Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0270 | ||||
| Gene Name | SLC30A10 | ||||
| Protein Name | Zinc transporter 10 | ||||
| Gene ID | |||||
| UniProt ID | |||||
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| 3D Structure |
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| Synonyms | HMDPC; HMNDYT1; Manganese transporter SLC30A10; SLC30A10; Solute carrier family 30 member 10; ZNT10; ZnT-10 | ||||
| DT Family | Cation Diffusion Facilitator (CDF) Family ; | ||||
| Tissue Specificity | Specifically expressed in fetal liver andfetal brain (PubMed:15154973). Expressed in adult tissues withrelative levels small intestine > liver > testes > brain > ovary >colon > cervix > prostate > placenta (PubMed:22706290). | ||||
| Function | This transporter mediates the effux of manganese and confers protection against manganese-induced cell death, plays a pivotal role in manganese transport. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells. | ||||
| Endogenous Substrate(s) | Zn2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Zinc transporter 10 |
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(β) Cell Distribution Level of Zinc transporter 10 |
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(γ) Organelle Distribution Level of Zinc transporter 10 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Zinc transporter 10 |
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(β) Post-translational Modification of Zinc transporter 10 |
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(γ) Transcriptional Regulation of Zinc transporter 10 |
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(δ) Epigenetic Regulation of Zinc transporter 10 |
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(ε) Exogenous Modulation of Zinc transporter 10 |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Zinc transporter 10 |
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(β) Disease-specific Protein Abundances of Zinc transporter 10 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Withdrawn, Discontinued or Preclinical Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Zinc salts
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Preclinical | Drug Info | Arthritis | FA5Z | [1] |
| References | |||||
| 1 | Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. Am J Hum Genet. 2012 Mar 9;90(3):467-77. | ||||
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