Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0346 Transporter Info
Gene Name SLC39A5
Transporter Name Zinc transporter ZIP5
Gene ID
283375
UniProt ID
Q6ZMH5
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Approved Drug

  Copper Sulfate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Copper Sulfate inhibits the expression of SLC39A5 [1]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of SLC39A5 [2]

  Valproic Acid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid inhibits the expression of SLC39A5 [3]

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen inhibits the expression of SLC39A5 [4]

Drug in Phase 2 Trial

  Bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol A affects the expression of SLC39A5 [11]

Drug in Phase 1 Trial

  Quercetin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Quercetin affects the expression of SLC39A5 [7]

  Sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium arsenite inhibits the expression of SLC39A5 [10]

Drug in Preclinical Test

  (+)-JQ1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 (+)-JQ1 inhibits the expression of SLC39A5 [9]

Investigative Drug

  Octanal

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Octanal inhibits the expression of SLC39A5 [8]

  Beta-naphthoflavone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Beta-naphthoflavone inhibits the expression of SLC39A5 [12]

Natural Product

  Heptanal

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Heptanal inhibits the expression of SLC39A5 [8]

  Methyleugenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methyleugenol inhibits the expression of SLC39A5 [13]

Plant Extract

  Grape Seed Proanthocyanidins

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Grape Seed Proanthocyanidins inhibits the expression of SLC39A5 [6]

Environmental toxicant

  Zinc

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zinc inhibits the expression of SLC39A5 [5]

Regulation Mechanism

 via enhancement of Metal regulatory transcription factor 1 (MTF1) Transcription Factor Info

Cell System

 Yellow catfish

Mycotoxins

  Aflatoxin B1

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 inhibits the expression of SLC39A5 [14]

  DT Modulation2

 Aflatoxin B1 affects the expression of SLC39A5 protein [17]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  Benzo(a)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene inhibits the expression of SLC39A5 [13]

Health and Environmental Toxicant

  Butyraldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Butyraldehyde inhibits the expression of SLC39A5 [15]

Chemical Compound

  DT Modulation1

 Valproic Acid affects the expression of SLC39A5 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 SLC39A5 protein results in increased transport of Zinc [22]

Regulation Mechanism

 Transcription Factor Info

  Pentanal

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Pentanal inhibits the expression of SLC39A5 [15]

  4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC39A5 protein promotes the reaction 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction Diethylhexyl Phthalate results in increased expression of TNF protein [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 SLC39A5 protein promotes the reaction 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction Diethylhexyl Phthalate results in increased phosphorylation of RELA protein [16]

Regulation Mechanism

 Transcription Factor Info

  beta-lapachone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-lapachone results in decreased expression of SLC39A5 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  beta-Naphthoflavone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-Naphthoflavone results in decreased expression of SLC39A5 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A affects the expression of SLC39A5 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  butyraldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 butyraldehyde results in decreased expression of SLC39A5 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  Cadmium Chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium Chloride results in increased expression of SLC39A5 mRNA [19]

Regulation Mechanism

 Transcription Factor Info

  caprylic aldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 caprylic aldehyde results in decreased expression of SLC39A5 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  Diethylhexyl Phthalate

            9 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Diethylhexyl Phthalate results in increased expression of SLC39A5 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Diethylhexyl Phthalate results in increased expression of SLC39A5 protein [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 SLC39A5 protein promotes the reaction 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction Diethylhexyl Phthalate results in increased expression of TNF protein [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 SLC39A5 protein promotes the reaction 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction Diethylhexyl Phthalate results in increased phosphorylation of RELA protein [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 SLC39A5 protein promotes the reaction Diethylhexyl Phthalate results in increased cleavage of CASP1 protein [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 SLC39A5 protein promotes the reaction Diethylhexyl Phthalate results in increased cleavage of GSDMD protein [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 SLC39A5 protein promotes the reaction Diethylhexyl Phthalate results in increased cleavage of IL1B protein [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation8

 SLC39A5 protein promotes the reaction Diethylhexyl Phthalate results in increased expression of NLRP3 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation9

 SLC39A5 protein promotes the reaction Diethylhexyl Phthalate results in increased expression of NLRP3 protein [16]

Regulation Mechanism

 Transcription Factor Info

  heptanal

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 heptanal results in decreased expression of SLC39A5 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  methyleugenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 methyleugenol results in decreased expression of SLC39A5 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  n-hexanal

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 n-hexanal results in decreased expression of SLC39A5 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  N-Nitrosopyrrolidine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 N-Nitrosopyrrolidine results in decreased expression of SLC39A5 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  Okadaic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Okadaic Acid results in decreased expression of SLC39A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  pentanal

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 pentanal results in decreased expression of SLC39A5 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  propionaldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 propionaldehyde results in decreased expression of SLC39A5 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in decreased expression of SLC39A5 mRNA [10]

Regulation Mechanism

 Transcription Factor Info
References
1 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
2 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
3 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
4 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
5 Dietary zinc addition influenced zinc and lipid deposition in the fore- and mid-intestine of juvenile yellow catfish Pelteobagrus fulvidraco. Br J Nutr. 2017 Oct;118(8):570-579.
6 Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. J Nutr Biochem. 2011 Feb;22(2):153-63.
7 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
8 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
9 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
10 Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells. Toxicol Sci. 2018 Apr 1;162(2):676-687.
11 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134.
12 beta-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019;44(10):711-720.
13 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
14 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
15 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
16 Exposure to Di-(2-Ethylhexyl) phthalate drives ovarian dysfunction by inducing granulosa cell pyroptosis via the SLC39A5/NF-B/NLRP3 axis. Ecotoxicol Environ Saf. 2023;252:114625.
17 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
18 Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway. Chem Biol Interact. 2024;389:110866.
19 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
20 A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
21 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
22 Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008;49(3):1221-31.

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