Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0270 Transporter Info
Gene Name SLC30A10
Transporter Name Zinc transporter 10
Gene ID
55532
UniProt ID
Q6XR72

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        ATF4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in neurodegenerative diseases condition [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-4 Transcription Factor Info

Affected Drug/Substrate

 Manganese

Studied Phenotype

 Neurodegenerative diseases [ICD11: 8A20-8A2Z]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6N mice

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-4 (ATF4) has been reported to activate the transcription of SLC30A10 gene in neurodegenerative diseases condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

       Transcriptional Phenomenon2

 Activation of SLC30A10 gene in health condition [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-4 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Brain

Related DT Changes

 up regulating

Experimental Material

 C57BL/6N mice

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-4 (ATF4), influenced by the exogenous 1-methyl-4-phenylpyridinium, has been reported to activate the transcription of SLC30A10 gene in health condition , which leads to an increased expression of the drug transporter Zinc transporter 10.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A10 gene in coronary artery disease condition [2]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC30A10 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Zinc transporter 10.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC30A10 gene in hepatoblastoma condition [3]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

 Zinc

Studied Phenotype

 Hepatoblastoma [ICD11: 2C12.01]

Tissue

 Liver

Related DT Changes

 down regulating

Experimental Material

 Human hepatoblastoma cells (HepG2)

Detailed Description

 Aryl hydrocarbon receptor (AHR), influenced by the exogenous beta-naphthoflavone, has been reported to repress the transcription of SLC30A10 gene in hepatoblastoma condition , which leads to a decreased expression of the drug transporter Zinc transporter 10.

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in manganese excess condition [4]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

 Manganese

Studied Phenotype

 Manganese excess [ICD11: 5B91.5]

Tissue

 Small intestine

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC30A10 gene in manganese excess condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

        ARNT2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in manganese excess condition [4]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator 2 Transcription Factor Info

Affected Drug/Substrate

 Manganese

Studied Phenotype

 Manganese excess [ICD11: 5B91.5]

Tissue

 Small intestine

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) has been reported to activate the transcription of SLC30A10 gene in manganese excess condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

        EPAS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in manganese excess condition [4]

TF Protein Name

 Endothelial PAS domain-containing protein 1 Transcription Factor Info

Affected Drug/Substrate

 Manganese

Studied Phenotype

 Manganese excess [ICD11: 5B91.5]

Tissue

 Small intestine

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to activate the transcription of SLC30A10 gene in manganese excess condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

        HIF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in manganese excess condition [4]

TF Protein Name

 Hypoxia-inducible factor 1-alpha Transcription Factor Info

Affected Drug/Substrate

 Manganese

Studied Phenotype

 Manganese excess [ICD11: 5B91.5]

Tissue

 Small intestine

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC30A10 gene in manganese excess condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC30A10 gene in medulloblastoma condition [5]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC30A10 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Zinc transporter 10.

        TCF4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in colorectal cancer condition [6]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC30A10 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

       Transcriptional Phenomenon2

 Binding to SLC30A10 gene in glioblastoma multiforme condition [7]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC30A10 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Zinc transporter 10.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A10 gene [8]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC30A10 gene in . condition, which leads to a affected expression of the drug transporter Zinc transporter 10.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A10 gene in health condition [9]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC30A10 gene in health condition, which leads to an affected expression of the drug transporter Zinc transporter 10.

        NR3C1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in ER(-) breast cancer condition [10]

TF Protein Name

 Glucocorticoid receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC30A10 gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC30A10 gene in myofibroblast condition [11]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC30A10 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Zinc transporter 10.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in colon cancer condition [12]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC30A10 gene in colon cancer condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A10 gene in hematopoiesis condition [13]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC30A10 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Zinc transporter 10.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in hematopoiesis condition [13]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC30A10 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

        GATA6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in gastric cancer condition [14]

TF Protein Name

 Transcription factor GATA-6 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC30A10 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A10 gene in erythroleukemia condition [15]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC30A10 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Zinc transporter 10.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in podocyte condition [16]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC30A10 gene in podocyte condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in renal cysts condition [17]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC30A10 gene in renal cysts condition, which leads to an increased expression of the drug transporter Zinc transporter 10.

        HOXB13 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A10 gene [18]

TF Protein Name

 Homeobox protein Hox-B13 Transcription Factor Info

Tissue

 Colon; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Homeobox protein Hox-B13 (HOXB13) can directly bind to the SLC30A10 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 10.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A10 gene [19]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC30A10 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 10.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        STAT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A10 gene [20]

TF Protein Name

 Signal transducer and activator of transcription 1-alpha/beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 1-alpha/beta (STAT1) has been reported to bind to the transcription of SLC30A10 gene in . condition, which leads to an affected expression of the drug transporter Zinc transporter 10.

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A10 gene in glioblastoma multiforme condition [7]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC30A10 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Zinc transporter 10.
References
1 Protective function of SLC30A10 induced via PERK-ATF4 pathway against 1-methyl-4-phenylpyridinium. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1307-1313.
2 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
3 beta-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019;44(10):711-720.
4 Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2107673118.
5 Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
6 Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol. 2008;28(8):2732-44.
7 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
8 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
9 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
10 Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011;71(20):6360-70.
11 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
12 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
13 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
14 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
15 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
16 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
17 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
18 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
19 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-439. (ID:ENSG00000196660)
20 MER41 repeat sequences contain inducible STAT1 binding sites. PLoS One. 2010;5(7):e11425.

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