Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0035 Transporter Info
Gene Name SLC30A8
Transporter Name Zinc transporter 8
Gene ID
169026
UniProt ID
Q8IWU4

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        JUN 

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       Transcriptional Phenomenon1

 Binding to SLC30A8 gene in K562 cells [1]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC30A8 gene in K562 cells, which leads to an affected expression of the drug transporter Zinc transporter 8.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Direct binding to SLC30A8 gene in prostate cancer condition [2]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC30A8 gene in prostate cancer condition, which leads to a affected expression of the drug transporter Zinc transporter 8.

       Transcriptional Phenomenon2

 Direct binding to SLC30A8 gene [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC30A8 gene in . condition, which leads to a affected expression of the drug transporter Zinc transporter 8.

      Class2.3: C2H2 zinc finger factors

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        KLF5 

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       Transcriptional Phenomenon1

 Activation of SLC30A8 gene in gastric cancer condition [4]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Affected Drug/Substrate

 Metformin

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC30A8 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Zinc transporter 8.

        WT1 

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       Transcriptional Phenomenon1

 Activation of SLC30A8 gene in podocyte condition [5]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC30A8 gene in podocyte condition, which leads to an increased expression of the drug transporter Zinc transporter 8.

        ZNF217 

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       Transcriptional Phenomenon1

 Binding to SLC30A8 gene in breast cancer condition [6]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC30A8 gene in breast cancer condition, which leads to an affected expression of the drug transporter Zinc transporter 8.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        PDX1 

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       Transcriptional Phenomenon1

 Repression of SLC30A8 gene in diabetes mellitus condition [7]

TF Protein Name

 Pancreas/duodenum homeobox protein 1 Transcription Factor Info

Studied Phenotype

 Diabetes mellitus [ICD11: 5A10-5A14]

Tissue

 Pancreas

Related DT Changes

 Down regulating

Experimental Material

 CD-1 mice

Detailed Description

 Pancreas/duodenum homeobox protein 1 (PDX1) has been reported to repress the transcription of SLC30A8 gene in diabetes mellitus condition, which leads to a decreased expression of the drug transporter Zinc transporter 8.

      Class3.2: Paired box factors

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        PAX6 

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       Transcriptional Phenomenon1

 Repression of SLC30A8 gene in diabetes mellitus condition [8]

TF Protein Name

 Paired box protein Pax-6 Transcription Factor Info

Affected Drug/Substrate

 Insulin

Studied Phenotype

 Diabetes mellitus [ICD11: 5A10-5A14]

Tissue

 Pancreas

Related DT Changes

 Down regulating

Experimental Material

 Pax6 KO mice

Detailed Description

 Paired box protein Pax-6 (PAX6) has been reported to repress the transcription of SLC30A8 gene in diabetes mellitus condition, which leads to a decreased expression of the drug transporter Zinc transporter 8.

      Class3.3: Fork head / winged helix factors

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        FOXA1 

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       Transcriptional Phenomenon1

 Binding to SLC30A8 gene in prostate cancer condition [2]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC30A8 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Zinc transporter 8.

      Class3.5: Tryptophan cluster factors

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        ERG 

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       Transcriptional Phenomenon1

 Binding to SLC30A8 gene in oncogenesis condition [3]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional regulator ERG (ERG) has been reported to bind to the transcription of SLC30A8 gene in oncogenesis condition, which leads to an affected expression of the drug transporter Zinc transporter 8.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        RBPJ 

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       Transcriptional Phenomenon1

 Binding to SLC30A8 gene in immortal lymphoblast cell lines (LCLs) condition [9]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC30A8 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Zinc transporter 8.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Binding to SLC30A8 gene in epithelial ovarian cancer condition [10]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC30A8 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Zinc transporter 8.
References
1 c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
2 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
3 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
4 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
5 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
6 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
7 The pancreatic islet beta-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. Biochem J. 2011 Jan 1;433(1):95-105.
8 The transcription factor Pax6 is required for pancreatic beta cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice. J Biol Chem. 2017 May 26;292(21):8892-8906.
9 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
10 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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