Drug Transporter (DT) Information

General Information of DT
DT ID DTD0345
Gene Name SLC39A4
Protein Name Zinc transporter ZIP4
Gene ID
55630
UniProt ID
Q6P5W5
TCDB ID
2.A.5.4.1
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4X82_A

Identity:68.013%

Minimized Score:-597.421 kcal/mol

Detail: Structure Info

Synonyms AEZ; AWMS2; SLC39A4; Solute carrier family 39 member 4; ZIP-4; ZIP4; Zinc transporter ZIP4
DT Family Zinc (Zn(2+))-Iron (Fe(2+)) Permease (ZIP) Family ;
Tissue Specificity Highly expressed in kidney, small intestine,stomach, colon, jejunum and duodenum.
Function This transporter regulated in response to zinc availability and plays an important role in cellular zinc homeostasis as a zinc transporter.
Endogenous Substrate(s) Zn2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Zinc transporter ZIP4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Zinc transporter ZIP4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Zinc transporter ZIP4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Zinc transporter ZIP4
Microbiota Influence (MBI)

(β) Post-translational Modification of Zinc transporter ZIP4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Zinc transporter ZIP4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Zinc transporter ZIP4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Zinc transporter ZIP4
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Zinc transporter ZIP4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Zinc transporter ZIP4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Zinc salts
 Preclinical Drug Info Arthritis FA5Z [1]
References
1 Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet. 2014 Feb 20;10(2):e1004128.

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