Transcription Factor (TF) Information

General Information of This TF
TF ID
TFD0144
TF name
Runt-related transcription factor 1 (RUNX1)
Synonyms
AML1; Acute myeloid leukemia 1 protein; CBF-alpha-2; CBFA2; Core-binding factor subunit alpha-2; Oncogene AML-1; PEA2-alpha B; PEBP2-alpha B; Polyomavirus enhancer-binding protein 2 alpha B subunit; RUNX1; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit
Gene Name
RUNX1
Gene ID
861
TF Classification Superclass Immunoglobulin fold
Class Runt domain factors
Family Runt-related factors
Subfamily Other factors
Function This transcription factor modulates the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3'.
Sequence
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPG
ELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA
TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR
QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQM
QDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDL
TAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPG
SSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLP
NQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY
Uniprot ID
RUNX1_HUMAN
Ensembl ID
ENSG00000159216
HGNC ID
HGNC:10471
JASPAR ID
MA0002.1
TF Binding Frequency Matrix TFD0144
Drug Transporter(s) Regulated by This TF

Activation

OCTN1

 Transporter Info

Rheumatoid arthritis [ICD11: FA20]

 [1]

Direct binding

ABCB6

 Transporter Info

ChIP sequencing in blood; bone; bone marrow; umbilical cord blood

 [2]

GLUT3

 Transporter Info

ChIP sequencing in blood; bone; bone marrow; umbilical cord blood

 [2]

KCC2

 Transporter Info

ChIP sequencing in blood; bone; bone marrow

 [3]

SLC23A3

 Transporter Info

ChIP sequencing in blood; bone; bone marrow; umbilical cord blood

 [4]

TAPL

 Transporter Info

ChIP sequencing in blood; bone; bone marrow; umbilical cord blood

 [5]

ZIP11

 Transporter Info

ChIP sequencing in blood; bone; bone marrow

 [5]
Disease-specific Protein Abundances of TF
References
1 Mechanism of the regulation of organic cation/carnitine transporter 1 (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines. Drug Metab Dispos. 2007 Mar;35(3):394-401.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-469.
4 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.