Search Whole Database Search for Inter-species Structural Difference (ISD): Examples: MRP2; Sodium symporter family; ATP-Binding Cassette;ZIP4... Search for ISD by Model Organism Name: Please select a organism name Mus musculus (Mouse) Rattus norvegicus (Rat) Oryctolagus cuniculus (Rabbit) Cricetulus griseus (Chinese hamster) Danio rerio (Zebrafish) Canis lupus familiaris (Dog) Sus scrofa (Pig) Macaca fascicularis (Cynomolgus monkey) Gallus gallus (Chicken) Drosophila melanogaster (Fruit fly) Bos taurus (Bovine) Macaca mulatta (Rhesus macaque) Pongo abelii (Sumatran orangutan) Xenopus laevis (African clawed frog) Xenopus tropicalis (Western clawed frog) Cavia porcellus (Guinea pig) Equus caballus (Horse) Ovis aries (Sheep) Search for ISD by Transporter Names: Please select a transporter name ABCA1: ATP-binding cassette sub-family A member 1 ABCA2: ATP-binding cassette sub-family A member 2 ABCA3: ATP-binding cassette sub-family A member 3 ABCA5: ATP-binding cassette sub-family A member 5 ABCB5: ATP-binding cassette sub-family B member 5 ABCB6: ATP-binding cassette sub-family B member 6 ABCB8: ATP-binding cassette sub-family B member 8 AE2: Anion exchange protein 2 AE3: Anion exchange protein 3 AE4: Anion exchange protein 4 AGT1: Sodium-independent aspartate/glutamate transporter 1 ANT3: Adenine nucleotide translocator 3 ARALAR1: Calcium-binding mitochondrial carrier protein Aralar1 ARALAR2: Calcium-binding mitochondrial carrier protein Aralar2 ASBT: Apical sodium-dependent bile acid transporter ASC1: Asc-type amino acid transporter 1 ASCT1: Alanine/serine/cysteine/threonine transporter 1 ASCT2: Alanine/serine/cysteine/threonine transporter 2 AST: Vesicular H(+)/Aspartate-glutamate cotransporter ATB0+: Amino acid transporter ATB0+ ATP7B: Copper-transporting ATPase 2 B0AT1: Sodium-dependent neutral amino acid transporter B(0)AT1 B0AT3: Sodium-dependent neutral amino acid transporter B(0)AT3 BAT1: Glycoprotein-associated amino acid transporter b0, +AT1 BCRP: Breast cancer resistance protein BGT1: Na(+)/Cl(-) betaine/GABA transporter BSEP: Bile salt export pump CACT: Carnitine/acylcarnitine translocase CAT1: High affinity cationic amino acid transporter 1 CAT2: Cationic amino acid transporter 2 CAT3: Cationic amino acid transporter 3 CCC9: Cation-chloride cotransporter 9 CNT1: Concentrative nucleoside transporter 1 CNT2: Concentrative nucleoside transporter 2 CNT3: Concentrative Na(+)-nucleoside cotransporter 3 COPT2: Probable low affinity copper uptake protein 2 CRTR: Creatine transporter 1 CTL4: Choline transporter-like protein 4 CTR1: High affinity copper uptake protein 1 DAT1: Sodium-dependent dopamine transporter DIC: Mitochondrial dicarboxylate carrier EAAT1: Excitatory amino acid transporter 1 EAAT2: Excitatory amino acid transporter 2 EAAT3: Excitatory amino acid transporter 3 EAAT4: Excitatory amino acid transporter 4 EAAT5: Excitatory amino acid transporter 5 ENBT1: Equilibrative nucleobase transporter 1 ENT1: Equilibrative nucleoside transporter 1 ENT2: Equilibrative nucleoside transporter 2 ENT3: Equilibrative nucleoside transporter 3 ENT4: Equilibrative nucleoside transporter 4 FLIPT2: Fly-like putative transporter 2 FLOT1: Folate transporter 1 G3PP: Glycerol-3-phosphate permease GABT1: Sodium- and chloride-dependent GABA transporter 1 GAT2: Sodium- and chloride-dependent GABA transporter 2 GAT3: Sodium- and chloride-dependent GABA transporter 3 GC1: Mitochondrial glutamate carrier 1 GC2: Mitochondrial glutamate carrier 2 GLUT1: Glucose transporter type 1 GLUT12: Glucose transporter type 12 GLUT2: Glucose transporter type 2 GLUT3: Glucose transporter type 3 GLUT4: Glucose transporter type 4 GLUT5: Glucose transporter type 5 GLUT7: Glucose transporter type 7 GLUT8: Glucose transporter type 8 GLYT1: Sodium- and chloride-dependent glycine transporter 1 GLYT2: Sodium- and chloride-dependent glycine transporter 2 IREG1: Iron-regulated transporter 1 KCC1: Electroneutral potassium-chloride cotransporter 1 KCC2: Electroneutral potassium-chloride cotransporter 2 KCC3: Electroneutral potassium-chloride cotransporter 3 LAT1: L-type amino acid transporter 1 LAT2: L-type amino acid transporter 2 LAT3: L-type amino acid transporter 3 LAT4: L-type amino acid transporter 4 MATE1: Multidrug and toxin extrusion protein 1 MCT1: Monocarboxylate transporter 1 MCT10: Monocarboxylate transporter 10 MCT12: Monocarboxylate transporter 12 MCT2: Monocarboxylate transporter 2 MCT3: Monocarboxylate transporter 3 MCT4: Monocarboxylate transporter 4 MCT6: Monocarboxylate transporter 6 MCT9: Monocarboxylate transporter 9 MDR3: Multidrug resistance protein 3 MDU1: Lymphocyte activation antigen 4F2 MFT: Mitochondrial folate transporter/carrier MRP1: Multidrug resistance-associated protein 1 MRP2: Multidrug resistance-associated protein 2 MRP3: Multidrug resistance-associated protein 3 MRP4: Multidrug resistance-associated protein 4 MRP5: Multidrug resistance-associated protein 5 MRP6: Multidrug resistance-associated protein 6 MRP7: Multidrug resistance-associated protein 7 NaCT: Sodium-coupled citrate transporter NBAT: Neutral and basic amino acid transport protein rBAT NBC3: Sodium bicarbonate cotransporter 3 NBCe1: Electrogenic sodium bicarbonate cotransporter 1 NBCe2: Electrogenic sodium bicarbonate cotransporter 4 NCBE: Sodium-driven chloride bicarbonate exchanger NCC: Thiazide-sensitive sodium-chloride cotransporter NDCBE: Electroneutral sodium bicarbonate exchanger 1 NET: Sodium-dependent noradrenaline transporter NKCC1: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 NKCC2: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 NPC1L1: Niemann-Pick C1-like protein 1 NPT1: Sodium-dependent phosphate transport protein 1 NPT2C: Sodium-dependent phosphate transport protein 2C NPT3: Sodium-dependent phosphate transport protein 3 NRAMP2: Natural resistance-associated macrophage protein 2 NTCP: Sodium/taurocholate cotransporting polypeptide NTT4: Sodium-dependent neurotransmitter transporter OAT1: Organic anion transporter 1 OAT2: Organic anion transporter 2 OAT3: Organic anion transporter 3 OATP1C1: Organic anion transporting polypeptide 1C1 OATP2A1: Organic anion transporting polypeptide 2A1 OATP2B1: Organic anion transporting polypeptide 2B1 OATP3A1: Organic anion transporting polypeptide 3A1 OATP4A1: Organic anion transporting polypeptide 4A1 OATP4C1: Organic anion transporting polypeptide 4C1 OATP5A1: Organic anion transporting polypeptide 5A1 OCT1: Organic cation transporter 1 OCT2: Organic cation transporter 2 OCT3: Organic cation transporter 3 OCTL3: Organic cation transporter-like 3 OCTN1: Organic cation/carnitine transporter 1 OCTN2: Organic cation/carnitine transporter 2 ORNT2: Mitochondrial ornithine transporter 2 ORNT3: Mitochondrial ornithine transporter 3 OSTalpha: Organic solute transporter subunit alpha OSTbeta: Organic solute transporter subunit beta P-GP: P-glycoprotein 1 PAT1: Proton-coupled amino acid transporter 1 PAT2: Proton-coupled amino acid transporter 2 PAT3: Proton-coupled amino acid transporter 3 PAT4: Proton-coupled amino acid transporter 4 PCFT: Proton-coupled folate transporter PEPT1: Peptide transporter 1 PEPT2: Peptide transporter 2 PHC: Phosphate carrier protein PIT1: Sodium-dependent phosphate transporter 1 PIT2: Sodium-dependent phosphate transporter 2 PMP34: Peroxisomal membrane protein PMP34 PROT: Sodium-dependent proline transporter RALBP1: RalBP1-associated Eps domain-containing protein 2 RFVT2: Riboflavin transporter 3 RFVT3: Riboflavin transporter 2 RHBG: Ammonium transporter Rh type B RHGK: Ammonium transporter Rh type C SCAMC1: Calcium-binding mitochondrial carrier protein SCaMC-1 SCAMC2: Calcium-binding mitochondrial carrier protein SCaMC-2 SCAMC3: Calcium-binding mitochondrial carrier protein SCaMC-3 SERT: Sodium-dependent serotonin transporter SGLT1: Sodium/glucose cotransporter 1 SGLT2: Sodium/glucose cotransporter 2 SGLT4: Sodium/glucose cotransporter 4 SGLT5: Sodium/glucose cotransporter 5 SIT1: Sodium/imino-acid transporter 1 SLC17A4: Probable small intestine urate exporter SLC22A23: Solute carrier family 22 member 23 SLC26A6: Anion exchange transporter SLC26A9: Anion transporter/exchanger protein 9 SLC35F3: Putative thiamine transporter SLC35F3 SLC38A10: Putative sodium-coupled neutral amino acid transporter 10 SLC38A9: Sodium-coupled neutral amino acid transporter 9 SLC7A11: Cystine/glutamate transporter SLC7A6: Y+L amino acid transporter 2 SMCT1: Sodium-coupled monocarboxylate transporter 1 SMCT2: Sodium-coupled monocarboxylate transporter 2 SMIT: Sodium/myo-inositol cotransporter SMIT2: Sodium/myo-inositol cotransporter 2 SMVT: Sodium-dependent multivitamin transporter SNAT1: Sodium-coupled neutral amino acid transporter 1 SNAT2: Sodium-coupled neutral amino acid transporter 2 SNAT3: Sodium-coupled neutral amino acid transporter 3 SNAT4: Sodium-coupled neutral amino acid transporter 4 SNAT5: Sodium-coupled neutral amino acid transporter 5 SNAT6: Probable sodium-coupled neutral amino acid transporter 6 SNAT7: Putative sodium-coupled neutral amino acid transporter 7 SUR1: Sulfonylurea receptor 1 SUR2: Sulfonylurea receptor 2 SV2C: Synaptic vesicle glycoprotein 2C SVCT1: Sodium-dependent vitamin C transporter 1 SVCT2: Sodium-dependent vitamin C transporter 2 TAPL: TAP-like protein TAUT: Sodium- and chloride-dependent taurine transporter THTR1: Thiamine transporter 1 THTR2: Thiamine transporter 2 VACHT: Vesicular acetylcholine transporter VGLUT1: Vesicular glutamate transporter 1 VGLUT2: Vesicular glutamate transporter 2 VGLUT3: Vesicular glutamate transporter 3 VMAT1: Vesicular amine transporter 1 VMAT2: Vesicular amine transporter 2 ZIP11: Zrt- and Irt-like protein 11 ZIP4: Zrt- and Irt-like protein 4 ZNT8: Zinc transporter 8 ZNT9: Zinc transporter 9 Search for ISD by Transporter Families: Please select a transporter family Amino acid-polyamine-organocation (APC) Amino acid/auxin permease (AAAP) Ammonium transporter channel (AMT) Anion exchanger (AE) ATP-binding cassette (ABC) Bile acid:Na symporter (BASS) Cation diffusion facilitator (CDF) Cation-chloride cotransporter (CCC) Choline transporter-like (CTl) Concentrative nucleoside transporter (CNT) Copper transporter (CTR) Dicarboxylate/amino acid:cation symporter (DAACS) Divalent anion:Na symporter (DASS) Drug/metabolite transporter (DMT) Equilibrative nucleoside transporter (ENT) Eukaryotic riboflavin transporter (E-RFT) Ferroportin (FPN) Inorganic phosphate transporter (PIT) Major facilitator (MFS) Mitochondrial carrier (MC) Multidrug/oligosaccharidyl-lipid/polysaccharide flippase (MOPF) Natural resistance-associated macrophage (NRAMP) Neurotransmitter:sodium symporter (NSS) Non ABC multidrug exporter (N-MDE) Nucleobase/ascorbate transporter (NAT) Organic solute transporter (OST) Organo anion transporter (OAT) P-type ATPase (P-ATPase) Phosphate:Na symporter (PNAS) Proton-dependent oligopeptide transporter (POT) rBAT transport accessory protein (rBAT) Reduced folate carrier (RFC) Resistance-nodulation-cell division (RND) Solute:sodium symporter (SSS) Sulfate permease (SULP) Zinc-iron permease (ZIP) Search for ISD by ICD-11 Defined Disease Classes: Please select a disease class of drug 1A33: Cystoisosporiasis 1A60: Congenital syphilis 1B1Z: Tuberculosis 1B41: Heart rheumatic fever 1B51: Streptococcal pharyngitis 1B74: Superficial bacterial folliculitis 1B92: Glanders 1B97: Anthrax 1C10: Actinomycosis 1C2Z: Chlamydia infections 1C62: Human immunodeficiency virus infection 1D01: Infectious meningitis 1D82: Cytomegaloviral disease 1D92: Coronavirus infection 1E31: Influenza virus infection 1E51: Hepatitis virus infection 1E90: Varicella 1E91: Zoster 1F00: Herpes simplex virus infections 1F20: Aspergillosis 1F28: Dermatophytosis 1F57: Toxoplasmosis 1F6A: Onchocerciasis 1F6B: Strongyloidiasis 1G41: Sepsis 2A00: Brain cancer 2A20: Chronic myelogenous leukaemia 2A42: Juvenile myelomonocytic leukaemia 2A80: Follicular lymphoma 2A82: Leukaemic mature B-cell neoplasm 2A83: Multiple myeloma 2A85: Mantle cell lymphoma 2A8Z: Non hodgkin lymphoma 2A90: Mature T-cell lymphoma 2B0Z: Cutaneous T-cell lymphoma 2B30: Hodgkin lymphoma 2B33: Haematopoietic neoplasms 2B52: Ewing sarcoma 2B55: Rhabdomyosarcoma 2B57: Kaposi sarcoma 2B5B: Gastrointestinal stromal tumour 2B6B: Head and neck cancer 2B70: Oesophagus cancer 2B72: Stomach cancer 2B90: Colon cancer 2B91: Colorectal cancer 2C12: Liver/bile ducts cancer 2C25: Lung cancer 2C26: Pleural mesothelioma 2C30: Melanoma 2C35: Cutaneous sarcoma 2C60: Breast cancer 2C73: Ovarian cancer 2C80: Testicular cancer 2C82: Prostate cancer 2C90: Renal cancer 2C94: Bladder cancer 2D10: Thyroid cancer 4A40: Lupus erythematosus 4A42: Systemic sclerosis 4A80: Allergic/hypersensitivity disorder 5A00: Hypothyroidism 5A10: Diabetes mellitus 5A60: Pituitary gland hyperfunction 5A61: Pituitary gland hypofunction 5A74: Adrenocortical insufficiency 5B55: Vitamin deficiency 5B81: Obesity 5B91: Mineral excesses 5C55: Nucleotide metabolism disorder 5C72: Hypoosmolality/hyponatraemia 5C80: Hyperlipoproteinaemia 5C8Z: Lipoprotein metabolism disorder 6A05: Attention deficit hyperactivity disorder 6A60: Bipolar disorder 6A72: Dysthymic disorder 6A8Z: Depression 6C43: Drug dependence 7A0Z: Insomnia 8A00: Parkinsonism 8A02: Dystonic disorder 8A20: Alzheimer disease 8A6Z: Epilepsy/seizures 8A80: Migraine 8B11: Cerebral ischaemic stroke 8B60: Motor neuron disease 8C62: Lambert-Eaton syndrome 8C70: Muscular dystrophy 9A79: Keratoconjunctivitis sicca 9B10: Cataract 9C61: Glaucoma AB0Z: Otitis media BA00: Essential hypertension BA40: Angina pectoris BA41: Acute myocardial infarction BB00: Pulmonary thromboembolism BB01: Pulmonary hypertension BC71: Ventricular tachyarrhythmia BC9Z: Cardiac arrhythmia BD1Z: Heart failure BD71: Deep vein thrombosis BD72: Venous thromboembolism CA08: Vasomotor/allergic rhinitis CA20: Bronchitis CA22: Chronic obstructive pulmonary disease CA23: Asthma CA40: Pneumonia CB03: Idiopathic interstitial pneumonitis DA22: Gastrooesophageal reflux disease DA61: Peptic ulcer DD7Z: Inflammatory bowel diseases DD91: Irritable bowel syndrome EA80: Dermatitis EA90: Psoriasis EB00: Urticarial disorder EB40: Pemphigus FA01: Osteoarthritis FA20: Rheumatoid arthritis FA21: Psoriatic arthritis FA25: Gout FB83: Low bone mass disorder GA05: Female pelvic inflammation GA10: Endometriosis GA31: Female infertility GA90: Prostate hyperplasia GB61: Chronic kidney disease GC08: Urinary tract infection GC50: Functional bladder disorder HA01: Sexual arousal dysfunctions JA00: Abortion KD3A: Pregnancy termination LD28: Ehlers-Danlos syndrome MB24: Anxiety MD90: Nausea/vomiting ME05: Abnormal bowel habit MF50: Abnormal micturition MF55: Polyuria MG40: Shock NA07: Intracranial injury NE84: Organ transplant rejection
