Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0086 Transporter Info
Gene Name SLC12A5
Transporter Name Electroneutral potassium-chloride cotransporter 2
Gene ID
57468
UniProt ID
Q9H2X9

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        FOS 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [1]

TF Protein Name

 Protein c-Fos Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein c-Fos (FOS) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [2]

TF Protein Name

 Fos-related antigen 1 Transcription Factor Info

Tissue

 Bone marrow; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 1 (FOSL1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [3]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Bone marrow; Coronary artery; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A5 gene in breast cancer condition [4]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC12A5 gene in breast cancer condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        TCF12 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 Transcription factor 12 Transcription Factor Info

Tissue

 Blood; Embryo; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor 12 (TCF12) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [1]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A5 gene in glioblastoma multiforme condition [6]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC12A5 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        USF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A5 gene in brain neuroblastoma condition [7]

TF Protein Name

 Upstream stimulatory factor 1 Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Mouse neuroblastoma cells (neuro-2a)

Detailed Description

 Upstream stimulatory factor 1 (USF1) has been reported to activate the transcription of SLC12A5 gene in brain neuroblastoma condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        USF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A5 gene in brain neuroblastoma condition [7]

TF Protein Name

 Upstream stimulatory factor 2 Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Mouse neuroblastoma cells (neuro-2a)

Detailed Description

 Upstream stimulatory factor 2 (USF2) has been reported to activate the transcription of SLC12A5 gene in brain neuroblastoma condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [3]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 10 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [3]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        EGR1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A5 gene in erythroleukemia condition [8]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC12A5 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

       Transcriptional Phenomenon2

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Early growth response protein 1 (EGR1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        EGR4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A5 gene in brain neuroblastoma condition [9]

TF Protein Name

 Early growth response protein 4 Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Mouse neuroblastoma cells (neuro-2a)

Detailed Description

 Early growth response protein 4 (EGR4) has been reported to activate the transcription of SLC12A5 gene in brain neuroblastoma condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [1]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [1]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [2]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        SP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [2]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Embryo; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Sp1 (SP1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        SP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [3]

TF Protein Name

 Transcription factor Sp4 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Sp4 (SP4) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A5 gene in multiple human cancer types condition [10]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC12A5 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        PBX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [3]

TF Protein Name

 Pre-B-cell leukemia transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class3.2: Paired box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PAX5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [2]

TF Protein Name

 Paired box protein Pax-5 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Paired box protein Pax-5 (PAX5) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [2]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        FOXA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A5 gene in prostate cancer condition [11]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC12A5 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

       Transcriptional Phenomenon2

 Direct binding to SLC12A5 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [3]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [1]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Tissue

 Blood; Breast; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [3]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [3]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [5]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [1]

TF Protein Name

 Lysine-specific demethylase 5B Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [2]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A5 gene in glioblastoma multiforme condition [6]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC12A5 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 2.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A5 gene [1]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 1 (RUNX1) can directly bind to the SLC12A5 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 2.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
5 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-250. (ID:ENSG00000124140)
6 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
7 Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2. Brain Res. 2008 Oct 21;1236:8-15.
8 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
9 Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4. J Neurosci. 2006 Dec 27;26(52):13463-73.
10 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
11 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.

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