Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0455 Transporter Info | |||||
| Gene Name | SLC6A3 | |||||
| Transporter Name | Sodium-dependent dopamine transporter | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 4XPB_A | Identity | 55.354% | |||
| Performance | Minimized Score | -1503.772 kcal/mol | ||||
| Ramachandra Favored | Excellent |
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| QMEANBrane Quality | High |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -0.84 ±0.33 | |||||
| Residues in Favored Region | 539 | Ramachandran favored | 98.36% | |||
| Number of Outliers | 1 | Ramachandran outliers | 0.18% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.82 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8VBY | EM | 3.19 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 571 | Mutation | No | |||
| 8Y2C | EM | 3.16 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 555 | Mutation | No | |||
| 8Y2D | EM | 2.8 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 553 | Mutation | No | |||
| 8Y2E | EM | 3.03 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 555 | Mutation | No | |||
| 8Y2F | EM | 2.97 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 555 | Mutation | No | |||
| 8Y2G | EM | 2.83 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 562 | Mutation | No | |||
| 9EO4 | EM | 2.66 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | B | |||||
| Sequence Length | 660 | Mutation | No | |||
| References | ||||||
| 1 | Structure of the human dopamine transporter and mechanisms of inhibition. Nature. 2024;632(8025):672-677. | |||||
| 2 | Dopamine reuptake and inhibitory mechanisms in human dopamine transporter. Nature. 2024;632(8025):686-694. | |||||
| 3 | Structure of the human dopamine transporter in complex with cocaine. Nature. 2024;632(8025):678-685. | |||||
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