Drug Transporter (DT) Information

General Information of DT
DT ID DTD0093
Gene Name SLC13A3
Protein Name Sodium/dicarboxylate cotransporter 3
Gene ID
64849
UniProt ID
Q8WWT9
TCDB ID
2.A.47.1.15
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5ULD_A; 5UL7_A

Identity:32.911%;32.41%

Minimized Score:-1021.916 kcal/mol

Detail: Structure Info

Synonyms ARLIAK; NADC3; Na(+)/dicarboxylate cotransporter 3; NaDC-3; SDCT2; SLC13A3; Solute carrier family 13 member 3; hNaDC3; Sodium-dependent high-affinity dicarboxylate transporter 2
DT Family Divalent Anion:Na(+) Symporter (DASS) Family ;
Tissue Specificity Expression is highest in kidney. Detected inplacenta, brain, liver and pancreas.
Function This sodium-dicarboxylate cotransporter can mediates the transport of succinate and other Krebs cycle intermediates.
Endogenous Substrate(s) Dicarboxylates; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/dicarboxylate cotransporter 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/dicarboxylate cotransporter 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/dicarboxylate cotransporter 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium/dicarboxylate cotransporter 3
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium/dicarboxylate cotransporter 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/dicarboxylate cotransporter 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/dicarboxylate cotransporter 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/dicarboxylate cotransporter 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/dicarboxylate cotransporter 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/dicarboxylate cotransporter 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Drug-DT Affinity Assessed by Cell Line

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           6 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Alpha-ketoglutaric acid Investigative Drug Info HEK293T cells-NADC3 Km =149 microM [1]
Alpha-ketoglutaric acid Investigative Drug Info HEK293T cells-NADC3 Km =149 microM [1]
Alpha-ketoglutaric acid Investigative Drug Info HEK293T cells-NADC3 Km =149 microM [1]
Alpha-ketoglutaric acid Investigative Drug Info HEK293T cells-NADC3 Km =149 microM [1]
Succinate Investigative Drug Info HEK293T cells-NADC3 Km =112 microM [1]
Succinate Investigative Drug Info HEK293T cells-NADC3 Km =112 microM [1]
References
1 SLC13A3 variants cause acute reversible leukoencephalopathy and -ketoglutarate accumulation. Ann Neurol. 2019 Mar;85(3):385-395.

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