Microbe Species Information

General Information of This Microbe species
Species ID	MIC00100
Species Name	Vibrio cholerae
Taxonomy ID	666
Lineage	Kingdom:Bacteria Phylum:Pseudomonadota Class:Gammaproteobacteria Order:Vibrionales Family:Vibrionaceae Genus: Vibrio Species: Vibrio cholerae

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
CACNA1A	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
FLVCR1	Transporter Info	Health [ICD11: N.A]	[5], [6], [7], [8]
IREG1	Transporter Info	Health [ICD11: N.A]	[1], [9], [4]
NaCT	Transporter Info	Health [ICD11: N.A]	[10], [11], [12]
NADC1	Transporter Info	Health [ICD11: N.A]	[10], [11], [12]
NADC3	Transporter Info	Health [ICD11: N.A]	[10], [11], [12]
NAS1	Transporter Info	Health [ICD11: N.A]	[10], [11], [12]
NRAMP2	Transporter Info	Cholera [ICD11: 1A00]	[13], [14], [15]
SLC25A28	Transporter Info	Health [ICD11: N.A]	[1], [9], [4]
SLC25A37	Transporter Info	Health [ICD11: N.A]	[1], [9], [4]
SLC48A1	Transporter Info	Health [ICD11: N.A]	[5], [6], [7], [8]
SLC49A2	Transporter Info	Health [ICD11: N.A]	[5], [6], [7], [8]
SUT1	Transporter Info	Health [ICD11: N.A]	[10], [11], [12]
ZIP1	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP10	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP11	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP12	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP13	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP14	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP2	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP3	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP4	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP5	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP6	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP7	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP8	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
ZIP9	Transporter Info	Cholera [ICD11: 1A00]	[16], [17], [15]
Class3: Microbiota regulating the expression and function of DT via the biotransformation of exogenous substances
SLC9A2	Transporter Info	Health [ICD11: N.A]	[18], [19], [20]
SLC9A3	Transporter Info	Health [ICD11: N.A]	[18], [19], [20]

References
1	Sequestration and scavenging of iron in infection. Infect Immun. 2013 Oct;81(10):3503-14.
2	Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis. J Bacteriol. 1997 Nov;179(22):7055-62.
3	Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence. Front Cell Infect Microbiol. 2013 Dec 5;3:90.
4	Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
5	Iron metabolism in pathogenic bacteria. Annu Rev Microbiol. 2000;54:881-941.
6	Iron-regulated hemolysin production and utilization of heme and hemoglobin by Vibrio cholerae. Infect Immun. 1988 Nov;56(11):2891-5.
7	Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res. 2016 Jun 21;49(6):1104-10.
8	Handling heme: The mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019 Mar;133:88-100.
9	Characterization of ferric and ferrous iron transport systems in Vibrio cholerae. J Bacteriol. 2006 Sep;188(18):6515-23.
10	Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter. Nature. 2012 Nov 22;491(7425):622-6.
11	Structure and function of the divalent anion/Na+ symporter from Vibrio cholerae and a humanized variant. Nat Commun. 2017 Apr 24;8:15009.
12	Functional characterization of a Na+-dependent dicarboxylate transporter from Vibrio cholerae. J Gen Physiol. 2014 Jun;143(6):745-59.
13	Manganese transport and the role of manganese in virulence. Annu Rev Microbiol. 2006;60:187-209.
14	A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3449-54.
15	Dual Zinc Transporter Systems in Vibrio cholerae Promote Competitive Advantages over Gut Microbiome. Infect Immun. 2015 Oct;83(10):3902-8.
16	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
17	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.
18	The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018 Mar 5;6(1):33-45.
19	Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea. Nat Rev Microbiol. 2009 Feb;7(2):110-9.
20	Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G857-63.

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