Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0093 Transporter Info | |||||
| Gene Name | SLC13A3 | |||||
| Transporter Name | Sodium/dicarboxylate cotransporter 3 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 5ULD_A; 5UL7_A | Identity | 32.911; 32.41% | |||
| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -1.85 ±0.33 | |||||
| Residues in Favored Region | 515 | Ramachandran favored | 93.64% | |||
| Number of Outliers | 5 | Ramachandran outliers | 0.91% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.76 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8UVC | EM | 2.09 Å | Trichoplusia ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1-602 | Mutation | No | |||
| 8UVC | EM | 2.09 Å | Trichoplusia Ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1-602 | Mutation | No | |||
| 8UVD | EM | 2.16 Å | Trichoplusia ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1-602 | Mutation | No | |||
| 8UVD | EM | 2.16 Å | Trichoplusia Ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1-602 | Mutation | No | |||
| 8UVE | EM | 2.6 Å | Trichoplusia ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1-602 | Mutation | No | |||
| 8UVE | EM | 2.6 Å | Trichoplusia Ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1-602 | Mutation | No | |||
| 8UVF | EM | 2.17 Å | Trichoplusia ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1-602 | Mutation | No | |||
| 8UVF | EM | 2.17 Å | Trichoplusia Ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1-602 | Mutation | No | |||
| References | ||||||
| 1 | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3. Nat Struct Mol Biol. 2025 Mar;32(3):502-512. | |||||
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