Drug Transporter (DT) Information

General Information of DT
DT ID DTD0340
Gene Name SLC39A12
Protein Name Zinc transporter ZIP12
Gene ID
221074
UniProt ID
Q504Y0
TCDB ID
2.A.5.4.14
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms LIV-1 subfamily of ZIP zinc transporter 8; LZT-Hs8; SLC39A12; Solute carrier family 39 member 12; ZIP-12; ZIP12; Zinc transporter ZIP12; bA570F3.1
DT Family Zinc (Zn(2+))-Iron (Fe(2+)) Permease (ZIP) Family ;
Tissue Specificity Expressed in brain and eye.
Function This transporter mediates the influx of zinc.
Endogenous Substrate(s) Zn2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Zinc transporter ZIP12
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Zinc transporter ZIP12
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Zinc transporter ZIP12
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Zinc transporter ZIP12
Microbiota Influence (MBI)

(β) Post-translational Modification of Zinc transporter ZIP12
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Zinc transporter ZIP12
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Zinc transporter ZIP12
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Zinc transporter ZIP12
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Zinc transporter ZIP12
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Zinc salts
 Preclinical Drug Info Arthritis FA5Z [1]
References
1 The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature. 2015 Aug 20;524(7565):356-60.

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