Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0483 Transporter Info
Gene Name SLC9A3
Transporter Name Sodium/hydrogen exchanger 3
Gene ID
6550
UniProt ID
P48764

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPB 

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       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast; Cervix; Colon; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

      Class1.2: Basic helix-loop-helix factors

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        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [2]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

        BHLHE40 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [3]

TF Protein Name

 Class E basic helix-loop-helix protein 40 Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A3 gene in melanoma condition [4]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC9A3 gene in melanoma condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 3.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [5]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        PPARG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A3 gene in type 2 diabetes condition [6]

TF Protein Name

 Peroxisome proliferator-activated receptor gamma Transcription Factor Info

Studied Phenotype

 Type 2 diabetes [ICD11: 5A11]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 human type 2 diabetes kidney cortex isolates

Detailed Description

 Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of SLC9A3 gene in type 2 diabetes condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 3.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A3 gene in THP-1 human monocytic leukemia cells condition [7]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC9A3 gene in THP-1 human monocytic leukemia cells condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 3.

      Class2.2: Other C4 zinc finger-type factors

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        GATA3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A3 gene in breast cancer condition [8]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC9A3 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 3.

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A3 gene in gastric cancer condition [9]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to bind to the transcription of SLC9A3 gene in gastric cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 3.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A3 gene in colon cancer condition [10]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Affected Drug/Substrate

 Para-Methoxyamphetamine

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (C2bbe1)

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to activate the transcription of SLC9A3 gene in colon cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 3.

       Transcriptional Phenomenon2

 Binding to SLC9A3 gene in erythroleukemia condition [11]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC9A3 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 3.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [5]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [3]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

        SP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A3 gene in colon cancer condition [10]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Affected Drug/Substrate

 Para-Methoxyamphetamine

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (C2bbe1)

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC9A3 gene in colon cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 3.

        SP3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A3 gene in colon cancer condition [10]

TF Protein Name

 Transcription factor Sp3 Transcription Factor Info

Affected Drug/Substrate

 Para-Methoxyamphetamine

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (C2bbe1)

Detailed Description

 Transcription factor Sp3 (SP3) has been reported to activate the transcription of SLC9A3 gene in colon cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 3.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [2]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        ZEB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [2]

TF Protein Name

 Zinc finger E-box-binding homeobox 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

      Class3.3: Fork head / winged helix factors

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        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A3 gene in prostate cancer condition [12]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC9A3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 3.

        FOXM1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A3 gene in breast cancer condition [13]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC9A3 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 3.

      Class3.5: Tryptophan cluster factors

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        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A3 gene [1]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC9A3 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 3.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        RBPJ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A3 gene in immortal lymphoblast cell lines condition [14]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC9A3 gene in immortal lymphoblast cell lines condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 3.

      Class6.2: STAT domain factors

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        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A3 gene in health condition [15]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Madin-Darby canine kidney cells (MDCK)

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC9A3 gene in health condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 3.

      Class6.3: p53 domain factors

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        TP53 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A3 gene in health condition [16]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC9A3 gene in health condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 3.

      Class6.4: Runt domain factors

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        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A3 gene in megakaryocytes condition [17]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC9A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 3.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-155. (ID:ENSG00000066230)
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6 The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrol Dial Transplant. 2009 Apr;24(4):1130-41.
7 Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
8 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
9 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
10 Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1. Biochem J. 2006 Jun 1;396(2):327-36.
11 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
12 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
13 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
14 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
15 Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation. Am J Physiol Cell Physiol. 2009 Jan;296(1):C13-24.
16 Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle. 2011;10(24):4237-49.
17 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.

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