Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0083 Transporter Info
Gene Name	SLC12A2
Transporter Name	Basolateral Na-K-Cl symporter
Gene ID	6558
UniProt ID	P55011

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC12A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid results in decreased methylation of SLC12A2 gene		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Valproic Acid results in increased expression of SLC12A2 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Ethacrynic Acid inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Ethacrynic Acid results in decreased activity of SLC12A2 protein		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of SLC12A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estradiol results in decreased expression of SLC12A2 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Estradiol results in increased expression of SLC12A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Furosemide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Furosemide results in decreased activity of SLC12A2 protein		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Bumetanide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Bumetanide results in decreased activity of SLC12A2 protein		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SLC12A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Selenium co-treated with Vitamin E results in decreased expression of SLC12A2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Ticrynafen inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Ticrynafen results in decreased activity of SLC12A2 protein		[9]
Regulation Mechanism			Transcription Factor Info
2,3-bis(3'-hydroxybenzyl)butyrolactone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SLC12A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC12A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC12A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
azosemide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	azosemide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	azosemide results in decreased activity of SLC12A2 protein		[9]
Regulation Mechanism			Transcription Factor Info
beta-lapachone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-lapachone results in decreased expression of SLC12A2 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of SLC12A2 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC12A2 gene		[50]
Regulation Mechanism			Transcription Factor Info
Chenodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC12A2 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
Dactinomycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dactinomycin co-treated with nutlin 3 results in increased secretion of SLC12A2 protein		[52]
Regulation Mechanism			Transcription Factor Info
daidzein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	daidzein results in decreased expression of SLC12A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
Deoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC12A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
fasudil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	fasudil results in increased expression of SLC12A2 protein		[30]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of SLC12A2 protein		[53]
Regulation Mechanism			Transcription Factor Info
glycitein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	glycitein results in decreased expression of SLC12A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
Glycochenodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Glycocholic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Glycodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel chloride results in increased expression of SLC12A2 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
nutlin 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dactinomycin co-treated with nutlin 3 results in increased secretion of SLC12A2 protein		[52]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC12A2 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
Paclitaxel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC12A2 protein results in decreased susceptibility to Paclitaxel		[56]
Regulation Mechanism			Transcription Factor Info
piretanide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	piretanide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	piretanide results in decreased activity of SLC12A2 protein		[9]
Regulation Mechanism			Transcription Factor Info
Rubidium	8 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	azosemide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Bumetanide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Ethacrynic Acid inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Furosemide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	piretanide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Ticrynafen inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Torsemide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
Selenium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Selenium co-treated with Vitamin E results in decreased expression of SLC12A2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC12A2 mRNA		[58]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC12A2 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of SLC12A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in increased expression of SLC12A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
Torsemide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Torsemide inhibits the reaction SLC12A2 protein results in increased uptake of Rubidium		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Torsemide results in decreased activity of SLC12A2 protein		[9]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC12A2 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Vanadium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanadium results in increased expression of SLC12A2 mRNA		[61]
Regulation Mechanism			Transcription Factor Info
Y 27632	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Y 27632 results in increased expression of SLC12A2 protein		[30]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Diethylstilbestrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diethylstilbestrol inhibits the expression of SLC12A2		[1]
Estrone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estrone inhibits the expression of SLC12A2		[1]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of SLC12A2		[3]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLC12A2		[4]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of SLC12A2		[5]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC12A2		[6]
Valproic Acid	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC12A2		[7]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin affects the expression of SLC12A2		[8]
Ethacrynic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethacrynic Acid inhibits the activity of SLC12A2		[9]
Torasemide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Torasemide inhibits the activity of SLC12A2		[9]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC12A2		[10]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC12A2		[11]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC12A2		[12]
Acetaminophen	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC12A2		[13]
DT Modulation2	Acetaminophen affects the expression of SLC12A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of SLC12A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Glyburide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glibenclamide inhibits the activity of SLC12A2		[14]
Estradiol	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol induces the activity of SLC12A2		[15]
Furosemide	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the activity of SLC12A2		[16], [17]
Bumetanide	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bumetanide inhibits the activity of SLC12A2		[18], [19]
Nitroprusside	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nitroprusside inhibits the activity of SLC12A2		[20]
Phenylephrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylephrine induces the activity of SLC12A2		[20]
Methoxamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methoxamine induces the activity of SLC12A2		[21]
Oxytocin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxytocin induces the activity of SLC12A2		[22]
Kanamycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Kanamycin inhibits the activity of SLC12A2		[23], [24]
Verteporfin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Verteporfin inhibits the activity of SLC12A2		[25]
Drug Marketed but not Approved by US FDA
Estriol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estriol inhibits the expression of SLC12A2		[1]
Daidzein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Daidzein inhibits the expression of SLC12A2		[2]
Drug in Phase 3 Trial
Vitamin E	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin E inhibits the expression of SLC12A2		[28]
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the expression of SLC12A2		[2]
Drug in Phase 1 Trial
Fasudil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fasudil increases the expression of SLC12A2		[30]
Quercetin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC12A2		[31]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 increases the expression of SLC12A2		[36]
Nitric oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nitric oxide inhibits the activity of SLC12A2		[20]
Investigative Drug
Glycitein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycitein inhibits the expression of SLC12A2		[2]
Coumestrol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol inhibits the expression of SLC12A2		[27]
Drug Withdrawn
Ticrynafen	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ticrynafen inhibits the activity of SLC12A2		[9]
Natural Product
DT Modulation1	Quercetin results in increased activity of SLC12A2 protein		[57]
Regulation Mechanism			Transcription Factor Info
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of SLC12A2		[33]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC12A2		[41]
Gallic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gallic Acid increases the expression of SLC12A2		[42]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine affects the phosphorylation of SLC12A2 protein		[49]
Regulation Mechanism			Transcription Factor Info
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Jinfukang inhibits the expression of SLC12A2		[40]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLC12A2		[29]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC12A2		[32]
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC12A2 gene		[46]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel chloride increases the expression of SLC12A2		[26]
Thimerosal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thimerosal increases the expression of SLC12A2		[39]
Carcinogen
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC12A2		[34]
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate inhibits the expression of SLC12A2		[35]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC12A2 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel results in decreased expression of SLC12A2 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of SLC12A2		[37]
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC12A2		[38]

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9	Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Sci Rep. 2018 Jun 29;8(1):9877.
10	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
11	Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975.
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42	Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743.
43	Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
44	Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9.
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55	A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
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57	Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium. Am J Respir Cell Mol Biol. 2009;41(6):688-95.
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59	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
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