Drug Transporter (DT) Information

General Information of DT
DT ID DTD0083
Gene Name SLC12A2
Protein Name Basolateral Na-K-Cl symporter
Gene ID
6558
UniProt ID
P55011
TCDB ID
2.A.30.1.4
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6PZT_A

Identity:99.571%

Minimized Score:-1143.484 kcal/mol

Detail: Structure Info

Synonyms Basolateral Na-K-Cl symporter; Solute carrier family 12 member 2; SLC12A2; NKCC1
DT Family Cation-Chloride Cotransporter (CCC) Family ;
Tissue Specificity Expressed in many tissues.
Function This transporter mediates sodium and chloride reabsorption, and plays a vital role in the regulation of ionic balance and cell volume.
Disease(s) Severe mood disorders [ICD-11:6A8Z]
Endogenous Substrate(s) Sodium; Chloride
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Basolateral Na-K-Cl symporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Basolateral Na-K-Cl symporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Basolateral Na-K-Cl symporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Basolateral Na-K-Cl symporter
Microbiota Influence (MBI)

(β) Post-translational Modification of Basolateral Na-K-Cl symporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Basolateral Na-K-Cl symporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Basolateral Na-K-Cl symporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Basolateral Na-K-Cl symporter
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Basolateral Na-K-Cl symporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Basolateral Na-K-Cl symporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Potassium chloride
 Approved Drug Info Hypokalemia 5C77 [1]
Sodium chloride
 Approved Drug Info Severe mood disorders 6A8Z [1]
References
1 Expression of the sodium potassium chloride cotransporter (NKCC1) and sodium chloride cotransporter (NCC) and their effects on rat lens transparency. Mol Vis. 2010 May 4;16:800-12.

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