Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00184
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| Drug Name |
Potassium chloride
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| Synonyms |
11118_FLUKA; Acronitol; Addi-K; Apo-K; Celeka; Cena-K; Chlorid draselny; Chlorid draselny [Czech]; Chloride of potash; Chloride, Potassium; Chloropotassuril; Chloropotassuril diffu-K; Chlorvescent; Clor-K-Zaf; Conductance standard solution; Conductivity Standard Solution, 1413-S/cm; Conductivity Standard Solution, 500-S/cm; Diffu-K; Dipotassium dichloride; Duffi-K; Durekal; Durules; Durules-K; Emplets potassium chloride; Enpott; Enseal; Hydrochloric acid potassium salt (1:1); IN2900; ISA (ionic strength adjustment solution: 1 M KCl); Infalyte; K Tab; K+10; K+8; K-10; K-Care; K-Contin; K-Dur; K-Grad; K-Lease; K-Lor; K-Lyte Cl; K-Lyte/Cl; K-Norm; K-Predne-Dome; K-SR; K-Sol; K-Tab; K-dur (TN); K-lyte/C1; K. tab; KCL; KCL (TN); KCL Retard; KCl-retard Zyma; KM potassium chloride; KSR; Kadalex; Kalcorid; Kaleorid; Kaleorod; Kaliduron; Kaliglutol; Kalilente; Kalinor-Retard P; Kalinorm; Kalinorm Depottab; Kaliolite; Kalipor; Kalipoz; Kalitabs; Kalitrans Retard; Kalium Duriles; Kalium Durules; Kalium Retard; Kalium S.R; Kalium S.R.; Kalium SR; Kalium-Durettes; Kalium-R; Kalium-duriles; Kaliumchlorid; Kaochlor; Kaon Cl; Kaon Cl-10; Kaon Ultra; Kaon-Cl; Kaon-Cl (TN); Kaon-Cl 10; Kaon-Cl TABS; Kaon-ci; Kaskay; Kato; Kay Ciel; Kay-Cee-L; Kay-Ciel; Kay-EM; Kayback; Kayciel; Kaysiel; Kelp salt; Keylyte; Klor-Con; Klor-Con M10; Klor-Con M15; Klor-Con M20; Klor-Lyte; Klor-con (TN); Kloren; Klorvess; Klotrix; Klotrix (TN); Kolyum; Lento-K; Lento-Kalium; Leo K; Leo-K; Micro-K; Micro-K 10; Micro-K Extentcaps; Micro-K LS; Micro-Kalium Retard; Miopotasio; Monopotassium chloride; Muriate of potash; Natural sylvite; Neobakasal; Nu-K; POTASSIUM CHLORIDE, ACS; POTASSIUM CHLORIDE, U.S.P.; Peter-kal; Pfiklor; Plus Kalium Retard; Potasion; Potasol; Potassium Chloride 10meq in Plastic Container; Potassium Chloride BP; Potassium Chloride in Plastic Container; Potassium Cl; Potassium atomic spectroscopy standard concentrate 1.00 g K; Potassium chloride (JP15/USP); Potassium chloride (K3Cl3); Potassium chloride (KCl); Potassium chloride 20meq inplastic container; Potassium chloride 30meq in plastic container; Potassium chloride 40meq in plastic container; Potassium chloride [JAN]; Potassium chloride solution; Potassium chloride standard; Potassium monochloride; Potassium muriate; Potassium standard concentrate 10.00 g K; Potassium thallium chloride (KTlCl); Potavescent; Rekawan; Rekawan Retard; Repone K; Repone-K; Rum-K; Sal digestnum sylvii; Sando-K; Selora; Slow-K; Slow-K tablets; Span-K; Steropotassium; Super K; Super K (salt); Sylvite; Ten-K; Tripotassium trichloride; Trona muriate of potash; Trona potassium chloride; Ultra K Chlor; Ultra-K-Chlor; [KCl]
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| Drug Type |
Small molecular drug
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| Indication | Hypokalemia [ICD11:5C77] | Approved | [1] | |||
| Therapeutic Class |
Dietary supplement
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
ClK
|
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| Canonical SMILES |
[Cl-].[K+]
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| InChI |
InChI=1S/ClH.K/h1H;/q;+1/p-1
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| InChIKey |
WCUXLLCKKVVCTQ-UHFFFAOYSA-M
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| CAS Number |
CAS 7447-40-7
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| Pharmaceutical Properties | Molecular Weight | 74.55 | Topological Polar Surface Area | 0 | ||
| Heavy Atom Count | 2 | Rotatable Bond Count | 0 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 1 | |||
| PubChem CID | ||||||
| PubChem SID |
10318920
,10534589
,11528333
,118218
,15296892
,24845368
,24845466
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,24845849
,24847015
,24847722
,24852090
,24858895
,24859155
,24860713
,24860847
,24865635
,24868525
,24868598
,24874855
,24881076
,24881793
,24881794
,24881795
,24881796
,24881797
,24881798
,24881799
,24881800
,24881801
,24881802
,24898470
,24898546
,24898635
,24898905
,24899026
,24899027
,24899042
,29223954
,46506038
,48414359
,48420072
,48423984
,53790740
,5616990
,56312095
,56312742
,56312789
,7849122
,8152993
|
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| ChEBI ID |
ChEBI:32588
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | KCC1 | Transporter Info | Electroneutral potassium-chloride cotransporter 1 | Substrate | [2] | |
| KCC2 | Transporter Info | Electroneutral potassium-chloride cotransporter 2 | Substrate | [3] | ||
| KCC3 | Transporter Info | Electroneutral potassium-chloride cotransporter 3 | Substrate | [4] | ||
| NKCC1 | Transporter Info | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 | Substrate | [5] | ||
| NKCC2 | Transporter Info | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 | Substrate | [6] | ||
| OCTN2 | Transporter Info | Organic cation/carnitine transporter 2 | Substrate | [7] | ||
| References | ||||||
| 1 | Torsemide was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element. Blood. 2004 Jun 1;103(11):4302-9. | |||||
| 3 | Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol Cell Neurosci. 2010 Oct;45(2):173-9. | |||||
| 4 | Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site. Neuropsychopharmacology. 2009 Jan;34(2):458-67. | |||||
| 5 | Expression of the sodium potassium chloride cotransporter (NKCC1) and sodium chloride cotransporter (NCC) and their effects on rat lens transparency. Mol Vis. 2010 May 4;16:800-12. | |||||
| 6 | Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function. Curr Opin Nephrol Hypertens. 2014 Jan;23(1):1-8. | |||||
| 7 | Mutations affecting GABAergic signaling in seizures and epilepsy. Pflugers Arch. 2010 Jul;460(2):505-23. | |||||
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