Microbe Species Information

General Information of This Microbe species
Species ID	MIC00074
Species Name	Staphylococcus aureus
Taxonomy ID	1280
Lineage	Kingdom:Bacteria Phylum:Bacillota Class:Bacilli Order:Bacillales Family:Staphylococcaceae Genus: Staphylococcus Species: Staphylococcus aureus

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
CACNA1A	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
COPT2	Transporter Info	Health [ICD11: N.A]	[5], [6], [7], [8]
CTR1	Transporter Info	Health [ICD11: N.A]	[5], [6], [7], [8]
FLVCR1	Transporter Info	Health [ICD11: N.A]	[9], [10], [11], [12]
IREG1	Transporter Info	Health [ICD11: N.A]	[9], [13], [4]
NADC1	Transporter Info	Health [ICD11: N.A]	[14]
NADC3	Transporter Info	Health [ICD11: N.A]	[14]
NRAMP2	Transporter Info	Health [ICD11: N.A]	[9], [13], [4]
SLC11A1	Transporter Info	Health [ICD11: N.A]	[15], [16], [17], [18]
SLC25A28	Transporter Info	Health [ICD11: N.A]	[9], [13], [4]
SLC25A37	Transporter Info	Health [ICD11: N.A]	[9], [13], [4]
SLC48A1	Transporter Info	Health [ICD11: N.A]	[9], [10], [11], [12]
SLC49A2	Transporter Info	Health [ICD11: N.A]	[9], [10], [11], [12]
ZIP1	Transporter Info	Health [ICD11: N.A]	[5], [7], [19], [20]
ZIP10	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP11	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP12	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP13	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP14	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
ZIP2	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP3	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP4	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP5	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP6	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP7	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]
ZIP8	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
ZIP9	Transporter Info	Health [ICD11: N.A]	[19], [20], [21], [22], [23]

Species Relative Abundances of This Microbe species

References
1	Iron metabolism in pathogenic bacteria. Annu Rev Microbiol. 2000;54:881-941.
2	Siderophore production by Staphylococcus aureus and identification of iron-regulated proteins. Infect Immun. 1997 May;65(5):1944-8.
3	Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence. Front Cell Infect Microbiol. 2013 Dec 5;3:90.
4	Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
5	The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota. Nat Rev Microbiol. 2017 Oct 12;15(11):675-687.
6	Cu Homeostasis in Bacteria: The Ins and Outs. Membranes (Basel). 2020 Sep 18;10(9):242.
7	Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus. Science. 2016 May 27;352(6289):1105-9.
8	Human copper transporters: mechanism, role in human diseases and therapeutic potential. Future Med Chem. 2009 Sep;1(6):1125-42.
9	Siderophore-mediated iron acquisition in the staphylococci. J Inorg Biochem. 2010 Mar;104(3):282-8.
10	Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophore. Infect Immun. 2004 Jan;72(1):29-37.
11	Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res. 2016 Jun 21;49(6):1104-10.
12	Handling heme: The mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019 Mar;133:88-100.
13	FhuD1, a ferric hydroxamate-binding lipoprotein in Staphylococcus aureus: a case of gene duplication and lateral transfer. J Biol Chem. 2004 Dec 17;279(51):53152-9.
14	Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2005 Aug;187(15):5189-94.
15	Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
16	MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infect Immun. 2013 Sep;81(9):3395-405.
17	Human iron transporters. Genes Nutr. 2011 Feb;6(1):45-54.
18	Iron transport machinery of human cells: players and their interactions. Curr Top Membr. 2012;69:67-93.
19	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
20	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.
21	Competitors versus Collaborators: Micronutrient Processing by Pathogenic and Commensal Human-Associated Gut Bacteria. Mol Cell. 2020 May 21;78(4):570-576.
22	Bacterial Strategies to Maintain Zinc Metallostasis at the Host-Pathogen Interface. J Biol Chem. 2016 Sep 30;291(40):20858-20868.
23	A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins. J Mol Biol. 2003 Oct 31;333(4):683-95.

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