Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0083 Transporter Info
Gene Name SLC12A2
Transporter Name Basolateral Na-K-Cl symporter
Gene ID
6558
UniProt ID
P55011

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A2 gene in coronary artery disease condition [1]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC12A2 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A2 gene in coronary artery disease condition [1]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC12A2 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [2]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        BHLHE40 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [3]

TF Protein Name

 Class E basic helix-loop-helix protein 40 Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [4]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Tissue

 Myotube

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myoblast determination protein 1 (MYOD1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        TCF12 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [5]

TF Protein Name

 Transcription factor 12 Transcription Factor Info

Tissue

 Blood; Brain; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor 12 (TCF12) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [2]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A2 gene in glioblastoma multiforme condition [6]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC12A2 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A2 gene in gastric cancer condition [7]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Affected Drug/Substrate

 Metformin

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC12A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 10 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [5]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        CTCFL 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [5]

TF Protein Name

 Transcriptional repressor CTCFL Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A2 gene in erythroleukemia condition [8]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC12A2 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [2]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [2]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Embryo; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [4]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        SALL4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A2 gene in health condition [9]

TF Protein Name

 Sal-like protein 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Sal-like protein 4 (SALL4) has been reported to bind to the transcription of SLC12A2 gene in health condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A2 gene in podocyte condition [10]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC12A2 gene in podocyte condition, which leads to an increased expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [3]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [4]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        CDX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene in health condition [11]

TF Protein Name

 Homeobox protein CDX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein CDX-2 (CDX2) has been reported to bind to the transcription of SLC12A2 gene in health condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        HOXB13 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [2]

TF Protein Name

 Homeobox protein Hox-B13 Transcription Factor Info

Tissue

 Colon; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Homeobox protein Hox-B13 (HOXB13) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        ZEB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [2]

TF Protein Name

 Zinc finger E-box-binding homeobox 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [4]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [3]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Bone marrow; Cervix; Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [4]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [3]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Embryo; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [5]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [2]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [4]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [5]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [3]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [5]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

        SPI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A2 gene in APL condition [12]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC12A2 gene in acute promyelocytic leukemia (APL) condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

       Transcriptional Phenomenon2

 Direct binding to SLC12A2 gene [3]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [4]

TF Protein Name

 Lysine-specific demethylase 5B Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A2 gene in colorectal cancer condition [13]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC12A2 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

TF Superclass5: alpha-Helices exposed by beta-structures

      Class5.1: MADS box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SRF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A2 gene [5]

TF Protein Name

 Serum response factor Transcription Factor Info

Tissue

 Embryo; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Serum response factor (SRF) can directly bind to the SLC12A2 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP53 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A2 gene in HFKS condition [14]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC12A2 gene in HFKS condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

       Transcriptional Phenomenon2

 Binding to SLC12A2 gene in health condition [15]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC12A2 gene in health condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A2 gene in epithelial ovarian cancer condition [16]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC12A2 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.
References
1 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-152. (ID:ENSG00000064651)
6 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
7 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
8 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
9 SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
10 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
11 Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2). J Biol Chem. 2010;285(33):25115-25.
12 Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
13 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
14 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
15 Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle. 2011;10(24):4237-49.
16 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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