Drug Transporter (DT) Information

General Information of DT
DT ID DTD0086
Gene Name SLC12A5
Protein Name Electroneutral potassium-chloride cotransporter 2
Gene ID
57468
UniProt ID
Q9H2X9
TCDB ID
2.A.30.1.18
3D Structure

Modelled DT Structure

Method:loop building

Template PDB:6M23_A

Identity:97.956%

Minimized Score:-2242.996 kcal/mol

Detail: Structure Info

Synonyms hKCC2; Neuronal K-Cl cotransporter; K-Cl cotransporter 2; KCC2; KIAA1176; Solute carrier family 12 member 5
DT Family Cation-Chloride Cotransporter (CCC) Family ;
Tissue Specificity Brain specific. Detected in neuronal cells.
Function This transporter mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition.
Endogenous Substrate(s) Chloride
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Electroneutral potassium-chloride cotransporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Electroneutral potassium-chloride cotransporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Electroneutral potassium-chloride cotransporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Electroneutral potassium-chloride cotransporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Electroneutral potassium-chloride cotransporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Electroneutral potassium-chloride cotransporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Electroneutral potassium-chloride cotransporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Electroneutral potassium-chloride cotransporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Electroneutral potassium-chloride cotransporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Potassium chloride
 Approved Drug Info Hypokalemia 5C77 [1]
References
1 Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol Cell Neurosci. 2010 Oct;45(2):173-9.

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