Drug Transporter (DT) Information

General Information of DT
DT ID DTD0339
Gene Name SLC39A11
Protein Name Zinc transporter ZIP11
Gene ID
201266
UniProt ID
Q8N1S5
TCDB ID
2.A.5.5.2
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5TSA_A

Identity:38.125%

Minimized Score:-297.361 kcal/mol

Detail: Structure Info

Synonyms C17orf26; SLC39A11; Solute carrier family 39 member 11; ZIP-11; ZIP11; Zinc transporter ZIP11
DT Family Zinc (Zn(2+))-Iron (Fe(2+)) Permease (ZIP) Family ;
Function This transporter mediates the transport of cellular zinc.
Endogenous Substrate(s) Zn2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Zinc transporter ZIP11
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Zinc transporter ZIP11
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Zinc transporter ZIP11
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Zinc transporter ZIP11
Microbiota Influence (MBI)

(β) Post-translational Modification of Zinc transporter ZIP11
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Zinc transporter ZIP11
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Zinc transporter ZIP11
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Zinc transporter ZIP11
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Zinc transporter ZIP11
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Zinc transporter ZIP11
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Zinc salts
 Preclinical Drug Info Arthritis FA5Z [1]
References
1 Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr. 2013 Dec;143(12):1882-8.

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