Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0347 Transporter Info
Gene Name	SLC39A6
Transporter Name	Zinc transporter ZIP6
Gene ID	25800
UniProt ID	Q13433

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A6 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC39A6 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Valproic Acid results in increased expression of SLC39A6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A6 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A6 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC39A6 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC39A6 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	afimoxifene results in decreased expression of SLC39A6 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
apicidin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	apicidin results in increased expression of SLC39A6 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
Asbestos, Serpentine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Serpentine results in increased expression of SLC39A6 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in increased expression of SLC39A6 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC39A6 gene		[26]
Regulation Mechanism			Transcription Factor Info
chromium hexavalent ion	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in increased expression of SLC39A6 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in decreased expression of SLC39A6 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A6 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A6 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of SLC39A6 protein		[28]
Regulation Mechanism			Transcription Factor Info
gallium nitrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	gallium nitrate results in decreased expression of SLC39A6 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
geldanamycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	geldanamycin results in increased expression of SLC39A6 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC39A6 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC39A6 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
Nicotine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nicotine results in increased expression of SLC39A6 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	10 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2L1 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased cleavage of CASP3 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased expression of BAX protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form results in decreased susceptibility to trichostatin A		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2L1 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased cleavage of CASP3 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased expression of BAX protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form results in decreased susceptibility to trichostatin A		[23]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC39A6 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC39A6 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC39A6 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
trichostatin A	19 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2L1 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased cleavage of CASP3 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased expression of BAX protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form results in decreased susceptibility to trichostatin A		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A6 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2L1 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	SLC39A6 mutant form inhibits the reaction trichostatin A results in increased cleavage of CASP3 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	SLC39A6 mutant form inhibits the reaction trichostatin A results in increased expression of BAX protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	SLC39A6 mutant form results in decreased susceptibility to trichostatin A		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	trichostatin A results in decreased expression of SLC39A6 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	trichostatin A results in increased expression of SLC39A6 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	trichostatin A results in increased expression of SLC39A6 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2L1 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation16	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation17	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased cleavage of CASP3 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation18	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased expression of BAX protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation19	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form results in decreased susceptibility to trichostatin A		[23]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC39A6 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC39A6 mutant form results in decreased susceptibility to Vorinostat		[23]
Regulation Mechanism			Transcription Factor Info
Zinc	8 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC39A6 protein affects the uptake of Zinc		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC39A6 protein results in increased transport of Zinc		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	SLC39A6 protein results in increased uptake of Zinc		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2L1 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in decreased expression of BCL2 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased cleavage of CASP3 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form inhibits the reaction trichostatin A results in increased expression of BAX protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Zinc inhibits the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction SLC39A6 mutant form results in decreased susceptibility to trichostatin A		[23]
Regulation Mechanism			Transcription Factor Info
zinc chromate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in increased expression of SLC39A6 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC39A6		[1]
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fulvestrant inhibits the expression of SLC39A6		[1]
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride inhibits the expression of SLC39A6		[1]
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nicotine polacrilex increases the expression of SLC39A6		[2]
Gallium nitrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gallium nitrate inhibits the expression of SLC39A6		[3]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of SLC39A6		[4]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the expression of SLC39A6		[5]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC39A6		[6]
Panobinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Panobinostat inhibits the expression of SLC39A6		[7]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC39A6		[8]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC39A6		[9]
Valproic Acid	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC39A6		[7]
Drug in Phase 3 Trial
Afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Afimoxifene inhibits the expression of SLC39A6		[1]
torcetrapib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	torcetrapib increases the expression of SLC39A6		[11]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC39A6		[12]
Drug in Phase 1 Trial
Geldanamycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Geldanamycin increases the expression of SLC39A6		[13]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A inhibits the expression of SLC39A6		[7]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC39A6		[19]
Plant Extract
Grape Seed Proanthocyanidins	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Grape Seed Proanthocyanidins increases the expression of SLC39A6		[10]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC39A6		[14]
DT Modulation2	Aflatoxin B1 affects the expression of SLC39A6 protein		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of SLC39A6 gene		[14]
Regulation Mechanism			Transcription Factor Info
ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ochratoxin A results in decreased expression of SLC39A6 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in increased expression of SLC39A6 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ochratoxin A inhibits the expression of SLC39A6		[16]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide increases the expression of SLC39A6		[18]
Carcinogen
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC39A6		[17]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC39A6 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos inhibits the expression of SLC39A6		[15]

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Detail Information of Exogenous Modulation

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