Microbe Species Information

General Information of This Microbe species
Species ID	MIC00068
Species Name	Salmonella enterica
Taxonomy ID	28901
Lineage	Kingdom:Bacteria Phylum:Pseudomonadota Class:Gammaproteobacteria Order:Enterobacterales Family:Enterobacteriaceae Genus: Salmonella Species: Salmonella enterica

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
CACNA1A	Transporter Info	Health [ICD11: N.A]	[1], [2], [3]
IREG1	Transporter Info	Health [ICD11: N.A]	[3], [4], [5]
NRAMP2	Transporter Info	Health [ICD11: N.A]	[1], [2], [3]
P-GP	Transporter Info	Health [ICD11: N.A]	[6]
SLC11A1	Transporter Info	Health [ICD11: N.A]	[7], [8], [9], [10]
SLC25A28	Transporter Info	Health [ICD11: N.A]	[1], [2], [3]
SLC25A37	Transporter Info	Health [ICD11: N.A]	[1], [2], [3]
SLC41A1	Transporter Info	Health [ICD11: N.A]	[11], [12], [13], [14], [15]
SLC58A1	Transporter Info	Health [ICD11: N.A]	[11], [12], [13], [14], [15]
ZIP1	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP10	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP11	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP12	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP13	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP14	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP2	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP3	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP4	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP5	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP6	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP7	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP8	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZIP9	Transporter Info	Colon cancer [ICD11: 2B90]	[4], [16], [17]
ZNT1	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT10	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT2	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT3	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT4	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT5	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT6	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT7	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT8	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
ZNT9	Transporter Info	Acute monocytic leukemia [ICD11: 2A60.34]	[4], [18], [16], [19]
Class3: Microbiota regulating the expression and function of DT via the biotransformation of exogenous substances
ABCC7	Transporter Info	Typhoid fever [ICD11: 1A07]	[20], [21]
Class4: Microbiota regulating the expression and function of DT via other mechanisms
NKCC1	Transporter Info	Diarrhea associated with infection by invasive enteric pathogens [ICD11: 1A03]	[22], [23]

Species Relative Abundances of This Microbe species

References
1	Iron metabolism in pathogenic bacteria. Annu Rev Microbiol. 2000;54:881-941.
2	Ferrioxamine-mediated Iron(III) utilization by Salmonella enterica. Appl Environ Microbiol. 1999 Apr;65(4):1610-8.
3	Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
4	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
5	Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium. Mol Microbiol. 2008 Mar;67(5):971-83.
6	Clinical isolate of a porinless Salmonella typhi resistant to high levels of chloramphenicol. Antimicrob Agents Chemother. 1990 Sep;34(9):1715-9.
7	Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
8	MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infect Immun. 2013 Sep;81(9):3395-405.
9	Human iron transporters. Genes Nutr. 2011 Feb;6(1):45-54.
10	Iron transport machinery of human cells: players and their interactions. Curr Top Membr. 2012;69:67-93.
11	Transport of magnesium by a bacterial Nramp-related gene. PLoS Genet. 2014 Jun 26;10(6):e1004429.
12	Microbial magnesium transport: unusual transporters searching for identity. Mol Microbiol. 1998 Apr;28(2):217-26.
13	Magnesium transport in Salmonella typhimurium: 28Mg2+ transport by the CorA, MgtA, and MgtB systems. J Bacteriol. 1989 Sep;171(9):4761-6.
14	The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):620-8.
15	The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. J Biol Chem. 1999 Jul 16;274(29):20438-43.
16	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.
17	Salmonella enterica serovar Typhimurium growth is inhibited by the concomitant binding of Zn(II) and a pyrrolyl-hydroxamate to ZnuA, the soluble component of the ZnuABC transporter. Biochim Biophys Acta. 2016 Mar;1860(3):534-41.
18	Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Arch Biochem Biophys. 2016 Dec 1;611:66-78.
19	Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. FASEB J. 2016 May;30(5):1901-12.
20	The interaction of gut microbes with host ABC transporters. Gut Microbes. 2010 Sep;1(5):301-306.
21	Salmonella enterica serovar typhi modulates cell surface expression of its receptor, the cystic fibrosis transmembrane conductance regulator, on the intestinal epithelium. Infect Immun. 2002 Nov;70(11):6416-23.
22	The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018 Mar 5;6(1):33-45.
23	Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. Gastroenterology. 2002 Apr;122(4):1070-87.

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