Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0418 Transporter Info | |||||
| Gene Name | SLC5A1 | |||||
| Transporter Name | Sodium/glucose cotransporter 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 2XQ2_A | Identity | 30.556% | |||
| Performance | Minimized Score | -991.414 kcal/mol | ||||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | High |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -1.69 ±0.35 | |||||
| Residues in Favored Region | 446 | Ramachandran favored | 96.75% | |||
| Number of Outliers | 3 | Ramachandran outliers | 0.65% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.8 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 7SL8 | EM | 3.4 Å | Escherichia coli Bl21(de3),Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 673 | Mutation | No | |||
| 7SLA | EM | 3.15 Å | Escherichia coli Bl21(de3),Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 673 | Mutation | No | |||
| 7WMV | EM | 3.2 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 664 | Mutation | No | |||
| 7YNI | EM | 3.26 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 664 | Mutation | No | |||
| References | ||||||
| 1 | Structure and mechanism of the SGLT family of glucose transporters. Nature. 2022;601(7892):274-279. | |||||
| 2 | Structural mechanism of SGLT1 inhibitors. Nat Commun. 2022;13(1):6440. | |||||
| 3 | Structures of human SGLT in the occluded state reveal conformational changes during sugar transport. Nat Commun. 2023;14(1):2920. | |||||
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