Drug Transporter (DT) Information

General Information of DT
DT ID DTD0418
Gene Name SLC5A1
Protein Name Sodium/glucose cotransporter 1
Gene ID
6523
UniProt ID
P13866
TCDB ID
2.A.21.3.1
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:2XQ2_A

Identity:30.556%

Minimized Score:-991.414 kcal/mol

Detail: Structure Info

Synonyms D22S675; High affinity sodium-glucose cotransporter; NAGT; Na(+)/glucose cotransporter 1; SGLT1; SLC5A1; Solute carrier family 5 member 1
DT Family Solute:Sodium Symporter (SSS) Family ;
Tissue Specificity Expressed mainly in intestine and kidney.
Function This transporter actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1.
Endogenous Substrate(s) Galactose; Na+; Water
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/glucose cotransporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/glucose cotransporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/glucose cotransporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium/glucose cotransporter 1
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium/glucose cotransporter 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/glucose cotransporter 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/glucose cotransporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/glucose cotransporter 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/glucose cotransporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/glucose cotransporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
2-Deoxyglucose
 Phase 1/2 Drug Info Cancer 2A00-2F9Z [1]
Fucose
 Phase 1/2 Drug Info Type 2 leukocyte adhesion deficiency 5C54.2 [1]
References
1 The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977.

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