Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0340 Transporter Info
Gene Name	SLC39A12
Transporter Name	Zinc transporter ZIP12
Gene ID	221074
UniProt ID	Q504Y0

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene results in decreased methylation of SLC39A12 5' UTR		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC39A12 promoter		[1]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC39A12 gene		[2]
Regulation Mechanism			Transcription Factor Info
Zinc	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC39A12 protein results in increased transport of Zinc		[3]
Regulation Mechanism			Transcription Factor Info

References
1	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
2	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
3	Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008;49(3):1221-31.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.