Drug Transporter (DT) Information

General Information of DT
DT ID DTD0455
Gene Name SLC6A3
Protein Name Sodium-dependent dopamine transporter
Gene ID
6531
UniProt ID
Q01959
TCDB ID
2.A.22.1.3
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4XPB_A

Identity:55.354%

Minimized Score:-1503.772 kcal/mol

Detail: Structure Info

Synonyms DA transporter; DAT; DAT1; PKDYS; PKDYS1; SLC6A3; Solute carrier family 6 member 3
DT Family Neurotransmitter:Sodium Symporter (NSS) Family ;
Tissue Specificity Highly expressed in substantia nigra.
Function This transporter can terminate the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Disease(s) Parkinson's Disease [ICD-11:8A00.0]
Endogenous Substrate(s) Cl-; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-dependent dopamine transporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-dependent dopamine transporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-dependent dopamine transporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium-dependent dopamine transporter
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium-dependent dopamine transporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-dependent dopamine transporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-dependent dopamine transporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-dependent dopamine transporter
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-dependent dopamine transporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-dependent dopamine transporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           4 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Amphetamine
 Approved Drug Info Attention deficit hyperactivity disorder 6A05 [1]
Benztropine
 Approved Drug Info Dystonia 8A02 [2]
Brexpiprazole
 Approved Drug Info Schizophrenia 6A20 [3]
Dopamine
 Approved Drug Info Parkinson's Disease 8A00.0 [4]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Bretylium
 Withdrawn Drug Info Ventricular fibrillation BC71.1 [5]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Dopamine
681
EM Info Identified using the adults with attention-deficit hyperactive disorder [6]
References
1 Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends Pharmacol Sci. 2015 Jan;36(1):41-50.
2 Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. J Pharmacol Exp Ther. 2014 Jan;348(1):106-15.
3 Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania. Psychopharmacology (Berl). 2017 Mar;234(6):1017-1028.
4 Characterization of VNTRs Within the Entire Region of SLC6A3 and Its Association with Hypertension. DNA Cell Biol. 2017 Mar;36(3):227-236.
5 Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species? J Biol Chem. 1999 Feb 19;274(8):4876-82.
6 Attention-deficit hyperactivity disorder in adults: A systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies. Mol Psychiatry. 2016 Jul;21(7):872-84.

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