General Information of Drug Transporter (DT)
DT ID DTD0035 Transporter Info
Gene Name SLC30A8
Protein Name Zinc transporter 8
Gene ID
169026
UniProt ID
Q8IWU4
3D Structure

Crystal Structure of This DT

Crystallisation Method:EM

PDB ID:6XPE

Corresponding Chain:A/B

Sequence Length:50-369

Detail: Struture Info

Inter-species Structural Differences (ISD)
Mus musculus (Mouse)
        Gene Name Slc30a8
        UniProt ID
Q8BGG0
        UniProt Entry
ZNT8_MOUSE
        3D Structure

Method:Homology modeling

Teplate PDB:6XPE_A

Sequence Length:319

Identity:81.25%

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        Performance Minimized Score -743.744 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-0.86 ±0.41

Residues in Favored Region:307

Ramachandran favored:96.85%

Number of Outliers:2

Ramachandran outliers:0.63%

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        Local Quality

QMEANBrane Score:0.79

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Rattus norvegicus (Rat)
        Gene Name Slc30a8
        UniProt ID
P0CE46
        UniProt Entry
ZNT8_RAT
        3D Structure

Method:Homology modeling

Teplate PDB:6XPE_A

Sequence Length:320

Identity:79.375%

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        Performance Minimized Score -796.013 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-0.55 ±0.44

Residues in Favored Region:305

Ramachandran favored:95.91%

Number of Outliers:2

Ramachandran outliers:0.63%

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        Local Quality

QMEANBrane Score:0.79

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Xenopus laevis (African clawed frog)
        Gene Name slc30a8
        UniProt ID
Q5I020
        UniProt Entry
ZNT8_XENLA
        3D Structure

Method:Homology modeling

Teplate PDB:6XPE_A

Sequence Length:329

Identity:61.094%

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        Performance Minimized Score -745.573 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-1.48 ±0.41

Residues in Favored Region:312

Ramachandran favored:95.41%

Number of Outliers:4

Ramachandran outliers:1.22%

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        Local Quality

QMEANBrane Score:0.79

Click to Save Local Quality Plot in PNG Format
References
1 Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn(2+)-releasing mechanism. J Struct Biol. 2023;215(1):107926.

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