General Information of Drug Transporter (DT)
DT ID	DTD0086 Transporter Info
Gene Name	SLC12A5
Transporter Name	Electroneutral potassium-chloride cotransporter 2
Gene ID	57468
UniProt ID	Q9H2X9
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Loop building
Template PDB	6M23_A		Identity	97.956%
Performance	Minimized Score	-2242.996 kcal/mol
	Ramachandra Favored	Poor
	QMEANBrane Quality	Medium
Ramachandran Plot
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	Ramz Z Score	-1.51 ±0.24
	Residues in Favored Region	993	Ramachandran favored	94.30%
	Number of Outliers	10	Ramachandran outliers	0.95%
Local Quality
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	QMEANBrane Score		0.77
AlphaFold Protein Structure Database	Q9H2X9 Click to jump to the details page
SWISS-MODEL Database	Q9H2X9 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
6M23	EM	3.2 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A/B
Sequence Length	26-1139		Mutation	No
7D8Z	EM	3.4 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B
Sequence Length	1156		Mutation	No
References
1	RCSB PDB: Molecular basis for regulation of human potassium chloride cotransporters
2	Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv. 2020 Dec 11;6(50):eabc5883.

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