metabonomics) for Asian Federation for Pharmaceutical Sciences Conference 2017. Xiamen University, Xiamen, P. R. China (2017)

Member of the Academic Committee for The 14th National Symposium of Computer & Computational Chemistry. Nanjing University, Nanjing, P. R. China (2017)

Member of the Academic Committee for The Second CCF Bioinformatics Conference (CBC-2017). Central South University, Changsha, P. R. China (2017)

Chairman of the sub-conference 103 (multi-target and protein-protein interaction) for BIT’s 6th Annual International Congress of Medichem-2016 (ICM-2016) . China Pharmaceutical University, Nanjing, P. R. China. (2016)

Vice-chairman of the 6th theme (study on drug transporter and PK/PD) for BIT’s 6th Annual International Congress of Medichem-2016 (ICM-2016) . China Pharmaceutical University, Nanjing, P. R. China. (2016)

Chair of the Organizing Committee and the Member of the Academic Committee for The 2nd Symposium on Bioinformatics and Drug Design. Chongqing University, Chongqing, P. R. China. (2016)

Member of the Academic Committee for The 13th National Symposium of Computer & Computational Chemistry. Sun Yat-sen University, Guangzhou, P. R. China. (2015)

Member of the Organizing Committee for International Symposium on Natural Product Synthesis and Innovative Process Methods for Drug Manufacture. Chongqing University, Chongqing, P. R. China. (2012)

Keynote Speaker
• 11th China-Japan Symposium on Molecular Drug Design and Development. Zhejiang University and Peking Union Medical College, Chinese Academy of Medical Sciences, Shaoxing, China (2018)
• 2017 Symposium on Pharmaceutical Chemistry of the Yangtze River Delta Metropolitan Region. Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, China (2017)

Invited Speaker
• 14th Symposium of the CPA Youth Pharmacologist. Chinese Pharmaceutical Association, Hangzhou, China (2018)
• 2nd Worldwide Computational Biology and Molecular Simulation Conference. Sun Yat-sen University, Guangzhou, China (2018)
• 31st Academic Annual Conference of the Chinese Chemical Society. Zhejiang University, Hangzhou, China (2018)
• Asian Federation for Pharmaceutical Sciences Conference 2017. Xiamen University, Xiamen, China (2017)
• 14th National Symposium of Computer & Computational Chemistry. Nanjing University, Nanjing, China (2017)
• 5th Academic Forum for Postgraduates. Sichuan University, Chengdu, China (2017)
• 2nd Conference on Innovative Drug Research and Application. Nanjing Biotech and Pharmaceutical Valley, Nanjing, China (2017)
• Bioinformatics and Intelligent Information Processing Conference. Shanghai Jiao Tong University, Shanghai, China (2017)
• Fifth Young Scholars Forum for Interdisciplinary Researches. Chinese Academy of Sciences, Beijing, China (2017)
• 2017 (the second) Conference on Precision and Future Medicine. Zhejiang University, Hangzhou, China (2017)
• China Society of Biotechnology Young Scientists Forum II . South China University of Technology, Guangzhou, China (2017)
• 2016 Symposium of Guanghua Young Distinguished Scholars . Fudan University, Shanghai, China (2016)
• BIT’s 6th Annual International Congress of Medichem-2016. China Pharmaceutical University, Nanjing, China (2016)
• 1st International Symposium on Targeted Therapeutics. Chongqing University of Arts and Sciences, Chongqing, China (2016)
• 4th International Conference on Molecular Simulation. Shanghai Jiao Tong University, Shanghai, China (2016)
• 7th National Conference on Bioinformatics. University of Electronic Science and Technology of China, Chengdu, China (2016)
• 2016 Conference on Precision Medicine. Xian Jiaotong University, Xian, China (2016)
• 12th Sino-US Chemistry Professors Conference. Sun Yat-sen University, Guangzhou, China (2016)
• 2016 Symposium of International Young Distinguished Scholars. Tongji University, Shanghai, China (2016)
• 2nd Symposium on Bioinformatics and Drug Design. Chongqing University, Chongqing, China (2016)
• 2016 Conference on Bioinformatics and Intelligent Information Processing. Jilin University, Jilin, China (2016)
• 30th Academic Annual Conference of the Chinese Chemical Society. Dalian University of Technology, Dalian, China (2016)
• 2016 Academic Salon of Shanghai Society for Bioinformatics. Fudan University, Shanghai, China (2016)
• 2016 Symposium of Big Data and Precision Biomedical Informatics. Shanghai Jiao Tong University, Shanghai, China (2016)
• 13th National Symposium of Computer & Computational Chemistry. Sun Yat-sen University, Guangzhou, China (2015)
• 6th International Conference of Molecular Simulation. China Pharmaceutical University, Nanjing, China (2012)