Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0085 Transporter Info | |||||
| Gene Name | SLC12A4 | |||||
| Transporter Name | Electroneutral potassium-chloride cotransporter 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Experimental Structures of This DT | ||||||
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| Detail Information of Experimental Structure | ||||||
| PDB ID | 6KKR | [ 1 ] | ||||
| Method | EM | |||||
| Expression System | Homo sapiens | |||||
| Resolution | 2.9 Å | |||||
| Corresponding chain | A/B | |||||
| Sequence length | 1-1085 | |||||
| Mutation | No | |||||
| Publication Year | 2019 | |||||
| AlphaFold Protein Structure Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 6KKT | EM | 2.9 Å | Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | A/B | |||||
| Sequence Length | 1-1085 | Mutation | No | |||
| 6KKU | EM | 3.5 Å | Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | A/B | |||||
| Sequence Length | 1-1085 | Mutation | No | |||
| 7AIP | EM | 3.12 Å | Homo sapiens | [2] | ||
| Structure | ||||||
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| Corresponding chain | A/B | |||||
| Sequence Length | 1074 | Mutation | No | |||
| 7AIQ | EM | 3.72 Å | Homo sapiens | [2] | ||
| Structure | ||||||
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| Corresponding chain | A/B | |||||
| Sequence Length | 1074 | Mutation | No | |||
| 7AIR | EM | 3.66 Å | Homo sapiens | [2] | ||
| Structure | ||||||
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| Corresponding chain | B | |||||
| Sequence Length | 1074 | Mutation | No | |||
| 7TTH | EM | 3.25 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1085 | Mutation | No | |||
| 7TTI | EM | 3.5 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1085 | Mutation | No | |||
| References | ||||||
| 1 | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science. 2019 Oct 25;366(6464):505-508. | |||||
| 2 | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. EMBO J. 2021 Jul 15;40(14):e107294. | |||||
| 3 | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc Natl Acad Sci U S A. 2022;119(27):e2109083119. | |||||
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