| General Information of DT | |||||
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| DT ID | DTD0483 | ||||
| Gene Name | SLC9A3 | ||||
| Protein Name | Sodium/hydrogen exchanger 3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:2MDF_A; 4CZB_A Identity:81.633%;34.483% Minimized Score:-92.234 kcal/mol Detail: Structure Info |
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| Synonyms | DIAR8; NHE-3; NHE3; Na(+)/H(+) exchanger 3; SLC9A3; Solute carrier family 9 member 3 | ||||
| DT Family | Monovalent Cation:Proton Antiporter-1 (CPA1) family ; | ||||
| Function | This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions. Plays an important role in signal transduction. | ||||
| Endogenous Substrate(s) | Na+; H+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium/hydrogen exchanger 3 |
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(β) Cell Distribution Level of Sodium/hydrogen exchanger 3 |
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(γ) Organelle Distribution Level of Sodium/hydrogen exchanger 3 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Sodium/hydrogen exchanger 3 |
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(β) Post-translational Modification of Sodium/hydrogen exchanger 3 |
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(γ) Transcriptional Regulation of Sodium/hydrogen exchanger 3 |
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(δ) Epigenetic Regulation of Sodium/hydrogen exchanger 3 |
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(ε) Exogenous Modulation of Sodium/hydrogen exchanger 3 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium/hydrogen exchanger 3 |
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(β) Disease-specific Protein Abundances of Sodium/hydrogen exchanger 3 |
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(γ) Species- and Tissue-specific DT Abundances |
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