Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0418 Transporter Info
Gene Name	SLC5A1
Transporter Name	Sodium/glucose cotransporter 1
Gene ID	6523
UniProt ID	P13866

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC5A1 5' UTR			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased methylation of SLC5A1 3' UTR			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of SLC5A1 promoter			[32]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC5A1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
Amphotericin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amphotericin B analog results in increased expression of SLC5A1 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
Apigenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apigenin analog inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
arsenic pentoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	arsenic pentoxide results in decreased expression of SLC5A1 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite results in increased expression of SLC5A1 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Bromosuccinimide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bromosuccinimide affects the oxidation of SLC5A1 protein			[33]
Regulation Mechanism				Transcription Factor Info
caffeic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	caffeic acid results in increased expression of SLC5A1 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
Galactose	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Galactose inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC5A1 protein affects the transport of Galactose			[36]
Regulation Mechanism				Transcription Factor Info
Glucose	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glucose inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC5A1 protein affects the transport of Glucose			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC5A1 protein affects the uptake of Glucose			[37]
Regulation Mechanism				Transcription Factor Info
hydroquinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hydroquinone results in increased expression of SLC5A1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
hyperoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hyperoside analog results in increased expression of SLC5A1 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
isoquercitrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	isoquercitrin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
Lactic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lactic Acid results in decreased expression of SLC5A1 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
Luteolin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Luteolin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
luteolin 4'-O-glucoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	luteolin 4'-O-glucoside inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of SLC5A1 mRNA			[19]
Regulation Mechanism				Transcription Factor Info
methylglucoside	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apigenin analog inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Galactose inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glucose inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	isoquercitrin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	luteolin 4'-O-glucoside inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Luteolin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	naringenin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Phlorhizin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Phlorhizin inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Quercetin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	SLC5A1 protein binds to methylglucoside			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	SLC5A1 protein results in increased uptake of methylglucoside			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	spiraeoside inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
naringenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringenin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
NVP-BKM120	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in decreased expression of SLC5A1 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC5A1 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
perfluorohexanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid results in increased expression of SLC5A1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid results in increased expression of SLC5A1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid results in increased expression of SLC5A1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
Phlorhizin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phlorhizin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Phlorhizin inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC5A1 protein binds to Phlorhizin			[33]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide results in increased expression of SLC5A1 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Sodium	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Galactose inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glucose inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Phlorhizin inhibits the reaction Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sodium co-treated with SLC5A1 protein results in increased uptake of methylglucoside			[35]
Regulation Mechanism				Transcription Factor Info
sodium arsenate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenate results in increased abundance of Arsenic which results in decreased expression of SLC5A1 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of SLC5A1 gene			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased expression of SLC5A1 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
sotorasib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in decreased expression of SLC5A1 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
spiraeoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	spiraeoside inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in increased expression of SLC5A1 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
trametinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in decreased expression of SLC5A1 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
urushiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	urushiol results in increased expression of SLC5A1 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
Zinc	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the reaction SP1 protein binds to Zinc which binds to SLC5A1 promoter			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Zinc inhibits the reaction Cadmium inhibits the reaction SP1 protein binds to Zinc which binds to SLC5A1 promoter			[34]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Dapagliflozin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dapagliflozin inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[5]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)7-SGLT1
Angiotensin II	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Angiotensin II inhibits the transportation of Glucose by SLC5A1			[8]
Affected Drug/Substrate	Glucose	Modulation Type	Inhibition
Hydroquinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydroquinone increases the expression of SLC5A1			[9]
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cannabidiol increases the expression of SLC5A1			[10]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of SLC5A1			[11]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC5A1			[12]
Drug in Phase 3 Trial
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC5A1			[16]
LX-4211	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LX-4211 modulates the activity of SLC5A1			[24]
Drug in Phase 2 Trial
Ethanol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethanol inhibits the expression of SLC5A1			[18]
LIK-066	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LIK-066 inhibits the activity of SLC5A1			[25]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC5A1			[22]
GSK1614235	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK1614235 blocks the activity of SLC5A1			[23]
GSK1614235 + GSK2330672	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK1614235 + GSK2330672 modulates the activity of SLC5A1			[25]
Investigative Drug
Phlorizin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phlorizin inhibits the transportation of 2-Deoxyglucose by SLC5A1			[1]
Affected Drug/Substrate	2-Deoxyglucose	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-SGLT1
DT Modulation2	Phlorizin inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[2]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-SGLT1
DT Modulation3	Phlorizin inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[3]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
DT Modulation4	Phlorizin inhibits the activity of SLC5A1			[4]
Phloretin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phloretin inhibits the transportation of 2-Deoxyglucose by SLC5A1			[1]
Affected Drug/Substrate	2-Deoxyglucose	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-SGLT1
DT Modulation2	Phloretin inhibits the activity of SLC5A1			[4]
Alstiphyllanine D	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alstiphyllanine D inhibits the transportation of Alpha-D-glucopyranoside by SLC5A1			[6]
Affected Drug/Substrate	Alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Alstiphyllanine E	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alstiphyllanine E inhibits the transportation of Alpha-D-glucopyranoside by SLC5A1			[6]
Affected Drug/Substrate	Alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Alstiphyllanine F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alstiphyllanine F inhibits the transportation of Alpha-D-glucopyranoside by SLC5A1			[6]
Affected Drug/Substrate	Alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Formononetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formononetin inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[7]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Kuraidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kuraidin inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[7]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Kurarinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kurarinone inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[7]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Kushenol N	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kushenol N inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[7]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Maackiain	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Maackiain inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[7]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Sophoraflavanone G	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sophoraflavanone G inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[7]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Acerogenin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acerogenin A inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[3]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Acerogenin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acerogenin B inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[3]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Acerogenin C	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acerogenin C inhibits the transportation of Methyl-alpha-D-glucopyranoside by SLC5A1			[3]
Affected Drug/Substrate	Methyl-alpha-D-glucopyranoside	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-SGLT1
Milchsaure	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Milchsaure inhibits the expression of SLC5A1			[17]
Natural Product
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of SLC5A1			[14]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of SLC5A1			[19]
Hyperoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hyperoside increases the expression of SLC5A1			[20]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC5A1			[21]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the reaction SLC5A1 protein results in increased uptake of methylglucoside			[28]
Regulation Mechanism				Transcription Factor Info
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC5A1 protein affects the uptake of Resveratrol			[37]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLC5A1			[13]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	C57BL/6J mice
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC5A1			[19]
Citrinin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrinin co-treated with ochratoxin A results in decreased expression of SLC5A1 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
ochratoxin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrinin co-treated with ochratoxin A results in decreased expression of SLC5A1 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ochratoxin A results in decreased expression of SLC5A1 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ochratoxin A inhibits the expression of SLC5A1			[15]
Carcinogen
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC5A1			[19]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenate results in increased abundance of Arsenic which results in decreased expression of SLC5A1 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
Cadmium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the reaction SP1 protein binds to Zinc which binds to SLC5A1 promoter			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Zinc inhibits the reaction Cadmium inhibits the reaction SP1 protein binds to Zinc which binds to SLC5A1 promoter			[34]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
Caffeic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeic acid increases the expression of SLC5A1			[20]

References
1	Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation. J Med Chem. 2017 Jan 26;60(2):568-579.
2	Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem. 2007 Sep 28;282(39):28501-13.
3	Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1070-4.
4	Probing the conformation of the sugar transport inhibitor phlorizin by 2D-NMR, molecular dynamics studies, and pharmacophore analysis. J Med Chem. 2000 May 4;43(9):1692-8.
5	O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5632-5.
6	Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158.
7	Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.
8	Angiotensin II exerts dual actions on sodium-glucose transporter 1-mediated transport in the human jejunal mucosa. Scand J Gastroenterol. 2015;50(9):1068-75.
9	Keratinocyte-derived IL-36 Gamma plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
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11	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
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