TransporterID	Transporter Name	type	Epigenetic Phenomenon	Epigenetic Phenomenon_o	Order	ERVID	miRNA Stemloop ID	miRNA Mature ID	Sequence	Variations Type Disease	Variations Type	Variations_Type_	Disease	ICD11	Disease_	Tissue_	Tissue	Variations Location	miRNA target type	Histones location	Variations Frequency	Description	Discover Experiment	Experimental Material	Alteration Trend	Detect Experiment	Gene Case Median	Gene Control Median	Fold Change	Z-Score	P-value	ReferenceID	Fold_change_adj	Z-score_adj	P-value_adj	Fold_change_other	Z-score_other	P-value_other	order1	order2	order3	Figure_name
DTD0001	ABCC1	1	Hypoacetylation of ABCC1 in Breast cancer	Hypoacetylation of ABCC1 in Breast cancer	ag	EP38512	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60	Breast_cancer	tissue	tissue	Promoter	.	.	.	MRP1 overexpression in SN38-resistant T47D cells associated with the suppression of epigenetic gene silencing via DNA hypermethylation and histone deacetylation.	.	T47D/SN120 and T47D/SN150 breast cancer sublines	Up	RT-qPCR and Western blot	.	.	.	.	.	ref13330	.	.	.	.	.	.	.	.	.	.
DTD0002	ABCC2	1	Hypoacetylation of ABCC1 in Breast cancer	Hypoacetylation of ABCC1 in Breast cancer	ag	EP38512	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60	Breast_cancer	tissue	tissue	Promoter	.	.	.	MRP2 overexpression in SN38-resistant T47D cells associated with the suppression of epigenetic gene silencing via DNA hypermethylation and histone deacetylation.	.	T47D/SN120 and T47D/SN150 breast cancer sublines	Up	RT-qPCR and Western blot	.	.	.	.	.	ref13330	.	.	.	.	.	.	.	.	.	.
DTD0012	ABCC3	1	Hypoacetylation of ABCC1 in Breast cancer	Hypoacetylation of ABCC1 in Breast cancer	ag	EP38512	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60	Breast_cancer	tissue	tissue	Promoter	.	.	.	MRP3 overexpression in SN38-resistant T47D cells associated with the suppression of epigenetic gene silencing via DNA hypermethylation and histone deacetylation.	.	T47D/SN120 and T47D/SN150 breast cancer sublines	Up	RT-qPCR and Western blot	.	.	.	.	.	ref13330	.	.	.	.	.	.	.	.	.	.
DTD0015	ABCC4	1	Hypoacetylation of ABCC1 in Breast cancer	Hypoacetylation of ABCC1 in Breast cancer	ag	EP38512	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60	Breast_cancer	tissue	tissue	Promoter	.	.	.	MRP4 overexpression in SN38-resistant T47D cells associated with the suppression of epigenetic gene silencing via DNA hypermethylation and histone deacetylation.	.	T47D/SN120 and T47D/SN150 breast cancer sublines	Up	RT-qPCR and Western blot	.	.	.	.	.	ref13330	.	.	.	.	.	.	.	.	.	.
DTD0005	SLC22A7	1	Hypoacetylation of SLC22A7 in Hepatocellular carcinoma	Hypoacetylation of SLC22A7 in Hepatocellular carcinoma	ag	EP38513	.	.	.	Histone acetylation Hepatocellular carcinoma	Histone acetylation	Histone_acetylation	Hepatocellular carcinoma	2C12	Hepatocellular_carcinoma	tissue	tissue	Promoter	.	H3K18;H4K16	.	"Abnormal enrichment of sirtuin 7 (SIRT7), histone deacetylase 7 (HDAC7) and lysine acetyltransferase 8 (KAT8) at the promoter of OAT2 caused histone hypoacetylation and OAT2 downregulation."	.	SMMC-7721 HCC cells	Down	RT-qPCR	.	.	.	.	.	ref13331	.	.	.	.	.	.	.	.	.	.
DTD0019	SLC10A1	1	Loss of H3K27ac in SLC10A1 in Hepatocellular carcinoma	Loss of H3K27ac in SLC10A1 in Hepatocellular carcinoma	ag	EP38516	.	.	.	Histone acetylation Hepatocellular carcinoma	Histone acetylation	Histone_acetylation	Hepatocellular carcinoma	2C12	Hepatocellular_carcinoma	tissue	tissue	Promoter	.	H3K27	.	"hNTCP expression is downregulated in HCC due to loss of activating histone mark H3K27ac at the transcription start site. HDAC inhibitor treatment restores H3K27ac levels and GR binding, reactivating hNTCP expression and making cells susceptible to HBV infection."	.	"HepG2 cells, primary human hepatocytes, HCC tissues"	Down	RT-qPCR	.	.	.	.	.	ref13333	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	adb	EP10594	.	.	.	Histone acetylation Small cell lung cancer	Histone acetylation	Histone_acetylation	Small cell lung cancer	2C25.1	Small_cell_lung_cancer	tissue	tissue	Distal promoter (-981 to -817)	.	H4	.	High acetylation level of histone H3 of ABCB1 in etoposide-resistant small cell lung carcinoma associated with higher ABCB1 expression.	Chromatin immunoprecipitation	Human small cell lung carcinoma cell line (H69)	Down	RT-qPCR	.	.	.	.	.	ref1649	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	adb	EP10594	.	.	.	Histone acetylation Small cell lung cancer	Histone acetylation	Histone_acetylation	Small cell lung cancer	2C25.1	Small_cell_lung_cancer	tissue	tissue	Promoter (-981 to -817 and -222 to +37)	.	H3	.	"TSA induces downregulation of ABCB1 expression in drug-resistant SCLC cell line, independently of promoter methylation, and MBD1 or PCAF recruitment."	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1649	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	adb	EP10594	.	.	.	Histone acetylation Small cell lung cancer	Histone acetylation	Histone_acetylation	Small cell lung cancer	2C25.1	Small_cell_lung_cancer	tissue	tissue	Promoter (-981 to -817 and -222 to +37)	.	H4	.	"TSA induces downregulation of ABCB1 expression in drug-resistant SCLC cell line, independently of promoter methylation, and MBD1 or PCAF recruitment."	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1649	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	adb	EP10594	.	.	.	Histone acetylation Small cell lung cancer	Histone acetylation	Histone_acetylation	Small cell lung cancer	2C25.1	Small_cell_lung_cancer	tissue	tissue	Proximal promoter (+292 to +591)	.	H3	.	High acetylation level of histone H3 of ABCB1 in etoposide-resistant small cell lung carcinoma associated with higher ABCB1 expression.	Chromatin immunoprecipitation	Human small cell lung carcinoma cell line (H69)	Down	RT-qPCR	.	.	.	.	.	ref1649	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	Hypoacetylation of ABCB1 in SCLC (compare with etoposide-resistant counterpart cells)	adb	EP10594	.	.	.	Histone acetylation Small cell lung cancer	Histone acetylation	Histone_acetylation	Small cell lung cancer	2C25.1	Small_cell_lung_cancer	tissue	tissue	Proximal promoter (+292 to +591)	.	H4	.	High acetylation level of histone H4 of ABCB1 in etoposide-resistant small cell lung carcinoma associated with higher ABCB1 expression.	Chromatin immunoprecipitation	Human small cell lung carcinoma cell line (H69)	Down	RT-qPCR	.	.	.	.	.	ref1649	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in sarcoma (compare with multidrug-resistant counterpart cells)	Hypoacetylation of ABCB1 in sarcoma (compare with multidrug-resistant counterpart cells)	adb	EP10595	.	.	.	Histone acetylation Sarcoma	Histone acetylation	Histone_acetylation	Sarcoma	2A60.39	Sarcoma	tissue	tissue	968 bp upstream of exon 1	.	H3	.	The chromatin structure of the ABCB1 upstream promoter is changed via acetylation of histone H3 initiating ABCB1 activation.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1652	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in promyeloblastic leukemia (compare with valproate-treatment counterpart AML cells)	Hypoacetylation of ABCB1 in promyeloblastic leukemia (compare with valproate-treatment counterpart AML cells)	adf	EP10596	.	.	.	Histone acetylation Promyeloblastic leukemia	Histone acetylation	Histone_acetylation	Promyeloblastic leukemia	2A60.0	Promyeloblastic_leukemia	tissue	tissue	.	.	.	.	Exposure of promyeloblastic leukemia cells for 24 h to 2 mM of the weak histone deacetylase inhibitor phenylbutyrate resulted in enhanced and marked expression of P-glycoprotein.	Chromatin immunoprecipitation	Human leukemia stem cell-like cell line (KG-1a)	Down	RT-qPCR	.	.	.	.	.	ref3436	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in lymphoid tumour (compare with etoposide-resistant counterpart cells)	Hypoacetylation of ABCB1 in lymphoid tumour (compare with etoposide-resistant counterpart cells)	adb	EP10597	.	.	.	Histone acetylation Lymphoma	Histone acetylation	Histone_acetylation	Lymphoma	2B30	Lymphoma	tissue	tissue	Exon 1	.	H3	.	Histone H3 acetylation in the same CpG island was significantly increased in drug-resistant cell line.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1650	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in breast cancer (compare with doxorubicin-resistant counterpart cells)	Hypoacetylation of ABCB1 in breast cancer (compare with doxorubicin-resistant counterpart cells)	adb	EP10598	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60-2C6Z	Breast_cancer	tissue	tissue	Promoter	.	H3K9	.	Elevated level of lysine 9-acetylated histone H3 at the MDR1 promoter in doxorubicinresistant MCF-7 cells.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1648	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in AML (compare with valproate treatment counterpart cells)	Hypoacetylation of ABCB1 in AML (compare with valproate treatment counterpart cells)	adb	EP10599	.	.	.	Histone acetylation Acute myeloid leukemia	Histone acetylation	Histone_acetylation	Acute myeloid leukemia	2A60	Acute_myeloid_leukemia	tissue	tissue	Promoter	.	H3	.	Hyperacetylation of histone proteins in the promoter regions of MDR1 on valproate treatment.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref1651	.	.	.	.	.	.	.	.	.	.
DTD0003	ABCB1	1	Hypoacetylation of ABCB1 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	Hypoacetylation of ABCB1 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	adb	EP10600	.	.	.	Histone acetylation Acute myeloid leukemia	Histone acetylation	Histone_acetylation	Acute myeloid leukemia	2A60	Acute_myeloid_leukemia	tissue	tissue	Promoter	.	.	.	Chromatin immunoprecipitation revealed the hyperacetylation of histone proteins in the promoter regions of MDR1 on valproate treatment.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1651	.	.	.	.	.	.	.	.	.	.
DTD0014	Abcb11	1	Hyperacetylation of Abcb11 in liver (compare with kidney and cerebrum cells)	Hyperacetylation of Abcb11 in liver (compare with kidney and cerebrum cells)	ad	EP10315	.	.	.	Histone acetylation Rat liver	Histone acetylation	Histone_acetylation	Rat liver	.	Rat_liver	tissue	tissue	Promoter	.	H3	.	The histone H3 associated with Oatp1b2 promoters was hyperacetylated in the liver but was acetylated very little in the kidney and cerebrum.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3435	.	.	.	.	.	.	.	.	.	.
DTD0013	ABCB4	1	Hypoacetylation of ABCB4 in breast cancer (compare with doxorubicin-resistant counterpart cells)	Hypoacetylation of ABCB4 in breast cancer (compare with doxorubicin-resistant counterpart cells)	adb	EP10317	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60-2C6Z	Breast_cancer	tissue	tissue	Promoter	.	H3	.	"ABCB4 was overexpressed in doxorubicin-resistant breast cancer cells compared to their doxorubicin-sensitive counterparts, which was associated with reduced DNA methylation as well as increased histone acetylation at the ABCB4 promoter."	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3467	.	.	.	.	.	.	.	.	.	.
DTD0013	ABCB4	1	Hypoacetylation of ABCB4 in breast cancer (compare with doxorubicin-resistant counterpart cells)	Hypoacetylation of ABCB4 in breast cancer (compare with doxorubicin-resistant counterpart cells)	adb	EP10317	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60-2C6Z	Breast_cancer	tissue	tissue	Promoter	.	H4	.	"ABCB4 was overexpressed in doxorubicin-resistant breast cancer cells compared to their doxorubicin-sensitive counterparts, which was associated with reduced DNA methylation as well as increased histone acetylation at the ABCB4 promoter."	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3467	.	.	.	.	.	.	.	.	.	.
DTD0057	ABCC11	1	Hypoacetylation of ABCB11 in acute myeloid leukemia (compare with valproate treatment counterpart cells)	Hypoacetylation of ABCB11 in acute myeloid leukemia (compare with valproate treatment counterpart cells)	ad	EP09533	.	.	.	Histone acetylation Acute myeloid leukemia	Histone acetylation	Histone_acetylation	Acute myeloid leukemia	2A60	Acute_myeloid_leukemia	tissue	tissue	Promoter	.	H3;H3K9	.	"Chromatin immunoprecipitation revealed the hyperacetylation of histone proteins in the promoter regions of MDR1, BCRP, and MRP8 on valproate treatment."	Chromatin immunoprecipitation	Multiple cell lines of human	Up	RT-qPCR	.	.	.	.	.	ref1651	.	.	.	.	.	.	.	.	.	.
DTD0057	ABCC11	1	Hypoacetylation of ABCB11 in acute myeloid leukemia (compare with valproate treatment counterpart cells)	Hypoacetylation of ABCB11 in acute myeloid leukemia (compare with valproate treatment counterpart cells)	ad	EP09533	.	.	.	Histone acetylation Acute myeloid leukemia	Histone acetylation	Histone_acetylation	Acute myeloid leukemia	2A60	Acute_myeloid_leukemia	tissue	tissue	Promoter	.	H4	.	"Chromatin immunoprecipitation revealed the hyperacetylation of histone proteins in the promoter regions of MDR1, BCRP, and MRP8 on valproate treatment."	Chromatin immunoprecipitation	Multiple cell lines of human	Up	RT-qPCR	.	.	.	.	.	ref1651	.	.	.	.	.	.	.	.	.	.
DTD0061	ABCC8	1	Hypoacetylation of ABCC8 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	Hypoacetylation of ABCC8 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	adb	EP09531	.	.	.	Histone acetylation Acute myeloid leukemia	Histone acetylation	Histone_acetylation	Acute myeloid leukemia	2A60	Acute_myeloid_leukemia	tissue	tissue	Promoter	.	.	.	Chromatin immunoprecipitation revealed the hyperacetylation of histone proteins in the promoter regions of MRP8 on valproate treatment.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1651	.	.	.	.	.	.	.	.	.	.
DTD0061	ABCC8	1	Hypoacetylation of ABCC8 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	Hypoacetylation of ABCC8 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	adf	EP09531	.	.	.	Histone acetylation Promyeloblastic leukemia	Histone acetylation	Histone_acetylation	Promyeloblastic leukemia	2A60.0	Promyeloblastic_leukemia	tissue	tissue	.	.	.	.	Exposure of promyeloblastic leukemia cells for 24 h to 2 mM of the weak histone deacetylase inhibitor phenylbutyrate resulted in enhanced and marked expression of MRP8.	Chromatin immunoprecipitation	Human leukemia stem cell-like cell line (KG-1a)	Down	RT-qPCR	.	.	.	.	.	ref3436	.	.	.	.	.	.	.	.	.	.
DTD0004	ABCG2	1	Hypoacetylation of ABCG2 in colon cancer (compare with romidepsin-resistant counterpart cells)	Hypoacetylation of ABCG2 in colon cancer (compare with romidepsin-resistant counterpart cells)	adb	EP10544	.	.	.	Histone acetylation Colon cancer	Histone acetylation	Histone_acetylation	Colon cancer	2B90	Colon_cancer	tissue	tissue	Promoter	.	H3	.	High acetylation level of histone H3 of ABCG2 in romidepsin-resistant colon cancer cells associated with higher ABCG2 expression.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1702	.	.	.	.	.	.	.	.	.	.
DTD0004	ABCG2	1	Hypoacetylation of ABCG2 in breast cancer (compare with doxorubicin-resistant counterpart cells)	Hypoacetylation of ABCG2 in breast cancer (compare with doxorubicin-resistant counterpart cells)	adb	EP10545	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60-2C6Z	Breast_cancer	tissue	tissue	Promoter	.	H3	.	High acetylation level of histone H3 of ABCG2 in doxorubicin-resistant breast cancer cells associated with higher ABCG2 expression.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1703	.	.	.	.	.	.	.	.	.	.
DTD0004	ABCG2	1	Hypoacetylation of ABCG2 in AML (compare with valproate treatment counterpart cells)	Hypoacetylation of ABCG2 in AML (compare with valproate treatment counterpart cells)	adb	EP10546	.	.	.	Histone acetylation Acute myeloid leukemia	Histone acetylation	Histone_acetylation	Acute myeloid leukemia	2A60	Acute_myeloid_leukemia	tissue	tissue	Promoter	.	H3K9	.	Hyperacetylation of histone proteins in the promoter regions of BCRP on valproate treatment.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref1651	.	.	.	.	.	.	.	.	.	.
DTD0004	ABCG2	1	Hypoacetylation of ABCG2 in AML (compare with valproate treatment counterpart cells)	Hypoacetylation of ABCG2 in AML (compare with valproate treatment counterpart cells)	adb	EP10546	.	.	.	Histone acetylation Acute myeloid leukemia	Histone acetylation	Histone_acetylation	Acute myeloid leukemia	2A60	Acute_myeloid_leukemia	tissue	tissue	Promoter	.	H4	.	Hyperacetylation of histone proteins in the promoter regions of BCRP on valproate treatment.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref1651	.	.	.	.	.	.	.	.	.	.
DTD0004	ABCG2	1	Hypoacetylation of ABCG2 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	Hypoacetylation of ABCG2 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	adb	EP10547	.	.	.	Histone acetylation Acute myeloid leukemia	Histone acetylation	Histone_acetylation	Acute myeloid leukemia	2A60	Acute_myeloid_leukemia	tissue	tissue	Promoter	.	.	.	Chromatin immunoprecipitation revealed the?hyperacetylation?of?histone?proteins in the promoter regions of?BCRP on valproate treatment.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref1651	.	.	.	.	.	.	.	.	.	.
DTD0004	ABCG2	1	Hypoacetylation of ABCG2 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	Hypoacetylation of ABCG2 in acute myeloid leukemia (compare with valproate-treatment counterpart AML cells)	adf	EP10547	.	.	.	Histone acetylation Promyeloblastic leukemia	Histone acetylation	Histone_acetylation	Promyeloblastic leukemia	2A60.0	Promyeloblastic_leukemia	tissue	tissue	.	.	.	.	Exposure of promyeloblastic leukemia cells for 24 h to 2 mM of the weak histone deacetylase inhibitor phenylbutyrate resulted in enhanced and marked expression of BCRP.	Chromatin immunoprecipitation	Human leukemia stem cell-like cell line (KG-1a)	Down	RT-qPCR	.	.	.	.	.	ref3436	.	.	.	.	.	.	.	.	.	.
DTD0020	Slc10a2	1	Hyperacetylation of Slc10a2 in liver (compare with kidney and cerebrum cells)	Hyperacetylation of Slc10a2 in liver (compare with kidney and cerebrum cells)	ad	EP10121	.	.	.	Histone acetylation Rat liver	Histone acetylation	Histone_acetylation	Rat liver	.	Rat_liver	tissue	tissue	Promoter	.	H3	.	The histone H3 associated with Oatp1b2 promoters was hyperacetylated in the liver but was acetylated very little in the kidney and cerebrum.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3435	.	.	.	.	.	.	.	.	.	.
DTD0083	Slc12a2	1	Hypoacetylation of Slc12a2 in hypertension (compare with Ang II-treatment counterpart hypertension rats)	Hypoacetylation of Slc12a2 in hypertension (compare with Ang II-treatment counterpart hypertension rats)	adb	EP09082	.	.	.	Histone acetylation Hypertension	Histone acetylation	Histone_acetylation	Hypertension	BA00-BA04	Hypertension	tissue	tissue	Promoter	.	H3	.	Slc12a2 is upregulated via histone modification in the aortas of Ang II-induced hypertensive SD rats.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	RT-qPCR	.	.	.	.	.	ref3441	.	.	.	.	.	.	.	.	.	.
DTD0083	Slc12a2	1	Hyperacetylation of Slc12a2 in hypertension (compare with normal rats)	Hyperacetylation of Slc12a2 in hypertension (compare with normal rats)	ad	EP09083	.	.	.	Histone acetylation Hypertension	Histone acetylation	Histone_acetylation	Hypertension	BA00-BA04	Hypertension	tissue	tissue	Promoter	.	H3K4	.	The increased levels of mRNA expression correlated with increment of acetylation on H3K4 at the Slc12a2 promoter region in spontaneously hypertensive rat.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3438	.	.	.	.	.	.	.	.	.	.
DTD0086	Slc12a5	1	Hypoacetylation of Slc12a5 in inflammatory pain (compare with normal rats)	Hypoacetylation of Slc12a5 in inflammatory pain (compare with normal rats)	adb	EP09034	.	.	.	Histone acetylation Inflammatory pain	Histone acetylation	Histone_acetylation	Inflammatory pain	MG30.42	Inflammatory_pain	tissue	tissue	Promoter	.	H3	.	Promoter histone acetylation plays a role in complete Freund's adjuvantinduced suppression of SLC12A5 in the spinal dorsal horn.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3454	.	.	.	.	.	.	.	.	.	.
DTD0086	Slc12a5	1	Hypoacetylation of Slc12a5 in inflammatory pain (compare with normal rats)	Hypoacetylation of Slc12a5 in inflammatory pain (compare with normal rats)	adb	EP09034	.	.	.	Histone acetylation Inflammatory pain	Histone acetylation	Histone_acetylation	Inflammatory pain	MG30.42	Inflammatory_pain	tissue	tissue	Promoter	.	H4	.	Promoter histone acetylation plays a role in complete Freund's adjuvantinduced suppression of SLC12A5 in the spinal dorsal horn.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3454	.	.	.	.	.	.	.	.	.	.
DTD0086	Slc12a5	1	Hypoacetylation of Slc12a5 in bone cancer pain (compare with normal rats)	Hypoacetylation of Slc12a5 in bone cancer pain (compare with normal rats)	adb	EP09035	.	.	.	Histone acetylation Bone cancer pain	Histone acetylation	Histone_acetylation	Bone cancer pain	MG30.1	Bone_cancer_pain	tissue	tissue	Promoter	.	.	.	Suppression of HDAC2 in spinal cord alleviates mechanical hyperalgesia and restores KCC2 expression in a rat model of bone cancer pain.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3466	.	.	.	.	.	.	.	.	.	.
DTD0100	Slc16a1	1	Hypoacetylation of Slc16a1 in oligodendrocyte precursors (compare with oligodendrocyte)	Hypoacetylation of Slc16a1 in oligodendrocyte precursors (compare with oligodendrocyte)	ad	EP08723	.	.	.	Histone acetylation Oligodendrocyte precursors	Histone acetylation	Histone_acetylation	Oligodendrocyte precursors	.	Oligodendrocyte_precursors	tissue	tissue	Promoter	.	H3K9	.	There was a significant negative correlation between H3K9ac in the Slc16a1 promoter and Slc16a1 expression.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3464	.	.	.	.	.	.	.	.	.	.
DTD0111	SLC16A7	1	Hypoacetylation of SLC16A7 in breast cancer (compare with beta-hydroxybutyrate-treatment counterpart cells)	Hypoacetylation of SLC16A7 in breast cancer (compare with beta-hydroxybutyrate-treatment counterpart cells)	adf	EP08322	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60-2C6Z	Breast_cancer	tissue	tissue	.	.	H3K9	.	"Treatment with -hydroxybutyrate, breast cancer cells expressing MCT2 increase the global histone H3K9 acetylation and upregulate several tumour-promoting genes."	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3459	.	.	.	.	.	.	.	.	.	.
DTD0128	SLC19A3	1	Hypoacetylation of SLC19A3 in colon cancer (compare with trichostatin A-treatment counterpart cells)	Hypoacetylation of SLC19A3 in colon cancer (compare with trichostatin A-treatment counterpart cells)	adb	EP08027	.	.	.	Histone acetylation Colon cancer	Histone acetylation	Histone_acetylation	Colon cancer	2B90	Colon_cancer	tissue	tissue	Promoter	.	H3	.	TSA treatment increased histone H3 acetylation of SLC19A3 promoter region in all 4 colon cancer cell lines examined.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3440	.	.	.	.	.	.	.	.	.	.
DTD0128	SLC19A3	1	Hypoacetylation of SLC19A3 in colon cancer (compare with TSA-treatment counterpart cells)	Hypoacetylation of SLC19A3 in colon cancer (compare with TSA-treatment counterpart cells)	adb	EP10665	.	.	.	Histone acetylation Colon cancer	Histone acetylation	Histone_acetylation	Colon cancer	2B90	Colon_cancer	tissue	tissue	Promoter	.	.	.	"In the 4 colon cancer cells examined, SLC19A3 mRNA expression is down-regulated by histone deacetylation."	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3440	.	.	.	.	.	.	.	.	.	.
DTD0133	SLC1A5	1	Hyperacetylation of SLC1A5 in chronic social defeat stress (compare with normal control mice)	Hyperacetylation of SLC1A5 in chronic social defeat stress (compare with normal control mice)	ad	EP07787	.	.	.	Histone acetylation Chronic social defeat stress	Histone acetylation	Histone_acetylation	Chronic social defeat stress	QE01	Chronic_social_defeat_stress	tissue	tissue	Promoter	.	H3K9	.	Chronic social stress activates ASCT2 transcription via histone acetylation in its promoter.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3460	.	.	.	.	.	.	.	.	.	.
DTD0133	SLC1A5	1	Hyperacetylation of SLC1A5 in chronic social defeat stress (compare with normal control mice)	Hyperacetylation of SLC1A5 in chronic social defeat stress (compare with normal control mice)	ad	EP07787	.	.	.	Histone acetylation Chronic social defeat stress	Histone acetylation	Histone_acetylation	Chronic social defeat stress	QE01	Chronic_social_defeat_stress	tissue	tissue	Promoter	.	H3K27	.	Chronic social stress activates ASCT2 transcription via histone acetylation in its promoter.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3460	.	.	.	.	.	.	.	.	.	.
DTD0006	SLC22A2	1	Hypoacetylation of SLC22A2 in renal cell carcinoma	Hypoacetylation of SLC22A2 in renal cell carcinoma	adb	EP10490	.	.	.	Histone acetylation Renal cell carcinoma	Histone acetylation	Histone_acetylation	Renal cell carcinoma	2C90	Renal_cell_carcinoma	tissue	tissue	Promoter	.	H3K18	.	"Combined treatment using the DNA methylation inhibitor decitabine and the histone deacetylase inhibitor vorinostat significantly increased the expression of OCT2 in RCC cell lines, which sensitized these cells to oxaliplatin."	Chromatin immunoprecipitation	Patients samples of human; Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3473	.	.	.	.	.	.	.	.	.	.
DTD0006	SLC22A2	1	Hypoacetylation of SLC22A2 in renal cell carcinoma	Hypoacetylation of SLC22A2 in renal cell carcinoma	adb	EP10490	.	.	.	Histone acetylation Renal cell carcinoma	Histone acetylation	Histone_acetylation	Renal cell carcinoma	2C90	Renal_cell_carcinoma	tissue	tissue	Promoter	.	H3K27	.	"Combined treatment using the DNA methylation inhibitor decitabine and the histone deacetylase inhibitor vorinostat significantly increased the expression of OCT2 in RCC cell lines, which sensitized these cells to oxaliplatin."	Chromatin immunoprecipitation	Patients samples of human; Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3473	.	.	.	.	.	.	.	.	.	.
DTD0005	SLC22A7	1	Hypoacetylation of  SLC22A7 in Hepatocellular carcinoma (compare with non-tumor adjacent tissue)	Hypoacetylation of  SLC22A7 in Hepatocellular carcinoma (compare with non-tumor adjacent tissue)	ab	EP20000	.	.	.	Histone acetylation Hepatocellular carcinoma	Histone acetylation	Histone_acetylation	Hepatocellular carcinoma	2C12.02	Hepatocellular_carcinoma	tissue	tissue	Promoter	.	H3K18	.	Significant increases in SLC22A7 mRNA were observed when these cancer cells were cultured in the presence of histone deacetylase (HDAC) inhibitors.	RT-qPCR	Hepatocellular carcinoma cell lines (BEL-7402 and SMMC-7721)	Down	Western Blot	.	.	.	.	.	ref6001	.	.	.	.	.	.	.	.	.	.
DTD0158	SLC23A1	1	Hypoacetylation of SLC23A1 in colon (compare with jejunum tissue of human)	Hypoacetylation of SLC23A1 in colon (compare with jejunum tissue of human)	adb	EP07375	.	.	.	Histone acetylation Colon	Histone acetylation	Histone_acetylation	Colon	.	Colon	tissue	tissue	Promoter	.	H3K9	.	Lower levels of H3 acethylation of lysine 9 and lower gene expression was observed in the SLC23A1 promoter in the colon.	Chromatin immunoprecipitation	Patients samples of human	Down	RT-qPCR	.	.	.	.	.	ref3456	.	.	.	.	.	.	.	.	.	.
DTD0159	SLC23A2	1	Hypoacetylation of SLC23A2 in colon (compare with jejunum tissue of human)	Hypoacetylation of SLC23A2 in colon (compare with jejunum tissue of human)	adb	EP07343	.	.	.	Histone acetylation Colon	Histone acetylation	Histone_acetylation	Colon	.	Colon	tissue	tissue	Promoter	.	H3K9	.	Lower levels of H3 acethylation of lysine 9 and lower gene expression was observed in the SLC23A2 promoter in the colon.	Chromatin immunoprecipitation	Patients samples of human	Down	RT-qPCR	.	.	.	.	.	ref3456	.	.	.	.	.	.	.	.	.	.
DTD0170	SLC25A12	1	Hyperacetylation of SLC25A12 in hepatocellular carcinoma (compare with normal human hepatocytes)	Hyperacetylation of SLC25A12 in hepatocellular carcinoma (compare with normal human hepatocytes)	ad	EP07085	.	.	.	Histone acetylation Hepatocellular carcinoma	Histone acetylation	Histone_acetylation	Hepatocellular carcinoma	2C12.02	Hepatocellular_carcinoma	tissue	tissue	Promoter	.	H3	.	SLC25A12 is epigenetically induced in HCC by mechanisms involving histone acetylation but not DNA methylation.	Chromatin immunoprecipitation	Human hepatocellular carcinoma cell line (HepG2)	Up	Western Blot	.	.	.	.	.	ref0805	.	.	.	.	.	.	.	.	.	.
DTD0170	SLC25A12	1	Hyperacetylation of SLC25A12 in hepatocellular carcinoma (compare with normal human hepatocytes)	Hyperacetylation of SLC25A12 in hepatocellular carcinoma (compare with normal human hepatocytes)	ad	EP07085	.	.	.	Histone acetylation Hepatocellular carcinoma	Histone acetylation	Histone_acetylation	Hepatocellular carcinoma	2C12.02	Hepatocellular_carcinoma	tissue	tissue	Promoter	.	H4	.	SLC25A12 is epigenetically induced in HCC by mechanisms involving histone acetylation but not DNA methylation.	Chromatin immunoprecipitation	Human hepatocellular carcinoma cell line (HepG2)	Up	Western Blot	.	.	.	.	.	ref0805	.	.	.	.	.	.	.	.	.	.
DTD0230	SLC26A2	1	Hypoacetylation of SLC26A2 in colon cancer (compare with normal counterpart cells)	Hypoacetylation of SLC26A2 in colon cancer (compare with normal counterpart cells)	adb	EP06119	.	.	.	Histone acetylation Colon cancer	Histone acetylation	Histone_acetylation	Colon cancer	2B90	Colon_cancer	tissue	tissue	Promoter	.	H3K9	.	Significant increases in SLC26A2 mRNA were observed when these cancer cells were cultured in the presence of histone deacetylase (HDAC) inhibitors.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3437	.	.	.	.	.	.	.	.	.	.
DTD0245	SLC28A2	1	Hypoacetylation of SLC28A2 in colorectal cancer	Hypoacetylation of SLC28A2 in colorectal cancer	adb	EP05685	.	.	.	Histone acetylation Colorectal cancer	Histone acetylation	Histone_acetylation	Colorectal cancer	2B91	Colorectal_cancer	tissue	tissue	Promoter	.	H3K9	.	Histone hypoacetylation due to increased levels of histone deacetylase 7 results in CNT2 repression in CRC tumour tissue and could lead to decreased uptake of and consequent resistance to nucleoside anti-cancer agents.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref1747	.	.	.	.	.	.	.	.	.	.
DTD0245	SLC28A2	1	Hypoacetylation of SLC28A2 in colorectal cancer	Hypoacetylation of SLC28A2 in colorectal cancer	adb	EP05685	.	.	.	Histone acetylation Colorectal cancer	Histone acetylation	Histone_acetylation	Colorectal cancer	2B91	Colorectal_cancer	tissue	tissue	Promoter	.	H3K18	.	Histone hypoacetylation due to increased levels of histone deacetylase 7 results in CNT2 repression in CRC tumour tissue and could lead to decreased uptake of and consequent resistance to nucleoside anti-cancer agents.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref1747	.	.	.	.	.	.	.	.	.	.
DTD0245	SLC28A2	1	Hypoacetylation of SLC28A2 in colorectal cancer	Hypoacetylation of SLC28A2 in colorectal cancer	adb	EP05685	.	.	.	Histone acetylation Colorectal cancer	Histone acetylation	Histone_acetylation	Colorectal cancer	2B91	Colorectal_cancer	tissue	tissue	Promoter	.	H4	.	Histone hypoacetylation due to increased levels of histone deacetylase 7 results in CNT2 repression in CRC tumour tissue and could lead to decreased uptake of and consequent resistance to nucleoside anti-cancer agents.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref1747	.	.	.	.	.	.	.	.	.	.
DTD0251	SLC2A1	1	Hypoacetylation of SLC2A1 in rat brain astrocytes (compare with valproic acid treatment counterpart cells)	Hypoacetylation of SLC2A1 in rat brain astrocytes (compare with valproic acid treatment counterpart cells)	adb	EP05470	.	.	.	Histone acetylation Rat brain astrocyte	Histone acetylation	Histone_acetylation	Rat brain astrocyte	.	Rat_brain_astrocyte	tissue	tissue	Promoter	.	.	.	Valproic acid could increase SLC2A1 gene expression by increasing histone acetylation at the SLC2A1 promotor.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	RT-qPCR	.	.	.	.	.	ref3442	.	.	.	.	.	.	.	.	.	.
DTD0251	SLC2A1	1	Hyperacetylation of SLC2A1 in fasted mice brain (compare with normal counterpart cells)	Hyperacetylation of SLC2A1 in fasted mice brain (compare with normal counterpart cells)	ad	EP05472	.	.	.	Histone acetylation Mice brain	Histone acetylation	Histone_acetylation	Mice brain	.	Mice_brain	tissue	tissue	Promoter	.	H3K9	.	Fasting-induced production of the ketone body -hydroxybutyrate (-OHB) enhances expression of the glucose transporter gene Slc2a1 (Glut1) via histone modification.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3457	.	.	.	.	.	.	.	.	.	.
DTD0257	SLC2A2	1	Hypoacetylation of SLC2A2 in type 2 diabetes (compare with counterpart normal rat cells)	Hypoacetylation of SLC2A2 in type 2 diabetes (compare with counterpart normal rat cells)	adb	EP05265	.	.	.	Histone acetylation Type 2 diabetes	Histone acetylation	Histone_acetylation	Type 2 diabetes	5A11	Type_2_diabetes	tissue	tissue	Promoter	.	H3	.	Decreased H3 acetylation basically was correlated with decreased Glut2 gene expression.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	RT-qPCR	.	.	.	.	.	ref3449	.	.	.	.	.	.	.	.	.	.
DTD0257	Slc2a2	1	Hyperacetylation of Slc2a2 in high concentrations of glucose (compare with low concentrations of glucose counterpart cells)	Hyperacetylation of Slc2a2 in high concentrations of glucose (compare with low concentrations of glucose counterpart cells)	ad	EP05267	.	.	.	Histone acetylation High concentrations of glucose	Histone acetylation	Histone_acetylation	High concentrations of glucose	.	High_concentrations_of_glucose	tissue	tissue	Promoter	.	H4	.	High levels of glucose (30 mM) cause hyperacetylation of histone H4 at both insulin and Slc2a2 gene promoters in MIN6 cells.	Chromatin immunoprecipitation	Mouse insulinoma 6 cells	Up	RT-qPCR	.	.	.	.	.	ref3433	.	.	.	.	.	.	.	.	.	.
DTD0258	SLC2A3	1	Hypoacetylation of SLC2A3 in non-small cell lung cancer (compare with Vorinostat-treatment counterpart cells)	Hypoacetylation of SLC2A3 in non-small cell lung cancer (compare with Vorinostat-treatment counterpart cells)	adb	EP05252	.	.	.	Histone acetylation Non-small cell lung cancer	Histone acetylation	Histone_acetylation	Non-small cell lung cancer	2C25.4	Non-small_cell_lung_cancer	tissue	tissue	Promoter	.	.	.	SLC2A3 expression can be induced or increased following inhibition of histone deacetylases in non-small cell lung cancer cell lines.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3446	.	.	.	.	.	.	.	.	.	.
DTD0262	SLC2A4	1	Hypoacetylation of SLC2A4 in type 2 diabete (compare with counterpart normal rat cells)	Hypoacetylation of SLC2A4 in type 2 diabete (compare with counterpart normal rat cells)	adb	EP05188	.	.	.	Histone acetylation Type 2 diabetes	Histone acetylation	Histone_acetylation	Type 2 diabetes	5A11	Type_2_diabetes	tissue	tissue	Promoter	.	H3	.	The Type 2 diabetes reduced the H3Kac which would decrease the binding of transcription factors.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3469	.	.	.	.	.	.	.	.	.	.
DTD0262	SLC2A4	1	Hypoacetylation of SLC2A4 in type 1 diabete (compare with counterpart normal rat cells)	Hypoacetylation of SLC2A4 in type 1 diabete (compare with counterpart normal rat cells)	adb	EP05189	.	.	.	Histone acetylation Type 1 diabetes	Histone acetylation	Histone_acetylation	Type 1 diabetes	5A10	Type_1_diabetes	tissue	tissue	Promoter	.	H3	.	The Type 1 diabetes reduced the H3Kac which would decrease the binding of transcription factors.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3469	.	.	.	.	.	.	.	.	.	.
DTD0262	SLC2A4	1	Hypoacetylation of SLC2A4 in non-small cell lung cancer (compare with Vorinostat-treatment counterpart cells)	Hypoacetylation of SLC2A4 in non-small cell lung cancer (compare with Vorinostat-treatment counterpart cells)	adb	EP05190	.	.	.	Histone acetylation Non-small cell lung cancer	Histone acetylation	Histone_acetylation	Non-small cell lung cancer	2C25.4	Non-small_cell_lung_cancer	tissue	tissue	Promoter	.	.	.	SLC2A4 expression can be induced or increased following inhibition of histone deacetylases in non-small cell lung cancer cell lines.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3446	.	.	.	.	.	.	.	.	.	.
DTD0263	SLC2A5	1	Hypoacetylation of SLC2A5 in fructose force-fed mice (compare with glucose force-fed mice)	Hypoacetylation of SLC2A5 in fructose force-fed mice (compare with glucose force-fed mice)	ad	EP05144	.	.	.	Histone acetylation Fructose-fed mice	Histone acetylation	Histone_acetylation	Fructose-fed mice	.	Fructose-fed_mice	tissue	tissue	Promoter	.	H3	.	Jejunal expression of Slc2a5 by fructose force-feeding involved inducing the acetylation of histone H3 at K9 and of H4 at K5/16 around the Slc2a5 gene.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3445	.	.	.	.	.	.	.	.	.	.
DTD0263	SLC2A5	1	Hypoacetylation of SLC2A5 in fructose force-fed mice (compare with glucose force-fed mice)	Hypoacetylation of SLC2A5 in fructose force-fed mice (compare with glucose force-fed mice)	ad	EP05144	.	.	.	Histone acetylation Fructose-fed mice	Histone acetylation	Histone_acetylation	Fructose-fed mice	.	Fructose-fed_mice	tissue	tissue	Promoter	.	H4	.	Jejunal expression of Slc2a5 by fructose force-feeding involved inducing the acetylation of histone H3 at K9 and of H4 at K5/16 around the Slc2a5 gene.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3445	.	.	.	.	.	.	.	.	.	.
DTD0329	SLC38A2	1	Hyperacetylation of SLC38A2 in activated amino acid response signaling pathways (compare with unfolded protein response signaling pathways)	Hyperacetylation of SLC38A2 in activated amino acid response signaling pathways (compare with unfolded protein response signaling pathways)	ad	EP03655	.	.	.	Histone acetylation Activated amino acid response signaling pathways	Histone acetylation	Histone_acetylation	Activated amino acid response signaling pathways	.	Activated_amino_acid_response_signaling_pathways	tissue	tissue	Promoter	.	H3	.	Hyperacetylation of histone H3 and recruitment of the general transcription factors at the HepG2 SLC38A2 promoter occurred in response to the activated amino acid but not the unfolded protein.	Chromatin immunoprecipitation	Human hepatocellular carcinoma cell line (HepG2)	Up	RT-qPCR	.	.	.	.	.	ref3434	.	.	.	.	.	.	.	.	.	.
DTD0331	SLC38A4	1	Hypocetylation of SLC38A4 in retinoic acid receptors (RAR) expression cells (compare with counterpart RAR knockout cells)	Hypocetylation of SLC38A4 in retinoic acid receptors (RAR) expression cells (compare with counterpart RAR knockout cells)	adb	EP03553	.	.	.	Histone acetylation Retinoic acid receptors (RAR) expression cells	Histone acetylation	Histone_acetylation	Retinoic acid receptors (RAR) expression cells	.	Retinoic_acid_receptors_(RAR)_expression_cells	tissue	tissue	Promoter	.	H3K9	.	Increased SLC38A4 transcript levels was associated with decreased promoter CpG-island methylation and increased permissive histone modifications (H3K9/K14ac) in RAR knockout cells.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3439	.	.	.	.	.	.	.	.	.	.
DTD0331	SLC38A4	1	Hypocetylation of SLC38A4 in retinoic acid receptors (RAR) expression cells (compare with counterpart RAR knockout cells)	Hypocetylation of SLC38A4 in retinoic acid receptors (RAR) expression cells (compare with counterpart RAR knockout cells)	adb	EP03553	.	.	.	Histone acetylation Retinoic acid receptors (RAR) expression cells	Histone acetylation	Histone_acetylation	Retinoic acid receptors (RAR) expression cells	.	Retinoic_acid_receptors_(RAR)_expression_cells	tissue	tissue	Promoter	.	H3K14	.	Increased SLC38A4 transcript levels was associated with decreased promoter CpG-island methylation and increased permissive histone modifications (H3K9/K14ac) in RAR knockout cells.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3439	.	.	.	.	.	.	.	.	.	.
DTD0028	SLC47A2	1	Hyperacetylation of SLC47A2 in renal cell carcinoma (compare with adjacent counterpart normal cells)	Hyperacetylation of SLC47A2 in renal cell carcinoma (compare with adjacent counterpart normal cells)	adb	EP09964	.	.	.	Histone acetylation Renal cell carcinoma	Histone acetylation	Histone_acetylation	Renal cell carcinoma	2C90	Renal_cell_carcinoma	tissue	tissue	Promoter	.	H3K27	.	H3K27AC might play a repressive role in the expression of SLC47A2 in RCC.	Chromatin immunoprecipitation	Patients samples of human	Down	RT-qPCR	.	.	.	.	.	ref3455	.	.	.	.	.	.	.	.	.	.
DTD0425	SLC5A5	1	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	adb	EP01976	.	.	.	Histone acetylation Thyroid cancer	Histone acetylation	Histone_acetylation	Thyroid cancer	2D10	Thyroid_cancer	tissue	tissue	Promoter	.	H3K9	.	Histone deacetylation occurred on all these lysine residues of histones at the SLC5A5 promoter upon the activation of MAPK by BRAF V600E.	Chromatin immunoprecipitation	Multiple cell lines of human and rat	Down	Western Blot	.	.	.	.	.	ref3447	.	.	.	.	.	.	.	.	.	.
DTD0425	SLC5A5	1	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	adb	EP01976	.	.	.	Histone acetylation Thyroid cancer	Histone acetylation	Histone_acetylation	Thyroid cancer	2D10	Thyroid_cancer	tissue	tissue	Promoter	.	H3K14	.	Histone deacetylation occurred on all these lysine residues of histones at the SLC5A5 promoter upon the activation of MAPK by BRAF V600E.	Chromatin immunoprecipitation	Multiple cell lines of human and rat	Down	Western Blot	.	.	.	.	.	ref3447	.	.	.	.	.	.	.	.	.	.
DTD0425	SLC5A5	1	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	adb	EP01976	.	.	.	Histone acetylation Thyroid cancer	Histone acetylation	Histone_acetylation	Thyroid cancer	2D10	Thyroid_cancer	tissue	tissue	Promoter	.	H3K18	.	Histone deacetylation occurred on all these lysine residues of histones at the SLC5A5 promoter upon the activation of MAPK by BRAF V600E.	Chromatin immunoprecipitation	Multiple cell lines of human and rat	Down	Western Blot	.	.	.	.	.	ref3447	.	.	.	.	.	.	.	.	.	.
DTD0425	SLC5A5	1	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	adb	EP01976	.	.	.	Histone acetylation Thyroid cancer	Histone acetylation	Histone_acetylation	Thyroid cancer	2D10	Thyroid_cancer	tissue	tissue	Promoter	.	H4K16	.	Histone deacetylation occurred on all these lysine residues of histones at the SLC5A5 promoter upon the activation of MAPK by BRAF V600E.	Chromatin immunoprecipitation	Multiple cell lines of human and rat	Down	Western Blot	.	.	.	.	.	ref3447	.	.	.	.	.	.	.	.	.	.
DTD0425	SLC5A5	1	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	adb	EP01976	.	.	.	Histone acetylation Thyroid cancer	Histone acetylation	Histone_acetylation	Thyroid cancer	2D10	Thyroid_cancer	tissue	tissue	Promoter	.	H3K9	.	The underlying mechanism of HDACi-induced upregulation of SLC5A5 gene expression via improving the acetylation status of histone at the promoter was elucidated directly by ChIP assay	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref3471	.	.	.	.	.	.	.	.	.	.
DTD0425	SLC5A5	1	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	adb	EP01976	.	.	.	Histone acetylation Thyroid cancer	Histone acetylation	Histone_acetylation	Thyroid cancer	2D10	Thyroid_cancer	tissue	tissue	Promoter	.	H3K14	.	The underlying mechanism of HDACi-induced upregulation of SLC5A5 gene expression via improving the acetylation status of histone at the promoter was elucidated directly by ChIP assay	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref3471	.	.	.	.	.	.	.	.	.	.
DTD0425	SLC5A5	1	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	Hypoacetylation of SLC5A5 in thyroid cancer (compare with counterpart healthy thyroid cells)	adb	EP01976	.	.	.	Histone acetylation Thyroid cancer	Histone acetylation	Histone_acetylation	Thyroid cancer	2D10	Thyroid_cancer	tissue	tissue	Promoter	.	H4K16	.	The underlying mechanism of HDACi-induced upregulation of SLC5A5 gene expression via improving the acetylation status of histone at the promoter was elucidated directly by ChIP assay	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref3471	.	.	.	.	.	.	.	.	.	.
DTD0425	SLC5A5	1	Hypoacetylation of SLC5A5 in breast cancer (compare with SAHA treatment counterpart cells)	Hypoacetylation of SLC5A5 in breast cancer (compare with SAHA treatment counterpart cells)	adb	EP01977	.	.	.	Histone acetylation Breast cancer	Histone acetylation	Histone_acetylation	Breast cancer	2C60-2C6Z	Breast_cancer	tissue	tissue	Promoter	.	H3	.	Levels of acetylated K9 and K14 were increased in high-responsive cells (MDA468) and reduced in low-responsive cells (MDA157). It is possible to hypothesize that decrease of H3 histone acetylation in low-responsive cells is not permissive for induction of high levels of NIS mRNA upon SAHA treatment.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref3448	.	.	.	.	.	.	.	.	.	.
DTD0452	SLC6A2	1	Hyperacetylation of SLC6A2 in corticotropin releasing factor (CRF) treatment neuroblastoma cells (compare with counterpart neuroblastoma cells)	Hyperacetylation of SLC6A2 in corticotropin releasing factor (CRF) treatment neuroblastoma cells (compare with counterpart neuroblastoma cells)	ad	EP10664	.	.	.	Histone acetylation Neuroblastoma cells treatment with CRF	Histone acetylation	Histone_acetylation	Neuroblastoma cells treatment with CRF	.	Neuroblastoma_cells_treatment_with_CRF	tissue	tissue	Promoter	.	H3	.	Chromatin immunoprecipitation assays confirm an increased acetylation of histone H3 on the NET promoter following treatment with CRF.	Chromatin immunoprecipitation	Multiple cell lines of human	Up	RT-qPCR	.	.	.	.	.	ref3731	.	.	.	.	.	.	.	.	.	.
DTD0455	Slc6a3	1	Hypoacetylation of Slc6a3 in rat dopaminergic cell (compare with valproate-treatment counterpart cells)	Hypoacetylation of Slc6a3 in rat dopaminergic cell (compare with valproate-treatment counterpart cells)	adb	EP01623	.	.	.	Histone acetylation Rat dopaminergic cell	Histone acetylation	Histone_acetylation	Rat dopaminergic cell	.	Rat_dopaminergic_cell	tissue	tissue	Promoter	.	H3K9	.	Valproate treatment results in enhanced histone acetylation at the Slc6a3 promoter in cultured rat N27 cells.	Chromatin immunoprecipitation	Rat dopaminergic cell line (N27) 	Down	RT-qPCR	.	.	.	.	.	ref3461	.	.	.	.	.	.	.	.	.	.
DTD0455	Slc6a3	1	Hypoacetylation of Slc6a3 in rat dopaminergic cell (compare with valproate-treatment counterpart cells)	Hypoacetylation of Slc6a3 in rat dopaminergic cell (compare with valproate-treatment counterpart cells)	adb	EP01623	.	.	.	Histone acetylation Rat dopaminergic cell	Histone acetylation	Histone_acetylation	Rat dopaminergic cell	.	Rat_dopaminergic_cell	tissue	tissue	Promoter	.	H3K14	.	Valproate treatment results in enhanced histone acetylation at the Slc6a3 promoter in cultured rat N27 cells.	Chromatin immunoprecipitation	Rat dopaminergic cell line (N27) 	Down	RT-qPCR	.	.	.	.	.	ref3461	.	.	.	.	.	.	.	.	.	.
DTD0456	SLC6A4	1	Hypoacetylation of SLC6A4 in several types of cancer (compare with trichostatin A treatment counterpart cells)	Hypoacetylation of SLC6A4 in several types of cancer (compare with trichostatin A treatment counterpart cells)	adb	EP01605	.	.	.	Histone acetylation Several types of cancer	Histone acetylation	Histone_acetylation	Several types of cancer	2A00-2F9Z	Several_types_of_cancer	tissue	tissue	Promoter	.	H4	.	SLC6A4 gene is epigenetically downregulated by HDAC1 in several types of cancer.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	Western Blot	.	.	.	.	.	ref3451	.	.	.	.	.	.	.	.	.	.
DTD0456	SLC6A4	1	Hypoacetylation of SLC6A4 in epithelial colorectal adenocarcinoma (compare with butyrate-treatment counterpart cells)	Hypoacetylation of SLC6A4 in epithelial colorectal adenocarcinoma (compare with butyrate-treatment counterpart cells)	adb	EP01606	.	.	.	Histone acetylation Epithelial colorectal adenocarcinoma	Histone acetylation	Histone_acetylation	Colorectal cancer	2B91	Epithelial_colorectal_adenocarcinoma	tissue	tissue	Promoter	.	H3	.	The SLC6A4 promoter 1 region appears to be specifically modulated by alterations in the acetylation (but not methylation) status of histone H3.	Chromatin immunoprecipitation	Human epithelial colorectal adenocarcinoma cells (Caco-2) 	Down	Western Blot	.	.	.	.	.	ref3443	.	.	.	.	.	.	.	.	.	.
DTD0456	SLC6A4	1	Hypoacetylation of SLC6A4 in epithelial colorectal adenocarcinoma (compare with butyrate-treatment counterpart cells)	Hypoacetylation of SLC6A4 in epithelial colorectal adenocarcinoma (compare with butyrate-treatment counterpart cells)	adb	EP01606	.	.	.	Histone acetylation Epithelial colorectal adenocarcinoma	Histone acetylation	Histone_acetylation	Colorectal cancer	2B91	Epithelial_colorectal_adenocarcinoma	tissue	tissue	Promoter	.	H4	.	The SLC6A4 promoter 1 region appears to be specifically modulated by alterations in the acetylation (but not methylation) status of histone H4.	Chromatin immunoprecipitation	Human epithelial colorectal adenocarcinoma cells (Caco-2) 	Down	Western Blot	.	.	.	.	.	ref3443	.	.	.	.	.	.	.	.	.	.
DTD0456	SLC6A4	1	Hypoacetylation of SLC6A4 in neuroblastoma cells (compare with TSA-treatment counterpart cells)	Hypoacetylation of SLC6A4 in neuroblastoma cells (compare with TSA-treatment counterpart cells)	adf	EP10666	.	.	.	Histone acetylation Neuroblastoma cells	Histone acetylation	Histone_acetylation	Neuroblastoma cells	.	Neuroblastoma_cells	tissue	tissue	.	.	.	.	Dramatic upregulation of dopamine and serotonin transporter expression by inhibition of histone deacetylases.	Chromatin immunoprecipitation	Human neuroblastoma cell line (SK-NF-I)	Down	Western Blot	.	.	.	.	.	ref3732	.	.	.	.	.	.	.	.	.	.
DTD0021	SLC15A1	1	Hypoacetylation of SLC15A1 in Colorectal cancer	Hypoacetylation of SLC15A1 in Colorectal cancer	ag	EP38517	.	.	.	Histone deacetylation Colorectal cancer	Histone deacetylation	Histone_deacetylation	Colorectal cancer	2B90	Colorectal_cancer	tissue	tissue	Promoter (distal)	.	H3K18;H3K27	.	"HDAC1-mediated histone deacetylation blocks P300-mediated H3K18/27Ac at the distal promoter, contributing to PEPT1 silencing."	.	"CRC cell lines, xenografts"	Down	"ChIP-qPCR,reporter assays,siRNA knockdown"	.	.	.	.	.	ref13334	.	.	.	.	.	.	.	.	.	.
DTD0083	Slc12a2	1	Lower level of histone dimethylation of Slc12a2 in hypertension (compare with normal rats)	Lower level of histone dimethylation of Slc12a2 in hypertension (compare with normal rats)	ada	EP09080	.	.	.	Histone dimethylation Hypertension	Histone dimethylation	Histone_dimethylation	Hypertension	BA00-BA04	Hypertension	tissue	tissue	Promoter	.	H3K9	.	The decreased levels of mRNA expression correlated with increment of dimethylation on H3K4 at the Slc12a2 promoter region in spontaneously hypertensive rat.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3438	.	.	.	.	.	.	.	.	.	.
DTD0083	Slc12a2	1	Higher level of histone dimethylation of Slc12a2 in hypertension (compare with normal rats)	Higher level of histone dimethylation of Slc12a2 in hypertension (compare with normal rats)	ada	EP09084	.	.	.	Histone dimethylation Hypertension	Histone dimethylation	Histone_dimethylation	Hypertension	BA00-BA04	Hypertension	tissue	tissue	Promoter	.	H3K4	.	The increased levels of mRNA expression correlated with increment of dimethylation on H3K4 at the Slc12a2 promoter region in spontaneously hypertensive rat.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Up	RT-qPCR	.	.	.	.	.	ref3438	.	.	.	.	.	.	.	.	.	.
DTD0257	SLC2A2	1	Higher level of histone dimethylation of SLC2A2 in type 2 diabetes (compare with counterpart normal rat cells)	Higher level of histone dimethylation of SLC2A2 in type 2 diabetes (compare with counterpart normal rat cells)	adc	EP05269	.	.	.	Histone dimethylation Type 2 diabetes	Histone dimethylation	Histone_dimethylation	Type 2 diabetes	5A11	Type_2_diabetes	tissue	tissue	Promoter	.	H3K9	.	Increased H3K9me2 levels basically was correlated with decreased Glut2 gene expression.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	RT-qPCR	.	.	.	.	.	ref3449	.	.	.	.	.	.	.	.	.	.
DTD0014	ABCB11	1	Histone methylation of ABCB11 in Hepatocellular carcinoma	Histone methylation of ABCB11 in Hepatocellular carcinoma	ag	EP38514	.	.	.	Histone methylation Hepatocellular carcinoma	Histone methylation	Histone_methylation	Hepatocellular carcinoma	2C12	Hepatocellular_carcinoma	tissue	tissue	Promoter	.	H3K27;H3K9	.	"Alcohol exposure upregulates histone methyltransferases (RBBP-5/Suv39h1/ASH2L/SET7/9) and downregulates demethylases (JARID1a/b/c), leading to BSEP suppression. Altered BA homeostasis promotes HCC progression."	.	Ethanol-treated mice & HCC cells	Down	.	.	.	.	.	.	ref8661	.	.	.	.	.	.	.	.	.	.
DTD0014	ABCB11	1	Histone methylation of ABCB11 in Cholestasis	Histone methylation of ABCB11 in Cholestasis	ag	EP38515	.	.	.	Histone methylation Cholestasis	Histone methylation	Histone_methylation	Cholestasis	5C50.1	Cholestasis	tissue	tissue	Promoter	.	H3K4	.	MLL3 (as part of ASCOM complex) mediates H3K4me3 for FXR/GR-dependent activation of BSEP. Downregulated in cholestasis leading to reduced BSEP expression.	.	CBDL mice & HepG2 cells	Down	RT-qPCR	.	.	.	.	.	ref13332	.	.	.	.	.	.	.	.	.	.
DTD0257	SLC2A2	1	Higher level of histone monomethylation of SLC2A2 in type 2 diabetes (compare with counterpart normal rat cells)	Higher level of histone monomethylation of SLC2A2 in type 2 diabetes (compare with counterpart normal rat cells)	add	EP05268	.	.	.	Histone monomethylation Type 2 diabetes	Histone monomethylation	Histone_monomethylation	Type 2 diabetes	5A11	Type_2_diabetes	tissue	tissue	Promoter	.	H3K9	.	Increased H3K4me levels basically was correlated with decreased Glut2 gene expression.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	RT-qPCR	.	.	.	.	.	ref3449	.	.	.	.	.	.	.	.	.	.
DTD0083	Slc12a2	1	Hypoacetylation of Slc12a2 in hypertension (compare with Ang II-treatment counterpart hypertension rats)	Hypoacetylation of Slc12a2 in hypertension (compare with Ang II-treatment counterpart hypertension rats)	ade	EP09082	.	.	.	Histone trimethylation Hypertension	Histone trimethylation	Histone_trimethylation	Hypertension	BA00-BA04	Hypertension	tissue	tissue	Promoter	.	H3K4	.	Slc12a2 is upregulated via histone modification in the aortas of Ang II-induced hypertensive SD rats.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	RT-qPCR	.	.	.	.	.	ref3441	.	.	.	.	.	.	.	.	.	.
DTD0158	SLC23A1	1	Lower level of histone trimethylation of SLC23A1 in colon (compare with jejunum tissue of human)	Lower level of histone trimethylation of SLC23A1 in colon (compare with jejunum tissue of human)	ade	EP07374	.	.	.	Histone trimethylation Colon	Histone trimethylation	Histone_trimethylation	Colon	.	Colon	tissue	tissue	Promoter	.	H3K4	.	Lower levels of H3 trimethylation of lysine 4 and lower gene expression was observed in the SLC23A1 promoter in the colon.	Chromatin immunoprecipitation	Patients samples of human	Down	RT-qPCR	.	.	.	.	.	ref3456	.	.	.	.	.	.	.	.	.	.
DTD0159	SLC23A2	1	Lower level of histone trimethylation of SLC23A2 in colon (compare with jejunum tissue of human)	Lower level of histone trimethylation of SLC23A2 in colon (compare with jejunum tissue of human)	ade	EP07340	.	.	.	Histone trimethylation Colon	Histone trimethylation	Histone_trimethylation	Colon	.	Colon	tissue	tissue	Promoter	.	H3K4	.	Lower levels of H3 trimethylation of lysine 4 and lower gene expression was observed in the SLC23A2 promoter in the colon.	Chromatin immunoprecipitation	Patients samples of human	Down	RT-qPCR	.	.	.	.	.	ref3456	.	.	.	.	.	.	.	.	.	.
DTD0159	SLC23A2	1	Lower level of histone trimethylation of SLC23A2 in chronic alcohol exposure (compare with counterpart normal pancreatic acinar rat cells)	Lower level of histone trimethylation of SLC23A2 in chronic alcohol exposure (compare with counterpart normal pancreatic acinar rat cells)	ade	EP07341	.	.	.	Histone trimethylation Chronic alcohol exposure	Histone trimethylation	Histone_trimethylation	Chronic alcohol exposure	6C40.2Z	Chronic_alcohol_exposure	tissue	tissue	Promoter	.	H3K4	.	Chronic exposure of mouse pancreatic acinar tumor cells to alcohol is associated with a significant reduction in the level of expression of H3K4me3 (an activation mark) of the Slc23a2.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3453	.	.	.	.	.	.	.	.	.	.
DTD0159	SLC23A2	1	Higher level of histone trimethylation of SLC23A2 in chronic alcohol exposure (compare with counterpart normal pancreatic acinar rat cells)	Higher level of histone trimethylation of SLC23A2 in chronic alcohol exposure (compare with counterpart normal pancreatic acinar rat cells)	ade	EP07344	.	.	.	Histone trimethylation Chronic alcohol exposure	Histone trimethylation	Histone_trimethylation	Chronic alcohol exposure	6C40.2Z	Chronic_alcohol_exposure	tissue	tissue	Promoter	.	H3K27	.	Chronic exposure of mouse pancreatic acinar tumor cells to alcohol is associated with a significant increase in the level of the H3K27me3 (a repressive mark) of the Slc23a2.	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3453	.	.	.	.	.	.	.	.	.	.
DTD0184	SLC25A23	1	Lower level of histone trimethylation of SLC25A23 in astrocytic tumors (compare with normal counterpart cells)	Lower level of histone trimethylation of SLC25A23 in astrocytic tumors (compare with normal counterpart cells)	adf	EP06742	.	.	.	Histone trimethylation Astrocytic tumors	Histone trimethylation	Histone_trimethylation	Astrocytic tumors	2A00.0Y	Astrocytic_tumors	tissue	tissue	.	.	H3K27	.	There is a direct role of H3K27me3 modification in epigenetically silencing the SLC25A23 gene expression.	Chromatin immunoprecipitation	Patients samples of human	Down	Western Blot	.	.	.	.	.	ref3458	.	.	.	.	.	.	.	.	.	.
DTD0230	SLC26A2	1	Lower level of histone trimethylation of SLC26A2 in colon cancer (compare with normal counterpart cells)	Lower level of histone trimethylation of SLC26A2 in colon cancer (compare with normal counterpart cells)	ade	EP06118	.	.	.	Histone trimethylation Colon cancer	Histone trimethylation	Histone_trimethylation	Colon cancer	2B90	Colon_cancer	tissue	tissue	Promoter	.	H3K4	.	"Loss of H3 lysine 4 methylation was observed in cultured colon cancer cells with diminished SLC26A2 transcription, such as SW480, SW1083, and HT29."	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3437	.	.	.	.	.	.	.	.	.	.
DTD0251	SLC2A1	1	Lower level of histone trimethylation of SLC2A1 in colon cancer (compare with counterpart JMJD2B knockdown cells)	Lower level of histone trimethylation of SLC2A1 in colon cancer (compare with counterpart JMJD2B knockdown cells)	ade	EP05465	.	.	.	Histone trimethylation Colon cancer	Histone trimethylation	Histone_trimethylation	Colon cancer	2B90	Colon_cancer	tissue	tissue	Promoter	.	H3K9	.	Knockdown of JMJD2B after glucose deprivation caused decreased level of GLUT1 through increasing H3K9 tri-methylation levels on its promoter.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3463	.	.	.	.	.	.	.	.	.	.
DTD0262	SLC2A4	1	Lower level of histone trimethylation of SLC2A4 in type 2 diabete (compare with counterpart normal rat cells)	Lower level of histone trimethylation of SLC2A4 in type 2 diabete (compare with counterpart normal rat cells)	ade	EP05187	.	.	.	Histone trimethylation Type 2 diabetes	Histone trimethylation	Histone_trimethylation	Type 2 diabetes	5A11	Type_2_diabetes	tissue	tissue	Promoter	.	H3K9	.	"The Type 2 diabetes reduced the H3Kac and increased the H3K9me3 content, and insulin treatment reversed only the H3K9me3 modification."	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3469	.	.	.	.	.	.	.	.	.	.
DTD0262	SLC2A4	1	Higher level of histone trimethylation of SLC2A4 in type 1 diabete (compare with counterpart normal rat cells)	Higher level of histone trimethylation of SLC2A4 in type 1 diabete (compare with counterpart normal rat cells)	ade	EP05192	.	.	.	Histone trimethylation Type 1 diabetes	Histone trimethylation	Histone_trimethylation	Type 1 diabetes	5A10	Type_1_diabetes	tissue	tissue	Promoter	.	H3K9	.	"The Type 1 diabetes reduced the H3Kac and increased the H3K9me3 content, and insulin treatment reversed only the H3K9me3 modification."	Chromatin immunoprecipitation	Model organism in vivo (mouse)	Down	Western Blot	.	.	.	.	.	ref3469	.	.	.	.	.	.	.	.	.	.
DTD0331	SLC38A4	1	Lower level of histone trimethylation of SLC38A4 in retinoic acid receptors (RAR) expression cells (compare with counterpart RAR knockout cells)	Lower level of histone trimethylation of SLC38A4 in retinoic acid receptors (RAR) expression cells (compare with counterpart RAR knockout cells)	ade	EP03552	.	.	.	Histone trimethylation Retinoic acid receptors (RAR) expression cells	Histone trimethylation	Histone_trimethylation	Retinoic acid receptors (RAR) expression cells	.	Retinoic_acid_receptors_(RAR)_expression_cells	tissue	tissue	Promoter	.	H3K4	.	Increased SLC38A4 transcript levels was associated with decreased promoter CpG-island methylation and increased permissive histone modifications (H3K4me3) in RAR knockout cells.	Chromatin immunoprecipitation	Multiple cell lines of human	Down	RT-qPCR	.	.	.	.	.	ref3439	.	.	.	.	.	.	.	.	.	.
DTD0028	SLC47A2	1	Lower level of histone trimethylation of SLC47A2 in renal cell carcinoma (compare with adjacent counterpart normal cells)	Lower level of histone trimethylation of SLC47A2 in renal cell carcinoma (compare with adjacent counterpart normal cells)	ade	EP09962	.	.	.	Histone trimethylation Renal cell carcinoma	Histone trimethylation	Histone_trimethylation	Renal cell carcinoma	2C90	Renal_cell_carcinoma	tissue	tissue	Promoter	.	H3K27	.	H3K27me3 might play a repressive role in the expression of SLC47A2 in RCC.	Chromatin immunoprecipitation	Patients samples of human	Down	RT-qPCR	.	.	.	.	.	ref3455	.	.	.	.	.	.	.	.	.	.
DTD0028	SLC47A2	1	Lower level of histone trimethylation of SLC47A2 in renal cell carcinoma (compare with adjacent counterpart normal cells)	Lower level of histone trimethylation of SLC47A2 in renal cell carcinoma (compare with adjacent counterpart normal cells)	ade	EP09962	.	.	.	Histone trimethylation Renal cell carcinoma	Histone trimethylation	Histone_trimethylation	Renal cell carcinoma	2C90	Renal_cell_carcinoma	tissue	tissue	Promoter	.	H3K4	.	H3K4me3 might play a repressive role in the expression of SLC47A2 in RCC.	Chromatin immunoprecipitation	Patients samples of human	Down	RT-qPCR	.	.	.	.	.	ref3455	.	.	.	.	.	.	.	.	.	.