Drug Transporter (DT) Information

General Information of DT
DT ID DTD0189
Gene Name SLC25A28
Protein Name Mitochondrial iron transporter 2
Gene ID
81894
UniProt ID
Q96A46
TCDB ID
2.A.29.5.8
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms Mitochondrial RNA-splicing protein 3/4 homolog; MRS3/4; hMRS3/4; Solute carrier family 25 member 28; SLC25A28; MFRN2; NPD016; Mitoferrin-2
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Ubiquitous. Expressed in placenta, lung,kidney, pancreas, liver, brain, skeletal muscle and heart.
Function This mitochondrial transporter mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme.
Endogenous Substrate(s) Iron
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Mitochondrial iron transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Mitochondrial iron transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Mitochondrial iron transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Mitochondrial iron transporter 2
Microbiota Influence (MBI)

(β) Post-translational Modification of Mitochondrial iron transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Mitochondrial iron transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Mitochondrial iron transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Mitochondrial iron transporter 2
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Mitochondrial iron transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Mitochondrial iron transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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