Zhejiang U | College of Pharmaceutical Sciences | 中文版
     
     
Feng ZHU - IDRC - Chongqing University
ABOUT THE PRINCIPAL INVESTIGATOR

Dr. Feng ZHU

Tenured Full Professor, Zhejiang University, Hangzhou

Associate Editor, Journal of Chemical Information and Modeling, American Chemical Society

Web of Science h-index: 44 ;   Scopus h-index: 46 ;   Google Scholar h-index: 48

zhufeng@zju.edu.cn (primary), prof.zhufeng@gmail.com; +86-571-88208444
PERSONAL DETAILS
Research Interests: Medicinal Chemistry, Drug Design, Target Discovery, Bioinformatics and System Biology

Based on the artificial intelligence and OMIC (proteomics and metabolomics) technologies, we conduct systematical exploration on the druggability and system profile of therapeutic drug targets, develop novel methods and online tools for target discovery, and further study the mechanism underlying the interaction between drugs and their corresponding targets.
  Academic Appointments and Educational Qualifications
  Honors and Awards
    Representative Honors & Awards

  • Leading Talent of the National High-Level Talent Special Support Plan of China (2020)

  • Honorable Professor of the Youth International Recruitment Program of China (2014)

  • Leading Talent of the Science & Technology Nova Program of Chinese MOST (2019)

  • Corresponding Author of the Publications of Top-100 World-wide Impact of Chinese MOST (2021)

  • Laureate of the Fund for Distinguished Young Scholars of Zhejiang Province (2021)

  • Honorable Professor of the High-level Talent Support Plan of Zhejiang Province (2018)

  • Laureate of the 100,000 Top-scientists of Global Author ID Database (2021,  2022)

  • Laureate of the 100,000 Top-scientists of Stanford University Science-wide Author Database (2020,  2021,  2022)

  • Laureate of the Best Biology and Biochemistry Scientists of Global Academic Sites Research.com (2022)

  • Laureate of the Leading Scholar in Social Practice of JiuSan Society (2021)

  • Laureate of the Top Cited Paper Award of Wiley Publication Group (2020)

  • Supervisor of the Outstanding Doctor Postgraduate of Zhejiang Province (2021)

  • Supervisor of the Outstanding Master Postgraduate of Zhejiang Province (2020)

    • Other Honors & Awards

  • Key Innovative Team Member of the Science & Technology Nova Program of Chinese MOST (2019)

  • Laureate of the First Class Science & Technology Award of Chongqing Province (Ranked 4th, 2019)

  • Supervisor of the Third Class Challenge Cup Award of Zhejiang Province (2021)

  • Laureate of the First Class Shihuayu Teaching Scholarship of Zhejiang University (2021)

  • Supervisor of the Jiangzhi Biomedical Award of Zhejiang University (2020)

  • Supervisor of the Second Class Challenge Cup Award of Zhejiang University (2021)

  • Laureate of the Third Class Tanglixin Teaching Scholarship of Chongqing University (2014)

  • Laureate of the Top-10 Annual Scientific Advances of College of Pharmaceutical Sciences in Zhejiang University (2022)

  • Laureate of the Annual Outstanding Professor of College of Pharmaceutical Sciences in Zhejiang University (2020)

  • Laureate of the Annual Outstanding Professor of College of Pharmaceutical Sciences in Zhejiang University (2019)
  Educational Reform Projects (PI: Principal Investigator; PP: Project Participant)
  • 2022.10 - (PI, 省部级): IECC Foundation of the Ministry of Education of China (2022-AliC-4-32)

  • 2021.12 - (PI, 省部级): Textbook Construction in 13th Five-Year Plan of Zhejiang Province (2021-135-33)

  • 2021.01 - (PI, 学校级): Postgraduate Education Reform Foundation of China (zyjyjx-grazju-49)

  • 2020.06 - (PI, 学校级): Undergraduate Education Reform Foundation of China (068-484607)

  • 2020.09 - (PI, 学校级): Postgraduate Education Reform Foundation of Zhejiang University (1913039)
  Research Grants (PI: Principal Investigator; PP: Project Participant)
    Project(s) on Going

  • 2020.10 - (PI, 国家级): National Leading Talent Special Support Plan of China (CWR-L-ZJU2020-ZF)

  • 2020.01 - (PI, 国家级): National Natural Science Foundation Collaboration Program of China (U1909208)

  • 2019.01 - (PI, 国家级): National Natural Science Foundation General Program of China (81872798)

  • 2021.01 - (PI, 省部级): Fund for Distinguished Young Scholars of Zhejiang Province (LR21H300001)

  • 2021.05 - (PI, 省部级): Research Fund for Injury Prevention of Zhejiang Province (181201*194232101)

  • 2020.01 - (PI, 省部级): Key Research and Development Program of Zhejiang Province (2020C03010)

  • 2021.02 - (PI, 学校级): Fund for Future Digital Healthcare of Alibaba-ZJU Collaboration (ALIZJU202101)

    • Project(s) Completed

  • 2014.06 - (PI, 国家级): Youth International Recruitment Program of China (IRPC-Y-CQU2014-ZF)

  • 2016.08 - (PI, 国家级): National Key Research and Development Program of China (2016YFC0902200)

  • 2018.09 - (PI, 国家级): National Key Research and Development Program of China (2018YFC0910500)

  • 2013.01 - (PI, 国家级): National Natural Science Foundation Youth Program of China (81202459)

  • 2015.12 - (PI, 省部级): Special Fund for Chemical Drug Discovery of Chongqing Province (cstc2015zdcy-ztzx120003)

  • 2012.09 - (PI, 省部级): Natural Science Foundation General Program of Chongqing Province (cstc2012jjA10116)

  • 2017.07 - (PI, 学校级): Hundreds-Talents Program of Zhejiang University (ZJU2017070, evaluated as "Excellent")

  • 2012.07 - (PI, 学校级): Hundreds-Talents Program of Chongqing University (0903005203176, evaluated as "Excellent")

  • 2014.06 - (PI, 学校级): Major Fundation for Chongqing University (CDJZR14 46 88 01, evaluated as "Excellent")

  • 2013.01 - (PI, 学校级): Key Fundation for Chongqing University (CQDXWL-2012-Z003, evaluated as "Excellent")

  • 2018.01 - (PI, 学校级): Youth Research Innovation Grant of Zhejiang University (2018QNA7023)
  Selected Publications (*corresponding author; highlighted graphic abstract; PDF version of paper)
  1. J. B. Fu, Y. Zhang, Y. X. Wang, H. N. Zhang, J. Liu, J. Tang, Q. X. Yang, H. C. Sun, W. Q. Qiu, Y. H. Ma, Z. R. Li, M. Y. Zheng, F. Zhu*. Optimization of metabolomic data processing using NOREVA. Nature Protocols (impact factor of the publication year: 17.021, 生物一区 TOP 期刊). 17(1): 129-151 (2022). PMID: 34952956.
    2. Featured Article: Media Coverage & News Report:

  2. Y. X. Wang, S. Zhang, F. C. Li, Y. Zhou, Y. Zhang, Z. W. Wang, R. Y. Zhang, J. Zhu, Y. X. Ren, Y. Tan, C. Qin, Y. H. Li, X. X. Li, Y. Z. Chen*, F. Zhu*. Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. Nucleic Acids Research (impact factor of the publication year: 16.971, 生物一区 TOP 期刊). 48(D1): 1031-1041 (2020). PMID: 31691823.
    3. Publication of World-wide Reputation: ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.13% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.15% in 2021.
    Media Coverage & News Report:

  3. X. N. Sun, Y. T. Zhang, H. Y. Li, Y. Zhou, S. Y. Shi, Z. Chen, X. He, H. Y. Zhang, F. C. Li, J. Y. Yin, M. J. Mou, Y. Z. Wang, Y. Q. Qiu, F. Zhu*. DRESIS: a comprehensive database for drug resistance information. Nucleic Acids Research (impact factor of the publication year: 19.160, 生物一区 TOP 期刊). accepted: NAR-02475 (2023).

  4. Q. X. Yang, Y. X. Wang, Y. Zhang, F. C. Li, W. Q. Xia, Y. Zhou, Y. Q. Qiu, H. L. Li, F. Zhu*. NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data. Nucleic Acids Research (impact factor of the publication year: 16.971, 生物一区 TOP 期刊). 48(W1): 436-448 (2020). PMID: 32324219.
    5. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 1.60% in 2022.
    Media Coverage & News Report:

  5. F. C. Li, J. Y. Yin, M. K. Lu, M. J. Mou, Z. R. Li, Z. Y. Zeng, Y. Tan, S. S. Wang, X. Y. Chu, H. B. Dai, T. J. Hou, S. Zeng*, Y. Z. Chen*, F. Zhu*. DrugMAP: molecular atlas and pharma-information of all drugs. Nucleic Acids Research (impact factor of the publication year: 19.160, 生物一区 TOP 期刊). doi: 10.1093/nar/gkac813 (2023). PMID: 36243961.
    6. Cover Article: Media Coverage & News Report:

  6. T. T. Fu, F. C. Li, Y. Zhang, J. Y. Yin, W. Q. Qiu, X. D. Li, X. G. Liu, W. W. Xin, C. Z. Wang, L. S. Yu, J. Q. Gao, Q. C. Zheng*, S. Zeng*, F. Zhu*. VARIDT 2.0: structural variability of drug transporter. Nucleic Acids Research (impact factor of the publication year: 19.160, 生物一区 TOP 期刊). 50(D1): 1417-1431 (2022). PMID: 34747471.
    7. Media Coverage & News Report:

  7. J. Y. Yin, F. C. Li, Y. Zhou, M. J. Mou, Y. J. Lu, K. L. Chen, J. Xue, Y. C. Luo, J. B. Fu, X. He, J. Q. Gao, S. Zeng*, L. S. Yu*, F. Zhu*. INTEDE: interactome of drug-metabolizing enzymes. Nucleic Acids Research (impact factor of the publication year: 19.160, 生物一区 TOP 期刊). 49(D1): 1233-1243 (2021). PMID: 33045737.
    8. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 1.12% in 2022.
    Media Coverage & News Report:

  8. B. Li, J. Tang, Q. X. Yang, S. Li, X. J. Cui, Y. H. Li, Y. Z. Chen, W. W. Xue, X. F. Li, F. Zhu*. NOREVA: normalization and evaluation of MS-based metabolomics data. Nucleic Acids Research (impact factor of the publication year: 10.162, 生物一区 TOP 期刊). 45(W1): 162-170 (2017). PMID: 28525573.
    9. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.77% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.71% in 2021.
    • The Percentile in Subject Area shown in InCites™ was 0.75% in 2020.
    • The Percentile in Subject Area shown in InCites™ was 1.27% in 2019.
    • The Percentile in Subject Area shown in InCites™ was 2.98% in 2018.
    Highlights by Experts in Subject Area:
    • Introduced by OMICTOOLS as "provided valuable guidance to the selection of suitable algorithm in metabolomics".
    • Discussed in StackExchange as "works fine" and "corrections for batches without QC options".

  9. Y. H. Li, C. Y. Yu, X. X. Li, P. Zhang, J. Tang, Q. X. Yang, T. T. Fu, X. Y. Zhang, X. J. Cui, G. Tu, Y. Zhang, S. Li, F. Y. Yang, Q. Sun, C. Qin, X. Zeng, Z. Chen, Y. Z. Chen*, F. Zhu*. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. Nucleic Acids Research (impact factor of the publication year: 11.561, 生物一区 TOP 期刊). 46(D1): 1121-1127 (2018). PMID: 29140520.
    10. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.21% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.15% in 2021.
    • The Percentile in Subject Area shown in InCites™ was 0.14% in 2020.
    • The Percentile in Subject Area shown in InCites™ was 0.16% in 2019.
    Highlights by Experts in Subject Area:
    • Introduced by OMICTOOLS as "useful for facilitating patient focused research, discovery and clinical investigations of the targeted therapeutics".

  10. J. Y. Yin, W. Sun, F. C. Li, J. J. Hong, X. X. Li, Y. Zhou, Y. J. Lu, M. Z. Liu, X. Zhang, N. Chen, X. P. Jin, J. Xue, S. Zeng*, L. S. Yu*, F. Zhu*. VARIDT 1.0: variability of drug transporter database. Nucleic Acids Research (impact factor of the publication year: 16.971, 生物一区 TOP 期刊). 48(D1): 1042-1050 (2020). PMID: 31495872.
    11. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.96% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.33% in 2021.
    Media Coverage & News Report:

  11. K. Amahong, W. Zhang, Y. Zhou, S. Zhang, J. Y. Yin, F. C. Li, H. Q. Xu, T. C, Yan, Z. X. Yue, Y. H. Liu, T. J. Hou, Y. Q. Qi, L. Tao*, L. Y. Han*, F. Zhu*. CovInter: interaction data between coronavirus RNAs and host proteins. Nucleic Acids Research (impact factor of the publication year: 19.160, 生物一区 TOP 期刊). doi: 10.1093/nar/gkac834 (2023). PMID: 36200814.
    12. Media Coverage & News Report:

  12. X. N. Wang, F. C. Li, W. Q. Qiu, B. B. Xu, Y. L. Li, X. C. Lian, H. Y. Yu, Z. Zhang, J. X. Wang, Z. R. Li, W. W. Xue*, F. Zhu*. SYNBIP: synthetic binding proteins for research, diagnosis and therapy. Nucleic Acids Research (impact factor of the publication year: 19.160, 生物一区 TOP 期刊). 50(D1): 560-570 (2022). PMID: 34664670.
    13. Media Coverage & News Report:

  13. S. P. Liu, L. Chen, Y. T. Zhang, Y. Zhou, Y. He, Z. Chen, S. S. Qi, J. Y. Zhu, X. D. Chen, H. Zhang, Y. C. Luo, Y. Q. Qiu, L. Tao*, F. Zhu*. M6AREG: m6A-centered regulation of disease development and drug response Nucleic Acids Research (impact factor of the publication year: 19.160, 生物一区 TOP 期刊). doi: 10.1093/nar/gkac801 (2023). PMID: 36134713

  14. J. Tang, X. L. Wu, M. J. Mou, C. Wang, L. D. Wang, F. C. Li, M. Y. Guo, J. Y. Yin, W. Q. Xie, X. N. Wang, Y. X. Wang, Y. B. Ding*, W. W. Xue*, F. Zhu*. GIMICA: host genetic and immune factors shaping human microbiota. Nucleic Acids Research (impact factor of the publication year: 19.160, 生物一区 TOP 期刊). 49(D1): 715-722 (2021). PMID: 33045729.
    15. Media Coverage & News Report:

  15. F. Zhu, Z. Shi, C. Qin, L. Tao, X. Liu, F. Xu, L. Zhang, Y. Song, X. H. Liu, J. X. Zhang, B. C. Han, P. Zhang, Y. Z. Chen*. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Research (impact factor of the publication year: 8.026, 生物一区 TOP 期刊). 40(D1): 1128-1136 (2012). PMID: 21948793.
    16. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.77% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.69% in 2021.
    • The Percentile in Subject Area shown in InCites™ was 0.66% in 2020.
    • The Percentile in Subject Area shown in InCites™ was 0.60% in 2019.
    • The Percentile in Subject Area shown in InCites™ was 0.62% in 2018.
    • The Percentile in Subject Area shown in InCites™ was 0.31% in 2017.

    Highlights by Experts in Subject Area:

    • "FACULTYof1000" as "the top 2% of published articles in biology and medicine" and "a most useful resource for scientists and companies working on drug discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations".
    • Prof. Chris Southan in his blog as "Therapeutic Target Database in PubChem".

  16. F. Zhu, B. C. Han, P. Kumar, X. H. Liu, X. H. Ma, X. N. Wei, L. Huang, Y. F. Guo, L. Y. Han, C. J. Zheng, Y. Z. Chen*. Update of TTD: therapeutic target database. Nucleic Acids Research (impact factor of the publication year: 7.479, 生物一区 TOP 期刊). 38(D1): 787-791 (2010). PMID: 19933260.
    17. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 2.95% in 2017.

  17. F. Zhu, C. Qin, L. Tao, X. Liu, Z. Shi, X. H. Ma, J. Jia, Y. Tan, C. Cui, J. S. Lin, C. Y. Tan, Y. Y. Jiang*, Y. Z. Chen*. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proceedings of the National Academy of Sciences of the United States of America (impact factor of the publication year: 9.432, 综合性一区 TOP 期刊). 108(31): 12943-12948 (2011). PMID: 21768386.
    18. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.95% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.98% in 2021.
    • The Percentile in Subject Area shown in InCites™ was 0.93% in 2020.
    • The Percentile in Subject Area shown in InCites™ was 0.94% in 2019.
    • The Percentile in Subject Area shown in InCites™ was 1.16% in 2018.
    • The Percentile in Subject Area shown in InCites™ was 1.91% in 2017.
    Highlights by Experts in Subject Area: Media Coverage & News Report:

  18. Y. H. Li, X. X. Li, J. J. Hong, Y. X. Wang, J. B. Fu, H. Yang, C. Y. Yu, F. C. Li, J. Hu, W. W. Xue, Y. Y. Jiang, Y. Z. Chen*, F. Zhu*. Clinical trials, progression-speed differentiating features, and swiftness rule of the innovative targets of first-in-class drugs. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 21(2): 649-662 (2020). PMID: 30689717.
    19. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.49% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.09% in 2021.

  19. J. Tang, J. B. Fu, Y. X. Wang, B. Li, Y. H. Li, Q. X. Yang, X. J. Cui, J. J. Hong, X. F. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. ANPELA: analysis and performance-assessment of the label-free quantification workflow for metaproteomic studies. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 21(2): 621-636 (2020). PMID: 30649171.
    20. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.20% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.05% in 2021.

  20. Q. X. Yang, B. Li, J. Tang, X. J. Cui, Y. X. Wang, X. F. Li, J. Hu, Y. Z. Chen, W. W. Xue, Y. Lou, Y. Q. Qiu*, F. Zhu*. Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 21(3): 1058-1068 (2020). PMID: 31157371.
    21. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.56% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.19% in 2021.

  21. J. J. Hong, Y. C. Luo, M. J. Mou, J. B. Fu, Y. Zhang, W. W. Xue, T. Xie, L. Tao*, Y. Lou*, F. Zhu*. Convolutional neural network-based annotation of bacterial type IV secretion system effectors with enhanced accuracy and reduced false discovery. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 21(5): 1825-1836 (2020). PMID: 31860715.
    22. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 1.18% in 2022.

  22. Z. J. Han, W. W. Xue, L. Tao, Y. Lou, Y. Q. Qiu*, F. Zhu*. Genome-wide identification and analysis of the eQTL lncRNAs in multiple sclerosis based on RNA-seq data. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 21(3): 1023-1037 (2020). PMID: 31323688.
    23. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 2.22% in 2022.

  23. J. J. Hong, Y. C. Luo, Y. Zhang, J. B. Ying, W. W. Xue, T. Xie, L. Tao*, F. Zhu*. Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 21(4): 1437-1447 (2020). PMID: 31504150.
    24. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.94% in 2022.

  24. Q. X. Yang, J. J. Hong, Y. Li, W. W. Xue, S. Li*, H. Yang*, F. Zhu*. A novel bioinformatics approach to identify the consistently well-performing normalization strategy for current metabolomic studies. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 21(6): 2142-2152 (2020). PMID: 31776543.
    25. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 2.69% in 2022.

  25. F. C. Li, Y. Zhou, Y. Zhang, J. Y. Yin, Y. Q. Qiu, J. Q. Gao, F. Zhu*. POSREG: proteomic signature discovered by simultaneously optimizing its reproducibility and generalizability. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). 23(2): bbac040 (2022). PMID: 35183059.

  26. F. C. Li, J. Y. Yin, M. K. Lu, Q. X. Yang, Z. Y. Zeng, B. Zhang, Z. R. Li, Y. Q. Qiu, H. B. Dai, Y. Z. Chen*, F. Zhu*. ConSIG: consistent discovery of molecular signature from OMIC data. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). 23(4): bbac253 (2022). PMID: 35758241. 

  27. S. Zhang, K. Amahong, C. Y. Zhang, F. C. Li, J. Q. Gao, Y. Q. Qiu*, F. Zhu*. RNA-RNA interactions between SARS-CoV-2 and host benefit viral development and evolution during COVID-19 infection. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). 23(1): bbab397 (2022). PMID: 34585235.

  28. S. Zhang, Y. Zhou, Y. N. Wang, Z. W. Wang, Q. T. Xiao, Y. Zhang, Y. Lou, Y. Q. Qiu*, F. Zhu*. The mechanistic, diagnostic and therapeutic novel nucleic acids for hepatocellular carcinoma emerging in past score years. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). 22(2): 1860-1883 (2021). PMID: 32249290.

  29. J. B. Fu, Y. Zhang, J. Liu, X. C. Lian, J. Tang, F. Zhu*. Pharmacometabonomics: data processing and statistical analysis. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). 22(5): bbab138 (2021). PMID: 33866355.

  30. J. Tang, M. J. Mou, Y. X. Wang, Y. C. Luo, F. Zhu*. MetaFS: performance assessment of biomarker discovery in metaproteomics. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). 22(3): bbaa105 (2021). PMID: 32510556.

  31. Y. C. Luo, P. P. Wang, M. J. Mou, H. Q. Zheng, J. J. Hong, L. Tao, F. Zhu*. A novel strategy for designing the magic shotguns for distantly related target pairs. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). accepted: BIB-22-1897 (2022). PMID: XXXXXXXX.

  32. J. B. Fu, Q. X. Yang, Y. C. Luo, S. Zhang, J. Tang, Y. Zhang, H. N. Zhang, H. X. Xu, F. Zhu*. Label-free proteome quantification and evaluation. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). doi: 10.1093/bib/bbac477 (2022). PMID: 36403090.

  33. Q. X. Yang, B. Li, P. P. Wang, J. C. Xie, Y. H. Feng, Z. Q. Liu, F. Zhu*. LargeMetabo: an out-of-the-box tool for processing and analyzing large-scale metabolomic data. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). doi: 10.1093/bib/bbac455 (2022). PMID: 36274234.

  34. H. Y. Zhang, Y. X. Wang, Z. Q. Pan, X. N. Sun, M. J. Mou, B. Zhang, Z. R. Li, H. L. Li*, F. Zhu*. ncRNAInter: a novel strategy based on graph neural network to discover interactions between lncRNA and miRNA. Briefings in Bioinformatics (impact factor of the publication year: 13.994, 生物一区 TOP 期刊). doi: 10.1093/bib/bbac411 (2022). PMID: 36198065.

  35. J. Tang, Y. X. Wang, J. B. Fu, Y. Zhou, Y. C. Luo, Y. Zhang, B. Li, Q. X. Yang, W. W. Xue, Y. Lou, Y. Q. Qiu*, F. Zhu*. A critical assessment of the feature selection methods used for biomarker discovery in current metaproteomic studies. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 21(4): 1378-1390 (2020). PMID: 31197323.

  36. S. Zhang, F. Zhu*. Comment on microRNA mimics or inhibitors as antiviral therapeutic approaches against COVID-19. Drugs (impact factor of the publication year: 11.431, 医学二区 TOP 期刊). 81(14): 1691-1692 (2021). PMID: 34453690.

  37. Y. X. Wang, F. C. Li, Y, Zhang, Y. Zhou, Y. Tan, Y. Z. Chen*, F. Zhu*. Databases for the targeted COVID-19 therapeutics. British Journal of Pharmacology (impact factor of the publication year: 7.730, 医学二区 TOP 期刊). 177(21): 4999-5001 (2020). PMID: 32845521.

  38. S. Zhang, X. N. Sun, M. J. Mou, K. Amahong, H. C. Sun, W. Zhang, S. Y. Shi, Z. R. Li, J. Q. Gao, F. Zhu*. REGLIV: molecular regulation data of diverse living systems facilitating current multiomics research.  Computers in Biology and Medicine (impact factor of the publication year: 6.698, 工程技术二区期刊). 148: 105825 (2022). PMID: 35872412. .

  39. W. Q. Xia, L. Y. Zheng, J. B. Fang, F. C. Li, Y. Zhou, Z. Y. Zeng, B. Zhang, Z. R. Li, H. L. Li*, F. Zhu*. PFmulDL: a novel strategy enabling multi-class and multi-label protein function annotation by integrating diverse deep learning methods. Computers in Biology and Medicine (impact factor of the publication year: 6.698, 工程技术二区期刊). 145: 105465 (2022). PMID: 35366467. 

  40. J. Y. Yin, X. X. Li, F. C. Li, Y. J. Lu, S. Zeng*, F. Zhu*. Identification of the key target profiles underlying the drugs of narrow therapeutic index for treating cancer and cardiovascular disease. Computational and Structural Biotechnology Journal (impact factor of the publication year: 7.271, 生物二区期刊). 19: 2318-2328 (2021). PMID: 33995923.

  41. K. Merz, G. W. Wei, F. Zhu*. Editorial machine learning in bio-cheminformatics. Journal of Chemical Information and Modeling (impact factor of the publication year: 6.162, 化学二区期刊). accepted: ci-2022-01496t (2022). PMID: XXXXXXXX.

  42. M. J. Mou, Z. Q. Pan, M. K. Lu, H. C. Sun, Y. X. Wang, Y. C. Luo, F. Zhu*. Application of machine learning in spatial proteomics. Journal of Chemical Information and Modeling (impact factor of the publication year: 6.162, 化学二区期刊). 62(23): 5875–5895. PMID: 36378082.

  43. J. Tang, Y. X. Wang, Y. C. Luo, J. B. Fu, Y. Zhang, Y. Li, Z. Y. Xiao, Y. Lou, Y. Q. Qiu*, F. Zhu*. Computational advances of tumor marker selection and sample classification in cancer proteomics. Computational and Structural Biotechnology Journal (impact factor of the publication year: 6.018, 生物二区 TOP 期刊). 18: 2012-2025 (2020). PMID: 32802273.

  44. T. T. Fu, G. Tu, M. Ping, G. X. Zheng, F. Y. Yang, J. Y. Yang, Y. Zhang, X. J. Yao, W. W. Xue*, F. Zhu*. Subtype selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors. Acta Pharmacologica Sinica (impact factor of the publication year: 6.150, 医学一区 TOP 期刊). 42(8): 1354-1367 (2021). PMID: 33122823.

  45. J. Tang, J. B. Fu, Y. X. Wang, Y. C. Luo, Q. X. Yang, B. Li, G. Tu, J. J. Hong, X. J. Cui, Y. Z. Chen, L. X. Yao, W. W. Xue, F. Zhu*. Simultaneous improvement in the precision, accuracy and robustness of label-free proteome quantification by optimizing data manipulation chains. Molecular & Cellular Proteomics (impact factor of the publication year: 5.236, 生物二区 TOP 期刊). 18(8): 1683-1699 (2019). PMID: 31097671.
    46. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 1.12% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.81% in 2021.
    • The Percentile in Subject Area shown in InCites™ was 0.57% in 2020.

  46. F. C. Li, Y. Zhou, X. Y. Zhang, J. Tang, Q. X. Yang, Y. Zhang, Y. C. Luo, J. Hu*, W. W. Xue, Y. Q. Qiu, Q. J. He, B. Yang, F. Zhu*. SSizer: determining the sample sufficiency for comparative biological study. Journal of Molecular Biology (impact factor of the publication year: 5.067, 生物二区 TOP 期刊). 432(11): 3411-3421 (2020). PMID: 32044343.

  47. Y. Zhang, J. B. Ying, J. J. Hong, F. C. Li, T. T. Fu, F. Y. Yang, G. X. Zheng, X. J. Yao, Y. Lou, Y. Q. Qiu, W. W. Xue*, F. Zhu*. How does chirality determine the selective inhibition of histone deacetylase 6? A lesson from Trichostatin A enantiomers based on molecular dynamics. ACS Chemical Neuroscience (impact factor of the publication year: 4.211, 化学二区 TOP 期刊). 10(5): 2467-2480 (2019). PMID: 30784262.
    48. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 1.85% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 1.19% in 2021.
    • The Percentile in Subject Area shown in InCites™ was 0.74% in 2020.
    Cover Article:

  48. W. W. Xue, F. Y. Yang, P. P. Wang, G. X. Zheng, Y. Z. Chen, X. J. Yao, F. Zhu*. What contributes to serotonin-norepinephrine reuptake inhibitors' dual-targeting mechanism? The key role of transmembrane domain 6 in human serotonin and norepinephrine transporters revealed by molecular dynamics simulation. ACS Chemical Neuroscience (impact factor of the publication year: 4.211, 化学二区 TOP 期刊). 9(5): 1128-1140 (2018). PMID: 29300091.
    49. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.18% in 2022.
    • The Percentile in Subject Area shown in InCites™ was 0.14% in 2021.
    • The Percentile in Subject Area shown in InCites™ was 0.21% in 2020.
    • The Percentile in Subject Area shown in InCites™ was 0.29% in 2019.

  49. W. W. Xue, T. T. Fu, S. Z. Deng, F. Y. Yang, J. Y. Yang, F. Zhu*. Molecular mechanism for the allosteric inhibition of the human serotonin transporter by antidepressant escitalopram. ACS Chemical Neuroscience (impact factor of the publication year: 5.780, 医学二区期刊). 13(3): 340-351 (2022). PMID: 35041375.
    50. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 0.09% in 2022.

  50. G. Tu, T. T. Fu, F. Y. Yang, J. Y. Yang, Z. Zhang, X. J. Yao, W. W. Xue*, F. Zhu*. Understanding the polypharmacological profiles of triple reuptake inhibitors by molecular simulation. ACS Chemical Neuroscience (impact factor of the publication year: 4.418, 医学二区期刊). 12(11): 2013-2026 (2021). PMID: 33977725.

  51. F. Y. Yang, G. X. Zheng, T. T. Fu, X. F. Li, G. Tu, Y. H. Li, X. J. Yao, W. W. Xue*, F. Zhu*. Prediction of binding mode and resistance profile for dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase associated ribonuclease H. Physical Chemistry Chemical Physics (impact factor of the publication year: 4.123, 化学二区 TOP 期刊). 20(37): 23873-23884 (2018). PMID: 29947629.
    52. Back Cover Article:

  52. Q. X. Yang, B. Li, S. J. Chen, J. Tang, Y. H. Li, Y. Li, S. Zhang, C. Shi, Y. Zhang, M. J. Mou, W. W. Xue*, F. Zhu*. MMEASE: online meta-analysis of metabolomic data by enhanced metabolite annotation, marker selection and enrichment analysis. Journal of Proteomics (impact factor of the publication year: 4.044, 生物二区期刊). 232: 104023 (2021). PMID: 33130111.
    53. ESI Highly Cited Paper:
    • The Percentile in Subject Area shown in InCites™ was 2.51% in 2022.

  53. F. Y. Yang, J. Y. Yang, Z. Zhang, G. Tu, X. J. Yao, W. W. Xue*, F. Zhu*. Recent advances in computer-aided antiviral drug design targeting HIV-1 integrase and reverse transcriptase associated ribonuclease H. Current Medicinal Chemistry (impact factor of the publication year: 4.740, 医学三区期刊). 29(10): 1664-1676 (2022). PMID: 34238145. 

  54. F. Zhu, L. Y. Han, C. J. Zheng, B. Xie, M. T. Tammi, S. Y. Yang, Y. Q. Wei, Y. Z. Chen*. What are next generation innovative therapeutic targets? Clues from genetic, structural, physicochemical and system profiles of successful targets. Journal of Pharmacology and Experimental Therapeutics (impact factor of the publication year: 3.867, 医学二区 TOP 期刊). 330(1): 304-315 (2009). PMID: 19357322.
    55. Successful Validation of the Constructed Model:
    • Pasireotide targeting Somatostatin receptor 1 was approved by FDA in 2011.
    • Fingolimod targeting S1P receptor was approved by FDA in 2010.
    • Ecallantide targeting Plasma Kallikrein was approved by FDA in 2009.
    • Cinryze targeting C1 esterase was approved by FDA in 2009.
    • Icatibant targeting BK-2 receptor was approved by FDA in 2008.
    • Plerixafor targeting CXCR4 was approved by FDA in 2008.

  55. Q. X. Yang, Y. X. Wang, F. C. Li, S. Zhang, Y. C. Luo, Y. Li, J. Tang, B. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. Identification of the gene signature reflecting schizophrenia's etiology by constructing artificial intelligence-based method of enhanced reproducibility. CNS Neuroscience & Therapeutics (impact factor of the publication year: 3.394, 医学二区期刊). 25(9): 1054-1063 (2019). PMID: 31350824.
    56. Cover Article:

  56. Z. J. Han, W. W. Xue, L. Tao, F. Zhu*. Identification of novel immune-relevant drug target genes for alzheimer's disease by combining ontology inference with network analysis. CNS Neuroscience & Therapeutics (impact factor of the publication year: 3.495, 医学二区期刊). 24(12): 1253-1263 (2018). PMID: 30106219.
    57. Honors and Awards:
    • Wiley Top Cited Paper Award (2020).
    Cover Article:

  Licensed Patents and Copyrights
  1. F. Zhu, F. C. Li, H. C. Sun, J. Y. Yin. Software Copyright 2022SR1374536 approved by the National NCAC of China.
    A Software Tool for Metabolomics-based Quantitative Analysis of Large-scale and Long-term Microbiota Study (2022)

  2. F. Zhu, J. Y. Yin, F. C. Li, Y. Zhou, M. J. Mou, Y. J. Lu. Software Copyright 2022SR1374538 approved by the National NCAC of China.
    A Software Tool for Interaction Analysis of Drug-metabolizing Enzyme Intergroup (2022)

  3. F. Zhu, F. C. Li, J. Y. Yin, M. K. Lu, M. J. Mou. Software Copyright 2022SR1374548 approved by the National NCAC of China.
    A Software Tool for Molecular Profiling of Drug Interactions (2022)

  4. F. Zhu, F. C. Li, J. Y. Yin, M. K. Lu, Q. X. Yang. Software Copyright 2022SR1374537 approved by the National NCAC of China.
    A Software Tool for Stable Identification of Molecular Features based on OMICS Data (2022)

  5. F. Zhu, F. C. Li, J. Y. Yin, Y. Zhou, Y. Zhang. Software Copyright 2022SR1374547 approved by the National NCAC of China.
    A Software Tool for High Precision Identification of Biomarkers Based on Proteomics Technology (2022)

  6. F. Zhu, M. J. Mou, J. Tang, X. N. Sun. Software Copyright 2022SR1096571 approved by the National NCAC of China.
    A Software Tool for Analyzing Host Regulatory Factors of Human Microbiota (2022)

  7. F. Zhu, M. J. Mou, J. Tang, Y. X. Wang, et al. Software Copyright 2021SR0027303 approved by the National NCAC of China.
    A Software Tool for Selecting Metaproteomic Features Based on Performance Assessment (2021)

  8. F. Zhu, J. Y. Yin, F. C. Li, X. X. Li, et al. Software Copyright 2021SR0822567 approved by the National NCAC of China.
    A Software Tool for Constructing Phylogenetic Tree Describing the Homology among Drug Transporters (2021)

  9. F. Zhu, F. C. Li, Y. Zhou, X. Y. Zhang. Software Copyright 2021SR0826823 approved by the National NCAC of China.
    A Software Tool for Determining Sample Sufficiency for Comparative Biological Study (2021)

  10. F. Zhu, S. Zeng, J. Y. Yin, F. C. Li. Software Copyright 2020SR0275172 approved by the National NCAC of China.
    A Software Tool for Analyzing the Interplay among the Variabilities of Drug Transporters (2020)

  11. F. Zhu, Y. X. Wang, Y. Z. Chen, S. Zhang, et al. Software Copyright 2020SR0526446 approved by the National NCAC of China.
    A Software Tool for Integrating the Epigenetics with the Protein-Protein Interactions of Drug Target (2020)

  12. F. Zhu, Y. X. Wang, S. Zhang, F. C. Li, et al. Software Copyright 2020SR0527384 approved by the National NCAC of China.
    A Software Tool for Strictly Validating the Primary Drug Target and Conducting Network Analysis (2020)

  13. F. Zhu, Y. X. Wang, S. Zhang, F. C. Li, et al. Software Copyright 2020SR0528155 approved by the National NCAC of China.
    A Software Tool for Strictly Identifying the Primary Therapeutic Target of the Drugs in Clinical Trial (2020)

  14. F. Zhu, J. J. Hong, J. Hu, L. Tao. Software Copyright 2020SR0274064 approved by the National NCAC of China.
    A Software Tool for Discovering the Bacterial Type-IV Secreting System Effector Protein (2019)

  15. F. Zhu, J. Tang, J. B. Fu, Y. X. Wang. Software Copyright 2020SR0274135 approved by the National NCAC of China.
    A Software Tool for Assessing Label-free Proteome Quantification from Multiple Perspectives (2019)

  16. F. Zhu, F. C. Li, S. Zhang, Y. X. Wang, et al. Software Copyright 2020SR0525443 approved by the National NCAC of China.
    A Software Tool for Discovering the Novel Drug Scaffold Based on Biomarker Identification (2019)

  17. F. Zhu, F. C. Li, S. Zhang, Y. X. Wang, et al. Software Copyright 2020SR0528147 approved by the National NCAC of China.
    A Software Tool for Identifying the Tissue-Specific Distribution Pattern of Therapeutic Target (2018)

  18. F. Zhu, Q. X. Yang, B. Li, Y. X. Wang. Software Copyright 2020SR0275177 approved by the National NCAC of China.
    A Software Tool for Evaluating Mass-spectrometry-based Metabolomic Data from Multiple Perspectives (2017)

  19. F. Zhu, S. Zhang, F. C. Li, Y. X. Wang, et al. Software Copyright 2020SR0528618 approved by the National NCAC of China.
    A Software Tool for Associating the Disease-Relevant Signaling Pathway with Therapeutic Target (2016)
  Hosted Conference and Symposium
  Invited Speaker of International/Domestic Conference
  Reviewer of Esteemed Journals (12 Representative Journals)
Nucleic Acids Res (IF = 19.160); Med Res Rev (IF = 12.944); Br J Pharmacol (IF = 8.739);
Nat Protoc (IF = 17.021); Brief Bioinform (IF = 13.994); Bioinformatics (IF = 6.931);
Proc Natl Acad Sci U S A (IF = 12.779); Anal Chem (IF = 8.008); Mol Pharmaceut (IF = 5.364);
J Med Chem (IF = 8.039); Pharmacol Res (IF = 10.334); J Chem Inf Model (IF = 6.162)
  Associate Editor/Editorial Board Member/Topic Editor of Journals
Front Pharmacol (IF = 5.988); Comput Biol Med (IF = 6.698); J Alzheimers Dis (IF = 4.160);
Curr Gene Ther (IF = 4.676); Protein Pept Lett (IF = 1.927); Prog Pharm Sci (IF = N.A.)
CURRENT GROUP MEMBERS
PROFESSOR AND LECTURER
Wei-Wei XUE
Cheminformatics

2014.06-now

Personal Homepage Email

2016.09-Now: Assoc. Professor in School of Pharmaceutical Sciences, CQU

2014.06-2016.09: Lecturer in Innovative Drug Research Centre, CQU

2009.09-2014.06: Master, Doctor in Department of Chemistry, LZU

2005.09-2009.06: Bachelor in Department of Chemistry, LZU

DOCTORAL CANDIDATE

Yun-Xia Wang
Medicinal Chemistry

2018.09-now
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Jia-Yi Yin
Medicinal Chemistry

2018.09-now
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Yong-Chao Luo
Pharmacy

2018.07-now
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Ting-Ting Fu
Medicinal Chemistry

2019.09-now
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Feng-Cheng Li
Medicinal Chemistry

2020.03-now
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Ying Zhou
Pharmacy

2019.01-now
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GRADUATE STUDENT

Jing-Yi Yang
Medicinal Chemistry

2018.09-now
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Ying Zhang
Pharmacy

2019.01-now
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Min-Jie Mou
Pharmacy

2019.05-now
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Hong-Ning Zhang
Pharmacy

2019.07-now
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Yin-Tao Zhang
Pharmacy

2019.09-now
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Zhao Zhang
Medicinal Chemistry

2019.09-now
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Xiu-Na Sun
Pharmacy

2020.09-now
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Xi-Chen Lian
Pharmacy

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Kuerbannisha Amahong
Pharmacy

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Han-Yu Zhang
Pharmacy

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Xiao-Na Wang
Pharmacy

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Bin-Bin Xu
Pharmacy

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Ling-Yan Zheng
Pharmacy

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Huai-Cheng Sun
Pharmacy

2021.03-now
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Ming-Kun Lu
Pharmacy

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Shui-Yang Shi
Pharmacy

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Wei Zhang
Pharmacy

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Han-Yang Li
Pharmacy

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Zi-Qi Pan
Pharmacy

2022.09-now
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Zhen Chen
Pharmacy

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Teng Li
Pharmacy

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Nan-Xin You
Pharmacy

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Pharmacy

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CHINESE NATIONAL UNDERGRADUATE INNOVATIVE TEST PROGRAM AND STUDENT RESEARCH TRAINING PROGRAM

Kang-Li Chen
Pharmacy

2020.03-now
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Han-Xiang Xu
Pharmacy

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Pharmacy

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IDRB: Innovative Drug Research and Bioinformatics Group


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College of Pharmaceutical Sciences, Zhejiang University
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