Drug Transporter (DT) Information

General Information of DT
DT ID DTD0035
Gene Name SLC30A8
Protein Name Zinc transporter 8
Gene ID
169026
UniProt ID
Q8IWU4
TCDB ID
2.A.4.3.5
3D Structure

Crystal Structure

Crystallisation Method:EM

PDB ID:6XPE

Corresponding Chain:A/B

Sequence Length:50-369

Detail: Struture Info

Synonyms SLC30A8; Solute carrier family 30 member 8; ZNT8; ZnT-8
DT Family Cation Diffusion Facilitator (CDF) Family ;
Tissue Specificity In the endocrine pancreas, expressed ininsulin-producing beta cells. Expressed at relatively high levelsin subcutaneous fat tissue from lean persons; much lower levels invisceral fat, whether from lean or obese individuals, and insubcutaneous fat tissue from obese individuals. Expressed inperipheral blood mononuclear cells, including T-cells and B-cells,with great variation among individuals ranging from negative tostrongly positive.
Function This transporter may be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter.
Endogenous Substrate(s) Zn2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Zinc transporter 8
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Zinc transporter 8
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Zinc transporter 8
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Zinc transporter 8
Microbiota Influence (MBI)

(β) Post-translational Modification of Zinc transporter 8
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Zinc transporter 8
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Zinc transporter 8
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Zinc transporter 8
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Zinc transporter 8
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Zinc transporter 8
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Zinc salts
 Preclinical Drug Info Arthritis FA5Z [1]
References
1 Zinc transporter 8 (ZnT8) and cell function. Trends Endocrinol Metab. 2014 Aug;25(8):415-24.

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