Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0093 Transporter Info
Gene Name	SLC13A3
Transporter Name	Sodium/dicarboxylate cotransporter 3
Gene ID	64849
UniProt ID	Q8WWT9

Post-Translational Modification of This DT
Overview ofSLC13A3 Modification Sites with Functional and Structural Information
Sequence	M A A L A A A A K K V W S A R R L L V L L F T P L A L L P V V F A L P P K E G R C L F V I L L M A V Y W C T E A L P L S V T A L L P I V L F P F M G I L P S N K V C P Q Y F L D T N F L F L S G L I M A S A I E E W N L H R R I A L K I L M L V G V Q P A R L I L G M M V T T S F L S M W L S N T A S T A M M L P I A N A I L K S L F G Q K E V R K D P S Q E S E E N T A A V R R N G L H T V P T E M Q F L A S T E A K D H P G E T E V P L D L P A D S R K E D E Y R R N I W K G F L I S I P Y S A S I G G T A T L T G T A P N L I L L G Q L K S F F P Q C D V V N F G S W F I F A F P L M L L F L L A G W L W I S F L Y G G L S F R G W R K N K S E I R T N A E D R A R A V I R E E Y Q N L G P I K F A E Q A V F I L F C M F A I L L F T R D P K F I P G W A S L F N P G F L S D A V T G V A I V T I L F F F P S Q R P S L K W W F D F K A P N T E T E P L L T W K K A Q E T V P W N I I L L L G G G F A M A K G C E E S G L S V W I G G Q L H P L E N V P P A L A V L L I T V V I A F F T E F A S N T A T I I I F L P V L A E L A I R L R V H P L Y L M I P G T V G C S F A F M L P V S T P P N S I A F A S G H L L V K D M V R T G L L M N L M G V L L L S L A M N T W A Q T I F Q L G T F P D W A D M Y S V N V T A L P P T L A N D T F R T L
PTM type	X-Acetylation X-N-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC13A3			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC13A3 Lysine 9 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC13A3			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	586
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC13A3 Asparagine 586 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC13A3			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	596
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC13A3 Asparagine 596 has the potential to affect its expression or activity.
Phosphorylation
Serine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC13A3			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	60
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Serine 60 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC13A3			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	78
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Serine 78 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC13A3			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	173
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Serine 173 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC13A3			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Serine 176 has the potential to affect its expression or activity.
Threonine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC13A3			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	54
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Threonine 54 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC13A3			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	62
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Threonine 62 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC13A3			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	180
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Threonine 180 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC13A3			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	190
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Threonine 190 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC13A3			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	193
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Threonine 193 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC13A3			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	51
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A3 Tyrosine 51 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[7]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	170
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC13A3 Lysine 170 has the potential to affect its expression or activity.

References
1	Fitting the Nucleus-22 cochlear implant for Spanish speakers. Ann Otol Rhinol Laryngol Suppl. 1995 Sep;166:75-6.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S13A3_HUMAN)
3	In situ sample processing approach (iSPA) for comprehensive quantitative phosphoproteome analysis. J Proteome Res. 2014 Sep 5;13(9):3896-904.
4	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
5	Integrated Proteomics Reveals Apoptosis-related Mechanisms Associated with Placental Malaria. Mol Cell Proteomics. 2019 Feb;18(2):182-199.
6	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
7	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.

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Detail Information of Post-Translational Modifications

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