Drug Transporter (DT) Information

General Information of DT
DT ID DTD0347
Gene Name SLC39A6
Protein Name Zinc transporter ZIP6
Gene ID
25800
UniProt ID
Q13433
TCDB ID
2.A.5.4.13
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms Estrogen-regulated protein LIV-1; LIV-1; LIV1; SLC39A6; Solute carrier family 39 member 6; ZIP-6; ZIP6; Zinc transporter ZIP6
DT Family Zinc (Zn(2+))-Iron (Fe(2+)) Permease (ZIP) Family ;
Tissue Specificity Highly expressed in the breast, prostate,placenta, kidney, pituitary and corpus callosum. Weakly expressedin heart and intestine. Also highly expressed in cells derivedfrom an adenocarcinoma of the cervix and lung carcinoma.
Function This transporter may act as a zinc-influx transporter.
Endogenous Substrate(s) Zn2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Zinc transporter ZIP6
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Zinc transporter ZIP6
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Zinc transporter ZIP6
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Zinc transporter ZIP6
Microbiota Influence (MBI)

(β) Post-translational Modification of Zinc transporter ZIP6
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Zinc transporter ZIP6
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Zinc transporter ZIP6
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Zinc transporter ZIP6
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Zinc transporter ZIP6
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Zinc transporter ZIP6
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Zinc salts
 Preclinical Drug Info Arthritis FA5Z [1]
References
1 A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313.

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