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朱峰 - 浙江大学
于导师
朱峰博士

浙江大学教授博士生导师H-index & My Citations (Google Scholar)

中国药理学会分析药理学委员会委员,青年委员会副主任,常务委员;中国化学会计算机化学委员会委员;中国计算机学会生物信息学专业组委员;重庆市生物信息学会副理事长

zhufeng@zju.edu.cn(常用邮箱)prof.zhufeng@gmail.com0571-88208444
研究兴趣
药物化学药物设计新药靶发现生物信息学系统生物学

运用人工智能(机器学习、深度学习)、复杂网络分析等生物信息学手段和组学(蛋白组、代谢组)新技术,分析和发现具有治疗效用药物靶点的成药性和系统生物学特性,发展新颖的用于新药靶发现的预测方法和在线工具,并进一步研究药物与重要靶点的相互作用机制。

学术任职
201811月至今:中国药理学会 分析药理学委员会 委员

201811月至今:中国药理学会 分析药理学青年委员会 副主任,常务委员

201807月至今:浙江大学 竺可桢学院 专业导师

201707月至今:浙江大学 药学院 教授博士生导师

201610月至今:重庆市生物信息学会 副理事长

201606月至今:中国计算机学会 生物信息学专业组 委员

201409月至今:中国化学会 计算机化学专业委员会 委员

201402月至201706月:重庆大学 药学院 教授博士生导师

201207月至201402月:重庆大学 创新药物研究中心 研究员博士生导师

201201月至201207月:新加坡国立大学 药学系 Research Fellow

201101月至201112月:新加坡国立大学 药学系 Research Associate

201007月至201101月:新加坡国立大学 亚洲研究中心和药学系 Research Assistant

教育背景
200608月至201105月:新加坡国立大学 药学系 博士

200308月至200607月:北京师范大学 北京市光学重点实验室 硕士

199908月至200307月:北京师范大学 物理系 学士

奖励荣誉
国家“千人计划”青年项目/青年千人

科技部创新人才推进计划重点领域创新团队核心成员

浙江省“千人计划”创新长期

浙江省高层次人才引进特聘专家

重庆市科学技术奖科技进步一等奖(排名第四)

重庆市高层次人才第二类

唐立新优秀科研教师奖

浙江大学“百人计划”

重庆大学“百人计划”

项目资助
在研项目

201901月开始(项目主持人):国家自然科学基金面上项目(81872798

201809月开始(子课题骨干):国家重点研发计划“精准医学研究”重点专项(2018YFC0910500

201801月开始(项目主持人):浙江大学青年科研创新专项2018QNA7023

201707月开始(项目主持人):浙江大学“百人计划”基金(ZJU2017070

201608月开始(课题负责人):国家重点研发计划“精准医学研究”重点专项(2016YFC0902200

201512月开始(项目主持人):重庆市新药创制(化药类)主题专项cstc2015zdcy-ztzx120003


结题项目

201406月开始(项目主持人):国家“千人计划青年项目IRPC-Y-CQU2014-ZF

201406月开始(项目主持人):中央高校基本科研跨学科重大项目CDJZR14 46 88 01结题优秀

201301月开始(项目主持人):中央高校基本科研跨学科重点项目CQDXWL-2012-Z003结题优秀

201301月开始(项目主持人):国家自然科学基金青年项目(81202459

201209月开始(项目主持人):重庆市自然科学基金cstc2012jjA10116

201207月开始(项目主持人):重庆大学“百人计划”基金(0903005203176考评优秀

代表性文章

    *corresponding author; highlighted graphic abstract

  1. J. Y. Yin, W. Sun, F. C. Li, J. J. Hong, X. X. Li, Y. Zhou, Y. J. Lu, M. Z. Liu, X. Zhang, N. Chen, X. P. Jin, J. Xue, S. Zeng*, L. S. Yu*, F. Zhu*. VARIDT 1.0: variability of drug transporter database. Nucleic Acids Res (当年影响因子: 11.147, 生物一区 TOP 期刊). doi: 10.1093/nar/gkz779 (2019).
  2. Q. X. Yang, B. Li, J. Tang, X. J. Cui, Y. X. Wang, X. F. Li, J. Hu, Y. Z. Chen, W. W. Xue, Y. Lou, Y. Q. Qiu*, F. Zhu*. Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data. Brief Bioinform (当年影响因子: 9.101, 生物一区 TOP 期刊). doi: 10.1093/bib/bbz049 (2019).
  3. Y. H. Li, X. X. Li, J. J. Hong, Y. X. Wang, J. B. Fu, H. Yang, C. Y. Yu, F. C. Li, J. Hu, W. W. Xue, Y. Y. Jiang, Y. Z. Chen*, F. Zhu*. Clinical trials, progression-speed differentiating features, and swiftness rule of the innovative targets of first-in-class drugs. Brief Bioinform (当年影响因子: 9.101, 生物一区 TOP 期刊). doi: 10.1093/bib/bby130 (2019).
  4. J. J. Hong, Y. C. Luo, M. J. Mou, J. B. Fu, Y. Zhang, W. W. Xue, T. Xie, L. Tao*, Y. Lou*, F. Zhu*. Convolutional neural network-based annotation of bacterial type IV secretion system effectors with enhanced accuracy and reduced false discovery. Brief Bioinform (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). doi: 10.1093/bib/bbz120 (2019).
  5. J. Tang, J. B. Fu, Y. X. Wang, B. Li, Y. H. Li, Q. X. Yang, X. J. Cui, J. J. Hong, X. F. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. ANPELA: analysis and performance-assessment of the label-free quantification workflow for metaproteomic studies. Brief Bioinform (当年影响因子: 9.101, 生物一区 TOP 期刊). doi: 10.1093/bib/bby127 (2019).
  6. J. Tang, J. B. Fu, Y. X. Wang, Y. C. Luo, Q. X. Yang, B. Li, G. Tu, J. J. Hong, X. J. Cui, Y. Z. Chen, L. X. Yao, W. W. Xue, F. Zhu*. Simultaneous improvement in the precision, accuracy and robustness of label-free proteome quantification by optimizing data manipulation chains. Mol Cell Proteomics (当年影响因子: 5.236, 生物二区期刊). 18(8): 1683-1699 (2019).
  7. Y. Zhang, J. B. Ying, J. J. Hong, F. C. Li, T. T. Fu, F. Y. Yang, G. X. Zheng, X. J. Yao, Y. Lou, Y. Q. Qiu, W. W. Xue*, F. Zhu*. How does chirality determine the selective inhibition of histone deacetylase 6? A lesson from Trichostatin A enantiomers based on molecular dynamics. ACS Chem Neurosci (当年影响因子: 4.211, 化学二区 TOP 期刊). 10(5): 2467-2480 (2019).
  8. 封面论文:

  9. Q. X. Yang, Y. X. Wang, F. C. Li, S. Zhang, Y. C. Luo, Y. Li, J. Tang, B. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. Identification of the gene signature reflecting schizophrenia's etiology by constructing artificial intelligence-based method of enhanced reproducibility. CNS Neurosci Ther (当年影响因子: 3.394, 医学二区期刊). 25(9): 1054-1063 (2019).
  10. 封面论文:

  11. Y. H. Li, C. Y. Yu, X. X. Li, P. Zhang, J. Tang, Q. X. Yang, T. T. Fu, X. Y. Zhang, X. J. Cui, G. Tu, Y. Zhang, S. Li, F. Y. Yang, Q. Sun, C. Qin, X. Zeng, Z. Chen, Y. Z. Chen*, F. Zhu*. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. Nucleic Acids Res (当年影响因子: 11.561, 生物一区 TOP 期刊). 46(D1): 1121-1127 (2018).
  12. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 0.16% in 2019.
    领域内专家评论:
    • Introduced by OMICTOOLS as "useful for facilitating patient focused research, discovery and clinical investigations of the targeted therapeutics".

  13. F. Zhu*, X. X. Li, S. Y. Yang, Y. Z. Chen*. The clinical success of drug targets prospectively predicted by the in-silico study. Trends Pharmacol Sci (当年影响因子: 12.797, 医学一区 TOP 期刊). 39(3): 229-231 (2018).
  14. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 0.10% in 2019.

  15. W. W. Xue, F. Y. Yang, P. P. Wang, G. X. Zheng, Y. Z. Chen, X. J. Yao, F. Zhu*. What contributes to serotonin-norepinephrine reuptake inhibitors' dual-targeting mechanism? The key role of transmembrane domain 6 in human serotonin and norepinephrine transporters revealed by MD simulation. ACS Chem Neurosci (当年影响因子: 4.211, 化学二区 TOP 期刊). 9(5): 1128-1140 (2018).
  16. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 0.29% in 2019.

  17. F. Y. Yang, G. X. Zheng, T. T. Fu, X. F. Li, G. Tu, Y. H. Li, X. J. Yao, W. W. Xue*, F. Zhu*. Prediction of binding mode and resistance profile for dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase associated ribonuclease H. Phys Chem Chem Phys (当年影响因子: 4.123, 化学二区 TOP 期刊). 20(37): 23873-23884 (2018).
  18. 封底论文:

  19. Z. J. Han, W. W. Xue, L. Tao, F. Zhu*. Identification of novel immune-relevant drug target genes for alzheimer's disease by combining ontology inference with network analysis. CNS Neurosci Ther (当年影响因子: 3.495, 医学二区期刊). 24(12): 1253-1263 (2018).
  20. 封面论文:

  21. B. Li, J. Tang, Q. X. Yang, S. Li, X. J. Cui, Y. H. Li, Y. Z. Chen, W. W. Xue, X. F. Li, F. Zhu*. NOREVA: normalization and evaluation of MS-based metabolomics data. Nucleic Acids Res (当年影响因子: 10.162, 生物一区 TOP 期刊). 45(W1): 162-170 (2017).
  22. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 1.27%% in 2019.
    • The Percentile in Subject Area shown in InCites™ was 2.98% in 2018.
    领域内专家评论:
    • Introduced by OMICTOOLS as "provided valuable guidance to the selection of suitable algorithm in metabolomics".
    • Discussed in StackExchange as "works fine" and "corrections for batches without QC options".

  23. P. P. Wang, X. Y. Zhang, T. T. Fu, S. Li, B. Li, W. W. Xue*, X. J. Yao, Y. Z. Chen, F. Zhu*. Differentiating physicochemical properties between addictive and nonaddictive ADHD drugs revealed by molecular dynamics simulation studies. ACS Chem Neurosci (当年影响因子: 4.348, 化学二区 TOP 期刊). 8(6): 1416-1428 (2017).
  24. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 1.32% in 2019.

  25. H. Yang, C. Qin, Y. H. Li, L. Tao, J. Zhou, C. Y. Yu, F. Xu, Z. Chen, F. Zhu*, Y. Z. Chen*. Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information. Nucleic Acids Res (当年影响因子: 9.202, 生物一区 TOP 期刊). 44(D1): 1069-1074 (2016).
  26. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 0.66% in 2019.
    • The Percentile in Subject Area shown in InCites™ was 0.71% in 2018.
    • The Percentile in Subject Area shown in InCites™ was 0.87% in 2017.

  27. F. Zhu, Z. Shi, C. Qin, L. Tao, X. Liu, F. Xu, L. Zhang, Y. Song, X. H. Liu, J. X. Zhang, B. C. Han, P. Zhang, Y. Z. Chen*. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (当年影响因子: 8.026, 生物一区 TOP 期刊). 40(D1): 1128-1136 (2012).
  28. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 0.60% in 2019.
    • The Percentile in Subject Area shown in InCites™ was 0.62% in 2018.
    • The Percentile in Subject Area shown in InCites™ was 0.31% in 2017.

    领域内专家评论:

    • "FACULTYof1000" as "the top 2% of published articles in biology and medicine" and "a most useful resource for scientists and companies working on drug discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations".
    • Prof. Chris Southan in his blog as "Therapeutic Target Database in PubChem".

  29. F. Zhu, C. Qin, L. Tao, X. Liu, Z. Shi, X. H. Ma, J. Jia, Y. Tan, C. Cui, J. S. Lin, C. Y. Tan, Y. Y. Jiang*, Y. Z. Chen*. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A (当年影响因子: 9.432, 综合性一区 TOP 期刊). 108(31): 12943-12948 (2011).
  30. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 0.94% in 2019.
    • The Percentile in Subject Area shown in InCites™ was 1.16% in 2018.
    • The Percentile in Subject Area shown in InCites™ was 1.91% in 2017.
    领域内专家评论: 科技媒体及新闻报道:

  31. F. Zhu, B. C. Han, P. Kumar, X. H. Liu, X. H. Ma, X. N. Wei, L. Huang, Y. F. Guo, L. Y. Han, C. J. Zheng, Y. Z. Chen*. Update of TTD: therapeutic target database. Nucleic Acids Res (当年影响因子: 7.479, 生物一区 TOP 期刊). 38(D1): 787-791 (2010).
  32. ESI高被引或扩展高被引论文:
    • The Percentile in Subject Area shown in InCites™ was 2.95% in 2017.

  33. F. Zhu, L. Y. Han, C. J. Zheng, B. Xie, M. T. Tammi, S. Y. Yang, Y. Q. Wei, Y. Z. Chen*. What are next generation innovative therapeutic targets? Clues from genetic, structural, physicochemical and system profile of successful targets. J Pharmacol Exp Ther (当年影响因子: 3.867, 医学二区 TOP 期刊). 330(1): 304-315 (2009).
  34. 所构建方法的临床或实验验证:
    • Pasireotide targeting Somatostatin receptor 1 was approved by FDA in 2011.
    • Fingolimod targeting S1P receptor was approved by FDA in 2010.
    • Ecallantide targeting Plasma Kallikrein was approved by FDA in 2009.
    • Cinryze targeting C1 esterase was approved by FDA in 2009.
    • Icatibant targeting BK-2 receptor was approved by FDA in 2008.
    • Plerixafor targeting CXCR4 was approved by FDA in 2008.
承办或(参与)组织的学术会议

    第十五届全国计算机化学学术会议2019)“精准药物设计与精准医学”分会chairman,复旦大学,上海

    第十五届全国计算机化学学术会议2019学术委员会委员,复旦大学,上海

    第四届中国计算机学会生物信息学会议2019)“组学大数据与医疗”分会chairman,华南理工大学,广州

    第四届中国计算机学会生物信息学会议2019程序委员会委员,华南理工大学,广州

    中国化学会第三十一届学术年会2018)第二十四分会103A分会vice-chairman,浙江大学,杭州

    亚洲药学科学联盟二零一七学术会议2017)“代谢组学”分会chairman,厦门大学,厦门

    第十四届全国计算机化学学术会议2017学术委员会委员,南京大学,南京

    第二届中国计算机学会生物信息学会议2017学术委员会委员,中南大学,长沙

    第六届国际药物化学大会2016)“多靶点药物和蛋白-蛋白相互作用”分会chairman,中国药科大学,南京

    第六届国际药物化学大会2016)“药物转运体及药代、药效”分会vice-chairman,中国药科大学,南京

    第二届生物信息学与药物设计研讨会2016大会组委会主席学术委员会委员,重庆大学,重庆

    第十三届全国计算机化学学术会议2015学术委员会委员,中山大学,广州

    首届天然产物合成和药物先进制造方法国际研讨会2012组织委员会委员,重庆大学,重庆

国际国内学术会议邀请报告
杂志评审(按字母顺序排序)
ACS Chem Neurosci; Aging Dis; Amino Acids; Anal Chem; Artif Cells Nanomed Biotechnol; Bioinformatics; BMC Bioinformatics; Brief Bioinform; CNS Neurosci Ther; Curr Pharm Des; Drug Dev Res; Expert Opin Ther Targets; Front Pharmacol; J Chem Inf Model; J Mol Graph Model; J Pharmacol Exp Ther; Med Res Rev; Microb Pathog; Mol Biosyst; Mol Pharmaceut; Mol Pharmacol; Mol Simul; Pharmacol Res; Phys Chem Chem Phys; Nucleic Acids Res; Sci Rep

杂志编委或副主编(按字母顺序排序)
Comput Biol Med; Curr Bioinform; J Alzheimers Dis; Prog Pharm Sci; Protein Pept Lett

IDRB: Innovative Drug Research and Bioinformatics Group


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