Drug Transporter (DT) Information

General Information of DT
DT ID DTD0085
Gene Name SLC12A4
Protein Name Electroneutral potassium-chloride cotransporter 1
Gene ID
6560
UniProt ID
Q9UP95
TCDB ID
2.A.30.1.17
3D Structure

Crystal Structure

Crystallisation Method:EM

PDB ID:6KKR

Corresponding Chain:A/B

Sequence Length:1-1085

Detail: Struture Info

Synonyms Erythroid K-Cl cotransporter 1; hKCC1; KCC1; SLC12A4; Solute carrier family 12 member 4
DT Family Cation-Chloride Cotransporter (CCC) Family ;
Tissue Specificity Ubiquitous. Levels are much higher inerythrocytes from patients with Hb SC and Hb SS compared to normalAA erythrocytes. This may contribute to red blood cell dehydrationand to the manifestation of sickle cell disease by increasing theintracellular concentration of HbS. Isoform 1 was not detected incirculating reticulocytes.
Function This transporter mediates electroneutral potassium-chloride cotransport when activated by cell swelling. And it may be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia.
Endogenous Substrate(s) Chloride
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Electroneutral potassium-chloride cotransporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Electroneutral potassium-chloride cotransporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Electroneutral potassium-chloride cotransporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Electroneutral potassium-chloride cotransporter 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Electroneutral potassium-chloride cotransporter 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Electroneutral potassium-chloride cotransporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Electroneutral potassium-chloride cotransporter 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Electroneutral potassium-chloride cotransporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Electroneutral potassium-chloride cotransporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Potassium chloride
 Approved Drug Info Hypokalemia 5C77 [1]
References
1 Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element. Blood. 2004 Jun 1;103(11):4302-9.

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