Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0085 Transporter Info
Gene Name	SLC12A4
Transporter Name	Electroneutral potassium-chloride cotransporter 1
Gene ID	6560
UniProt ID	Q9UP95

Post-Translational Modification of This DT
Overview ofSLC12A4 Modification Sites with Functional and Structural Information
Sequence	M P H F T V V P V D G P R R G D Y D N L E G L S W V D Y G E R A E L D D S D G H G N H R E S S P F L S P L E A S R G I D Y Y D R N L A L F E E E L D I R P K V S S L L G K L V S Y T N L T Q G A K E H E E A E S G E G T R R R A A E A P S M G T L M G V Y L P C L Q N I F G V I L F L R L T W M V G T A G V L Q A L L I V L I C C C C T L L T A I S M S A I A T N G V V P A G G S Y F M I S R S L G P E F G G A V G L C F Y L G T T F A A A M Y I L G A I E I L L T Y I A P P A A I F Y P S G A H D T S N A T L N N M R V Y G T I F L T F M T L V V F V G V K Y V N K F A S L F L A C V I I S I L S I Y A G G I K S I F D P P V F P V C M L G N R T L S R D Q F D I C A K T A V V D N E T V A T Q L W S F F C H S P N L T T D S C D P Y F M L N N V T E I P G I P G A A A G V L Q E N L W S A Y L E K G D I V E K H G L P S A D A P S L K E S L P L Y V V A D I A T S F T V L V G I F F P S V T G I M A G S N R S G D L R D A Q K S I P V G T I L A I I T T S L V Y F S S V V L F G A C I E G V V L R D K Y G D G V S R N L V V G T L A W P S P W V I V I G S F F S T C G A G L Q S L T G A P R L L Q A I A K D N I I P F L R V F G H G K V N G E P T W A L L L T A L I A E L G I L I A S L D M V A P I L S M F F L M C Y L F V N L A C A V Q T L L R T P N W R P R F K Y Y H W A L S F L G M S L C L A L M F V S S W Y Y A L V A M L I A G M I Y K Y I E Y Q G A E K E W G D G I R G L S L S A A R Y A L L R L E E G P P H T K N W R P Q L L V L L K L D E D L H V K Y P R L L T F A S Q L K A G K G L T I V G S V I Q G S F L E S Y G E A Q A A E Q T I K N M M E I E K V K G F C Q V V V A S K V R E G L A H L I Q S C G L G G M R H N S V V L G W P Y G W R Q S E D P R A W K T F I D T V R C T T A A H L A L L V P K N I A F Y P S N H E R Y L E G H I D V W W I V H D G G M L M L L P F L L R Q H K V W R K C R M R I F T V A Q M D D N S I Q M K K D L A V F L Y H L R L E A E V E V V E M H N S D I S A Y T Y E R T L M M E Q R S Q M L R Q M R L T K T E R E R E A Q L V K D R H S A L R L E S L Y S D E E D E S A V G A D K I Q M T W T R D K Y M T E T W D P S H A P D N F R E L V H I K P D Q S N V R R M H T A V K L N E V I V T R S H D A R L V L L N M P G P P R N S E G D E N Y M E F L E V L T E G L E R V L L V R G G G R E V I T I Y S
PTM type	X-Acetylation X-Malonylation X-N-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	85
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC12A4 Lysine 85 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A4			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	535
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC12A4 Lysine 535 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A4			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	943
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC12A4 Lysine 943 has the potential to affect its expression or activity.
Malonylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	769
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at SLC12A4 Lysine 769 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	245
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC12A4 Asparagine 245 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A4			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	312
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC12A4 Asparagine 312 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A4			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	331
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC12A4 Asparagine 331 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A4			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	347
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC12A4 Asparagine 347 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC12A4			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	439
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC12A4 Asparagine 439 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[5]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	762
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC12A4 Cystine 762 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A4			[5]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	781
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC12A4 Cystine 781 has the potential to affect its expression or activity.
Phosphorylation
Glutamicacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[6]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	969
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Glutamicacid 969 has the potential to affect its expression or activity.
Serine	19 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	May regulate the activity of SLC12A4			[7]
Role of PTM	Protein Activity Modulation
Modified Residue	Serine	Modified Location	506
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 506 have been reported to regulate its transport activity.
PTM Phenomenon2	Have the potential to influence SLC12A4			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	24
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 24 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A4			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 37 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A4			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	46
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 46 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC12A4			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	47
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 47 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC12A4			[9], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	51
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 51 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC12A4			[13], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	56
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 56 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC12A4			[13], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	80
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 80 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC12A4			[13], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 81 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC12A4			[9], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	88
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 88 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC12A4			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	104
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 104 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC12A4			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	669
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 669 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC12A4			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	671
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 671 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC12A4			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	836
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 836 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC12A4			[14], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	958
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 958 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC12A4			[23], [24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	964
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 964 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence SLC12A4			[23], [25]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	967
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 967 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence SLC12A4			[26], [27]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	973
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 973 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence SLC12A4			[28]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1014
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Serine 1014 has the potential to affect its expression or activity.
Threonine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[17], [29]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	90
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Threonine 90 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A4			[6], [20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	93
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Threonine 93 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A4			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	108
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Threonine 108 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A4			[13], [30]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	926
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Threonine 926 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC12A4			[9], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	983
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Threonine 983 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC12A4			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	985
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Threonine 985 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[31]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	991
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Threonine 991 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[31]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	993
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Threonine 993 has the potential to affect its expression or activity.
Tyrosine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[12], [32]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	17
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 17 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A4			[33]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	28
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 28 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A4			[32], [34]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	61
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 61 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A4			[32], [34]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	62
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 62 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC12A4			[17], [34]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	89
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 89 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC12A4			[35], [36]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	708
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 708 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC12A4			[27], [37]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	966
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 966 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC12A4			[28]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	989
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 989 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC12A4			[38]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1056
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 Tyrosine 1056 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Affecting the activity of the SLC12A4			[39]
Role of PTM	Protein Activity Modulation
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A4 have been reported to affect its transport activity.
Ubiquitination
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[40]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	537
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Asparagine 537 has the potential to affect its expression or activity.
Lysine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	78
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 78 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A4			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	85
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 85 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A4			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	97
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 97 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A4			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	535
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 535 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC12A4			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	659
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 659 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC12A4			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	707
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 707 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	719
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 719 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	719
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 719 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC12A4			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	988
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 988 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC12A4			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1010
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Lysine 1010 has the potential to affect its expression or activity.
Proline	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[40]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	709
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Proline 709 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A4			[40]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	87
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A4 Valine 87 has the potential to affect its expression or activity.

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23	Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun. 2019 Jan 10;10(1):104.
24	Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells. Front Microbiol. 2018 Dec 17;9:3083.
25	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
26	Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target. Nat Commun. 2018 Sep 11;9(1):3679.
27	Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL. Blood Adv. 2018 Oct 9;2(19):2554-2567.
28	Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways. Proteomics. 2010 Mar;10(5):976-86.
29	Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells. Mol Cell Proteomics. 2017 Jul;16(7):1365-1376.
30	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
31	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
32	Sensitive, Robust, and Cost-Effective Approach for Tyrosine Phosphoproteome Analysis. Anal Chem. 2017 Sep 5;89(17):9307-9314.
33	Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nat Chem Biol. 2016 Nov;12(11):959-966.
34	Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome. Sci Rep. 2017 Jul 3;7(1):4513.
35	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
36	Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.
37	Modulation of Cl- signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT. Sci Signal. 2018 Oct 30;11(554):eaat5018.
38	Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue. Am J Physiol Cell Physiol. 2000 Sep;279(3):C860-7.
39	Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. EMBO J. 2021 Jul 15;40(14):e107294.
40	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.
41	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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