Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01335
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| Drug Name |
Brexpiprazole
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| Synonyms |
OPC-34712
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| Drug Type |
Small molecular drug
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| Indication | Depression [ICD11:6A8Z] | Approved | [1] | |||
| Schizophrenia [ICD11:6A20] | Approved | [1] | ||||
| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C25H27N3O2S
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| Canonical SMILES |
C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4
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| InChI |
InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29)
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| InChIKey |
ZKIAIYBUSXZPLP-UHFFFAOYSA-N
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| CAS Number |
CAS 913611-97-9
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| Pharmaceutical Properties | Molecular Weight | 433.6 | Topological Polar Surface Area | 73 | ||
| Heavy Atom Count | 31 | Rotatable Bond Count | 7 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
4.7
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| PubChem CID | ||||||
| PubChem SID | ||||||
| ChEBI ID |
CHEBI:134716
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | DAT1 | Transporter Info | Sodium-dependent dopamine transporter | Substrate | [2] | |
| References | ||||||
| 1 | Brexpiprazole was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania. Psychopharmacology (Berl). 2017 Mar;234(6):1017-1028. | |||||
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