Drug Transporter (DT) Information

General Information of DT
DT ID DTD0346
Gene Name SLC39A5
Protein Name Zinc transporter ZIP5
Gene ID
283375
UniProt ID
Q6ZMH5
TCDB ID
2.A.5.4.10
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5L3B_A; 5TSA_A

Identity:46.341%;30.519%

Minimized Score:-219.699 kcal/mol

Detail: Structure Info

Synonyms LZT-Hs7; MYP24; SLC39A5; Solute carrier family 39 member 5; ZIP-5; ZIP5; Zinc transporter ZIP5
DT Family Zinc (Zn(2+))-Iron (Fe(2+)) Permease (ZIP) Family ;
Tissue Specificity Expressed in liver, kidney, pancreas, smallintestine, colon, spleen, fetal liver and fetal kidney.
Function This transporter seems to play a central role in controlling organismal zinc status and may play a role in polarized cells by carrying out serosal-to-mucosal zinc transport.
Endogenous Substrate(s) Zn2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Zinc transporter ZIP5
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Zinc transporter ZIP5
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Zinc transporter ZIP5
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Zinc transporter ZIP5
Microbiota Influence (MBI)

(β) Post-translational Modification of Zinc transporter ZIP5
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Zinc transporter ZIP5
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Zinc transporter ZIP5
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Zinc transporter ZIP5
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Zinc transporter ZIP5
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Zinc transporter ZIP5
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Zinc salts
 Preclinical Drug Info Arthritis FA5Z [1]

Drug-DT Affinity Assessed by Cell Line

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:         25 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
Zinc salts Preclinical Drug Info Human embryonic kidney cells (HEK293)-ZIP5 Km =2.1 microM [1]
References
1 The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J Biol Chem. 2004 Dec 3;279(49):51433-41.

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