Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0353 Transporter Info
Gene Name SLC40A1
Transporter Name Iron-regulated transporter 1
Gene ID
30061
UniProt ID
Q9NP59
Microbiota Influence of This DT (MBI)

Bacteria: Actinomycetota

   Genus: Mycobacterium

     Mycobacterium tuberculosis 

Microbe Info

Click to Show/Hide the Full List 8 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [2], [3], [4]

Regulating Factor
Desferriexochelin 772MS

Detailed Description

 The compound Desferriexochelin 772MS Secreted by Mycobacterium tuberculosis str. Erdman has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4]

Regulating Factor
desA1

Detailed Description

 The protein desA1 of Mycobacterium tuberculosis H37Ra has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4]

Regulating Factor
GAPDH

Detailed Description

 The protein GAPDH of Mycobacterium tuberculosis H37Ra has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence4

 Co-transport of human SLC40A1 substrates/drugs in the health condition [1], [5], [4]

Regulating Factor
IrtAB ,

Detailed Description

 The protein IrtAB of Mycobacterium tuberculosis H37Rv has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence5

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4]

Regulating Factor
Rv0641

Detailed Description

 The protein Rv0641 of Mycobacterium tuberculosis H37Ra has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence6

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4]

Regulating Factor
Rv0704

Detailed Description

 The protein Rv0704 of Mycobacterium tuberculosis H37Ra has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence7

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4]

Regulating Factor
Rv1872c

Detailed Description

 The protein Rv1872c of Mycobacterium tuberculosis H37Ra has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence8

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4]

Regulating Factor
tuf

Detailed Description

 The protein tuf of Mycobacterium tuberculosis H37Ra has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

Bacteria: Bacillota

   Genus: Limosilactobacillus

     Limosilactobacillus reuteri 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Down regulating of SLC40A1 expression in conventional mice compared with germ-free mice [6], [7]

Regulating Factor
1,3-Diaminopropane

Regulation Mechanism

 via suppression of Endothelial PAS domain-containing protein 1 (EPAS1) Transcription Factor Info

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Duodenum

In Vivo Model

 C57BL/6 germ-free mice

In Vitro Model

 Human colon carcinoma cells (HCT-116)

Detailed Description

 The compound 1,3-Diaminopropane Generated by Limosilactobacillus reuteri MM4-1A has been reported to decrease the expression of the drug transporter SLC40A1.

       Microbe Influence2

 Down regulating of SLC40A1 expression in conventional mice compared with germ-free mice [6], [7]

Regulating Factor
3-Hydroxypropanal

Regulation Mechanism

 via suppression of Endothelial PAS domain-containing protein 1 (EPAS1) Transcription Factor Info

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Duodenum

In Vivo Model

 C57BL/6 germ-free mice

In Vitro Model

 Human colon carcinoma cells (HCT-116)

Detailed Description

 The compound 3-Hydroxypropanal Generated by Limosilactobacillus reuteri MM4-1A has been reported to decrease the expression of the drug transporter SLC40A1.

   Genus: Staphylococcus

     Staphylococcus aureus 

Microbe Info

Click to Show/Hide the Full List 12 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [8], [9], [4]

Regulating Factor
FhuCBG , ,

Detailed Description

 The protein FhuCBG of Staphylococcus aureus RN6390 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [8], [9], [4]

Regulating Factor
fhuD1

Detailed Description

 The protein fhuD1 of Staphylococcus aureus RN6390 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Sequestration of human SLC40A1 substrates/drugs in the health condition [8], [9], [4]

Regulating Factor
fhud2

Detailed Description

 The protein fhud2 of Staphylococcus aureus RN6390 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence4

 Sequestration of human SLC40A1 substrates/drugs in the health condition [10], [11], [4]

Regulating Factor
fhud2

Detailed Description

 The protein fhud2 of Staphylococcus aureus RN2564 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence5

 Co-transport of human SLC40A1 substrates/drugs in the health condition [3], [4], [8], [12]

Regulating Factor
HtsABC , ,

Detailed Description

 The protein HtsABC of Staphylococcus aureus RN6390 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence6

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [13]

Regulating Factor
isdA

Detailed Description

 The protein isdA of Staphylococcus aureus RN6390 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence7

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [14]

Regulating Factor
isdA

Detailed Description

 The protein isdA of Staphylococcus aureus BB has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence8

 Sequestration of human SLC40A1 substrates/drugs in the health condition [3], [4], [15], [16]

Regulating Factor
isdA

Detailed Description

 The protein isdA of Staphylococcus aureus N100 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence9

 Co-transport of human SLC40A1 substrates/drugs in the health condition [4], [17], [18], [19]

Regulating Factor
MntABC , ,

Detailed Description

 The protein MntABC of Staphylococcus aureus subsp. aureus NCTC 8325 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence10

 Sequestration of human SLC40A1 substrates/drugs in the health condition [3], [4], [8], [12]

Regulating Factor
SfaABC , ,

Detailed Description

 The protein SfaABC of Staphylococcus aureus RN6390 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence11

 Co-transport of human SLC40A1 substrates/drugs in the health condition [3], [4], [8], [20]

Regulating Factor
SirABC , ,

Detailed Description

 The protein SirABC of Staphylococcus aureus subsp. aureus RN4220 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence12

 Co-transport of human SLC40A1 substrates/drugs in the health condition [3], [4], [8], [21]

Regulating Factor
SstABCD , , ,

Detailed Description

 The protein SstABCD of Staphylococcus aureus W has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

     Staphylococcus epidermidis 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [14]

Regulating Factor
Tpn

Detailed Description

 The protein tpn of Staphylococcus epidermidis 138 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [3], [4], [15], [16]

Regulating Factor
Tpn

Detailed Description

 The protein tpn of Staphylococcus epidermidis 2 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

   Genus: Streptococcus

     Streptococcus agalactiae 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [22], [4]

Regulating Factor
FhuCDB , ,

Detailed Description

 The protein FhuCDB of Streptococcus agalactiae A909 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

     Streptococcus equi 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in upper and lower airway disease condition [23], [24], [4]

Regulating Factor
mtsB

Studied Phenotype

 Upper and lower airway disease [ICD11: CA22]

Studied Tissue

 Lung

In Vivo Model

 Swiss Webster mice

Detailed Description

 The protein mtsB of Streptococcus equi subsp. equi NCTC 9682 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [23], [24], [4]

Regulating Factor
mtsB

Detailed Description

 The protein mtsB of Streptococcus equi subsp. zooepidemicus NCTC 7023T has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

Bacteria: Campylobacterota

   Genus: Campylobacter

     Campylobacter coli 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [3], [4], [25], [26], [27]

Regulating Factor
cfrB

Detailed Description

 The protein cfrB of Campylobacter coli W13A has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

     Campylobacter jejuni 

Microbe Info

Click to Show/Hide the Full List 5 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [3], [4], [25], [26], [28]

Regulating Factor
cfrA

Detailed Description

 The protein cfrA of Campylobacter jejuni subsp. jejuni NCTC 11168 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [3], [4], [25], [26], [27]

Regulating Factor
cfrB

Detailed Description

 The protein cfrB of Campylobacter jejuni subsp. jejuni NCTC 11168 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Sequestration of human SLC40A1 substrates/drugs in the health condition [3], [4], [25], [26], [29]

Regulating Factor
ctuA

Detailed Description

 The protein ctuA of Campylobacter jejuni subsp. jejuni NCTC 11168 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence4

 Co-transport of human SLC40A1 substrates/drugs in the health condition [25], [26], [30], [4]

Regulating Factor
feoB

Detailed Description

 The protein feoB of Campylobacter jejuni subsp. jejuni NCTC 11168 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence5

 Sequestration of human SLC40A1 substrates/drugs in the health condition [25], [31], [4]

Regulating Factor
p19

Detailed Description

 The protein p19 of Campylobacter jejuni subsp. jejuni NCTC 11168 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

Bacteria: Cyanobacteriota

   Genus: Synechocystis

     Synechocystis sp. PCC 6803 

Microbe Info

Click to Show/Hide the Full List 4 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [32], [33], [4]

Regulating Factor
futA1

Detailed Description

 The protein futa1 of Synechocystis sp. PCC 6803 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [32], [33], [4]

Regulating Factor
futA2

Detailed Description

 The protein futa2 of Synechocystis sp. PCC 6803 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Sequestration of human SLC40A1 substrates/drugs in the health condition [32], [33], [4]

Regulating Factor
futB

Detailed Description

 The protein futb of Synechocystis sp. PCC 6803 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence4

 Sequestration of human SLC40A1 substrates/drugs in the health condition [32], [34], [4]

Regulating Factor
sll1878

Detailed Description

 The protein sll1878 of Synechocystis sp. PCC 6803 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

Bacteria: Pseudomonadota

   Genus: Acinetobacter

     Acinetobacter baumannii 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [35], [3], [4]

Regulating Factor
tonB3

Detailed Description

 The protein tonB3 of Acinetobacter baumannii ATCC 19606 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Bradyrhizobium

     Bradyrhizobium diazoefficiens 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [17], [36], [4]

Regulating Factor
mnoP

Detailed Description

 The protein mnoP of Bradyrhizobium diazoefficiens USDA 110 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Escherichia

     Escherichia coli 

Microbe Info

Click to Show/Hide the Full List 12 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [32], [37], [3], [4]

Regulating Factor
efeO

Detailed Description

 The protein efeO of Escherichia coli Nissle 1917 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Co-transport of human SLC40A1 substrates/drugs in the health condition [32], [38], [4]

Regulating Factor
efeU

Detailed Description

 The protein efeU of Escherichia coli O157:H7 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence3

 Co-transport of human SLC40A1 substrates/drugs in the health condition [32], [37], [4]

Regulating Factor
efeU

Detailed Description

 The protein efeU of Escherichia coli Nissle 1917 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence4

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [39], [4]

Regulating Factor
fecA

Detailed Description

 The protein fecA of Escherichia coli UT5600 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence5

 Sequestration of human SLC40A1 substrates/drugs in the health condition [15], [40], [4]

Regulating Factor
feoA

Detailed Description

 The protein feoA of Escherichia coli str. K-12 substr. MC4100 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence6

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [40], [4]

Regulating Factor
feoB

Detailed Description

 The protein feoB of Escherichia coli str. K-12 substr. MC4100 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence7

 Co-transport of human SLC40A1 substrates/drugs in the health condition [41], [42], [4]

Regulating Factor
fhuA

Detailed Description

 The protein fhuA of Escherichia coli K-12 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence8

 Co-transport of human SLC40A1 substrates/drugs in the health condition [41], [43], [4]

Regulating Factor
fhuB

Detailed Description

 The protein fhuB of Escherichia coli DH5[alpha] has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence9

 Co-transport of human SLC40A1 substrates/drugs in the health condition [41], [44], [4]

Regulating Factor
fhuC

Detailed Description

 The protein fhuC of Escherichia coli AB2847 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence10

 Sequestration of human SLC40A1 substrates/drugs in the health condition [41], [45], [4]

Regulating Factor
fhuD

Detailed Description

 The protein fhuD of Escherichia coli BL21(DE3) has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence11

 Co-transport of human SLC40A1 substrates/drugs in the health condition [46], [4]

Regulating Factor
IroA , , , ,

Detailed Description

 The protein IroA of Escherichia coli CFT073 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence12

 Sequestration of human SLC40A1 substrates/drugs in the health condition [15], [47], [3], [4]

Regulating Factor
iroN

Detailed Description

 The protein iroN of Escherichia coli O18:H7 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

   Genus: Haemophilus

     Haemophilus influenzae 

Microbe Info

Click to Show/Hide the Full List 3 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [48], [4]

Regulating Factor
FhuCDB , ,

Detailed Description

 The protein FhuCDB of Haemophilus influenzae R2866 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [14], [49]

Regulating Factor
tbpA

Detailed Description

 The protein tbpA of Haemophilus influenzae type b has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [14], [49]

Regulating Factor
tbpB

Detailed Description

 The protein tbpB of Haemophilus influenzae type b has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

   Genus: Klebsiella

     Klebsiella pneumoniae 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [32], [50], [4]

Regulating Factor
feoC

Detailed Description

 The protein feoc of Klebsiella pneumoniae has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Moraxella

     Moraxella catarrhalis 

Microbe Info

Click to Show/Hide the Full List 4 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [10], [51], [3], [4]

Regulating Factor
lbpA

Detailed Description

 The protein lbpa of Moraxella catarrhalis has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [10], [51], [3], [4]

Regulating Factor
lbpB

Detailed Description

 The protein lbpb of Moraxella catarrhalis has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Sequestration of human SLC40A1 substrates/drugs in the health condition [10], [51], [3], [4]

Regulating Factor
tbpA

Detailed Description

 The protein tbpa of Moraxella catarrhalis has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence4

 Sequestration of human SLC40A1 substrates/drugs in the health condition [10], [51], [3], [4]

Regulating Factor
tbpB

Detailed Description

 The protein tbpb of Moraxella catarrhalis has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

   Genus: Neisseria

     Neisseria gonorrhoeae 

Microbe Info

Click to Show/Hide the Full List 3 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [15], [52], [3], [4]

Regulating Factor
lbpA

Detailed Description

 The protein lbpA of Neisseria gonorrhoeae FA19 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [14], [49]

Regulating Factor
tbpA

Detailed Description

 The protein tbpa of Neisseria gonorrhoeae has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [14], [49]

Regulating Factor
tbpB

Detailed Description

 The protein tbpb of Neisseria gonorrhoeae has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

     Neisseria meningitidis 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [14], [49]

Regulating Factor
tbp1

Detailed Description

 The protein tbp1 of Neisseria meningitidis has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [1], [3], [4], [14], [49]

Regulating Factor
tbpB

Detailed Description

 The protein tbpb of Neisseria meningitidis has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

   Genus: Pseudomonas

     Pseudomonas aeruginosa 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [53], [3], [4]

Regulating Factor
tonB

Detailed Description

 The protein tonB of Pseudomonas aeruginosa K199 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [54], [3], [4]

Regulating Factor
TonB1

Detailed Description

 The protein TonB1 of Pseudomonas aeruginosa K1040 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

   Genus: Salmonella

     Salmonella enterica 

Microbe Info

Click to Show/Hide the Full List 10 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [55], [56], [4]

Regulating Factor
Ferrioxamine B

Detailed Description

 The compound Ferrioxamine B Secreted by Salmonella enterica subsp. enterica serovar Typhimurium str. ATCC 14028 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [55], [56], [4]

Regulating Factor
Ferrioxamine E

Detailed Description

 The compound Ferrioxamine E Secreted by Salmonella enterica subsp. enterica serovar Typhimurium str. ATCC 14028 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Sequestration of human SLC40A1 substrates/drugs in the health condition [55], [56], [4]

Regulating Factor
Ferrioxamine G1

Detailed Description

 The compound Ferrioxamine G1 Secreted by Salmonella enterica subsp. enterica serovar Typhimurium str. ATCC 14028 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence4

 Co-transport of human SLC40A1 substrates/drugs in the health condition [57], [58], [3], [4]

Regulating Factor
fepD

Studied Tissue

 Intestine

In Vivo Model

 C3H/HeOuJ mice

Detailed Description

 The protein fepD of Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence5

 Co-transport of human SLC40A1 substrates/drugs in the health condition [32], [59], [4]

Regulating Factor
feoA

Detailed Description

 The protein feoA of Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence6

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [60], [4]

Regulating Factor
feoB

Detailed Description

 The protein feoB of Salmonella enterica subsp. enterica serovar Typhimurium str. ATCC 14028 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence7

 Sequestration of human SLC40A1 substrates/drugs in the health condition [32], [59], [4]

Regulating Factor
feoB

Detailed Description

 The protein feoB of Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence8

 Co-transport of human SLC40A1 substrates/drugs in the health condition [32], [59], [4]

Regulating Factor
feoC

Detailed Description

 The protein feoC of Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence9

 Co-transport of human SLC40A1 substrates/drugs in the health condition [57], [58], [4]

Regulating Factor
SitABCD , , ,

Detailed Description

 The protein SitABCD of Salmonella enterica subsp. enterica serovar Typhimurium JF2043 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence10

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [60], [3], [4]

Regulating Factor
tonB

Detailed Description

 The protein tonB of Salmonella enterica subsp. enterica serovar Typhimurium str. ATCC 14028 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Serratia

     Serratia marcescens 

Microbe Info

Click to Show/Hide the Full List 3 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [32], [33], [61], [4]

Regulating Factor
sfuA

Detailed Description

 The protein sfua of Serratia marcescens has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Co-transport of human SLC40A1 substrates/drugs in the health condition [32], [33], [61], [4]

Regulating Factor
sfuB

Detailed Description

 The protein sfub of Serratia marcescens has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence3

 Co-transport of human SLC40A1 substrates/drugs in the health condition [32], [33], [61], [4]

Regulating Factor
sfuC

Detailed Description

 The protein sfuc of Serratia marcescens has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Shigella

     Shigella flexneri 

Microbe Info

Click to Show/Hide the Full List 4 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [15], [62], [4]

Regulating Factor
fec

Detailed Description

 The protein fec of Shigella flexneri 2a has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [63], [4]

Regulating Factor
feoB

Detailed Description

 The protein feoB of Shigella flexneri SA100 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence3

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [63], [4]

Regulating Factor
sitA

Detailed Description

 The protein sitA of Shigella flexneri SA100 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence4

 Co-transport of human SLC40A1 substrates/drugs in the health condition [17], [18], [63], [4]

Regulating Factor
SitABCD , , ,

Detailed Description

 The protein SitABCD of Shigella flexneri SA100 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Vibrio

     Vibrio anguillarum 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [55], [64], [4]

Regulating Factor
fatA

Detailed Description

 The protein fata of Vibrio anguillarum 775 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC40A1 substrates/drugs in the health condition [55], [64], [4]

Regulating Factor
fatB

Detailed Description

 The protein fatb of Vibrio anguillarum 775 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

     Vibrio cholerae 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [65], [4]

Regulating Factor
Fbp

Detailed Description

 The protein Fbp of Vibrio cholerae O395 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [65], [4]

Regulating Factor
feo

Detailed Description

 The protein feo of Vibrio cholerae O395 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Yersinia

     Yersinia enterocolitica 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [55], [66], [4]

Regulating Factor
fyuA

Detailed Description

 The protein fyuA of Yersinia enterocolitica WA-C has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

     Yersinia pestis 

Microbe Info

Click to Show/Hide the Full List 5 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in pneumonic plague condition [67], [4]

Regulating Factor
feo

Studied Phenotype

 Pneumonic plague [ICD11: 1B93.2]

Studied Tissue

 Lung

In Vivo Model

 Swiss Webster mice

Detailed Description

 The protein feo of Yersinia pestis KIM6 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Sequestration of human SLC40A1 substrates/drugs in the health condition [15], [68], [4]

Regulating Factor
psn

Studied Tissue

 Lung

In Vivo Model

 Swiss Webster mice

Detailed Description

 The protein psn of Yersinia pestis KIM5 has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Co-transport of human SLC40A1 substrates/drugs in the health condition [15], [69], [4]

Regulating Factor
YfeAB ,

Studied Tissue

 Blood

In Vivo Model

 Swiss Webster mice

Detailed Description

 The protein YfeAB of Yersinia pestis KIM5 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence4

 Co-transport of human SLC40A1 substrates/drugs in the health condition [67], [4]

Regulating Factor
YfeABCD , , ,

Studied Tissue

 Lung

In Vivo Model

 Swiss Webster mice

Detailed Description

 The protein YfeABCD of Yersinia pestis KIM6 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence5

 Co-transport of human SLC40A1 substrates/drugs in the health condition [17], [18], [69], [4]

Regulating Factor
YfeABCD , , ,

Detailed Description

 The protein YfeABCD of Yersinia pestis KIM5-2031.11+ has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

Bacteria: Spirochaetota

   Genus: Treponema

     Treponema pallidum 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC40A1 substrates/drugs in the health condition [70], [3], [4]

Regulating Factor
troA

Detailed Description

 The protein troA of Treponema pallidum subsp. pallidum str. Nichols has been reported to sequester the substrate/drug of SLC40A1, which may affects its substrate/drug distribution in the body.

Fungi: Ascomycota

   Genus: Candida

     Candida albicans 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC40A1 substrates/drugs in the health condition [57], [71], [3], [4]

Regulating Factor
Sit1p

Studied Tissue

 Blood

In Vivo Model

 BALB/c mice

Detailed Description

 The protein Sit1p of Candida albicans CAF2-1 has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC40A1 substrates/drugs in the health condition [57], [72], [4]

Regulating Factor
CaFTR1

Detailed Description

 The protein caftr1 of Candida albicans has been reported to transport similar substrates/drugs of SLC40A1, which affects the distribution of its substrate/drug in vivo.

Bacteria: Host unspecified microbiota

   Genus: Unknown microbiota

     Host unspecified microbiota 

Click to Show/Hide the Full List 4 Microbe Influence Related to This Species      

       Microbe Influence1

 Down regulating of SLC40A1 expression in clostridium difficile infection condition [73]

Regulating Factor
urolithin A

Studied Phenotype

 Colitis [ICD11: 1A40.0]

In Vitro Model

 HT29 cells

Detailed Description

 The metabolite urolithin A generated from the metabolism of dietary precursors by the host unspecified microbiota has been reported to downregulate the expression of the drug transporter SLC40A1.

       Microbe Influence2

 Up regulating of SLC40A1 expression in anemia condition [74]

Regulating Factor
Short-chain fatty acid (Acetate)

Studied Phenotype

 Anemia [ICD11: 3A01.30]

Studied Tissue

 Duodenum

In Vivo Model

 Yorkshire-Hampshire-Landrace hybrid pigs

Detailed Description

 The metabolite short-chain fatty acid (acetate) generated from the metabolism of dietary inulin by the host unspecified microbiota has been reported to increase the expression of the drug transporter SLC40A1.

       Microbe Influence3

 Up regulating of SLC40A1 expression in anemia condition [74]

Regulating Factor
Short-chain fatty acid (Butyrate)

Studied Phenotype

 Anemia [ICD11: 3A01.30]

Studied Tissue

 Duodenum

In Vivo Model

 Yorkshire-Hampshire-Landrace hybrid pigs

Detailed Description

 The metabolite short-chain fatty acid (butyrate) generated from the metabolism of dietary inulin by the host unspecified microbiota has been reported to increase the expression of the drug transporter SLC40A1.

       Microbe Influence4

 Up regulating of SLC40A1 expression in anemia condition [74]

Regulating Factor
Short-chain fatty acid (Propionate)

Studied Phenotype

 Anemia [ICD11: 3A01.30]

Studied Tissue

 Duodenum

In Vivo Model

 Yorkshire-Hampshire-Landrace hybrid pigs

Detailed Description

 The metabolite short-chain fatty acid (propionate) generated from the metabolism of dietary inulin by the host unspecified microbiota has been reported to increase the expression of the drug transporter SLC40A1.
References
1 Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin. Nat Commun. 2014 Aug 28;5:4730.
2 Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall. J Exp Med. 1996 Apr 1;183(4):1527-32.
3 Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence. Front Cell Infect Microbiol. 2013 Dec 5;3:90.
4 Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
5 The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain. J Bacteriol. 2010 Feb;192(3):861-9.
6 Metallobiology of Lactobacillaceae in the gut microbiome. J Inorg Biochem. 2023 Jan;238:112023.
7 Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis. Cell Metab. 2020 Jan 7;31(1):115-130.e6.
8 Siderophore-mediated iron acquisition in the staphylococci. J Inorg Biochem. 2010 Mar;104(3):282-8.
9 FhuD1, a ferric hydroxamate-binding lipoprotein in Staphylococcus aureus: a case of gene duplication and lateral transfer. J Biol Chem. 2004 Dec 17;279(51):53152-9.
10 The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota. Nat Rev Microbiol. 2017 Oct 12;15(11):675-687.
11 The role of FhuD2 in iron(III)-hydroxamate transport in Staphylococcus aureus. Demonstration that FhuD2 binds iron(III)-hydroxamates but with minimal conformational change and implication of mutations on transport. J Biol Chem. 2003 Dec 12;278(50):49890-900.
12 Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus. Mol Microbiol. 2009 May;72(4):947-63.
13 Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein. Mol Microbiol. 2002 Mar;43(6):1603-14.
14 The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase. Infect Immun. 1999 Mar;67(3):1086-92.
15 Sequestration and scavenging of iron in infection. Infect Immun. 2013 Oct;81(10):3503-14.
16 Staphylococci express a receptor for human transferrin: identification of a 42-kilodalton cell wall transferrin-binding protein. Infect Immun. 1994 Sep;62(9):3850-8.
17 Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
18 Manganese transport and the role of manganese in virulence. Annu Rev Microbiol. 2006;60:187-209.
19 MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake. Mol Microbiol. 2002 Jun;44(5):1269-86.
20 Involvement of SirABC in iron-siderophore import in Staphylococcus aureus. J Bacteriol. 2004 Dec;186(24):8356-62.
21 Molecular cloning and analysis of a putative siderophore ABC transporter from Staphylococcus aureus. Infect Immun. 2000 Nov;68(11):6281-8.
22 Evidence for siderophore-dependent iron acquisition in group B streptococcus. Mol Microbiol. 2006 Jan;59(2):707-21.
23 A new family of high-affinity ABC manganese and zinc permeases. Res Microbiol. 2001 Apr-May;152(3-4):231-43.
24 Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus. Infect Immun. 2000 Oct;68(10):6048-51.
25 Metal homeostasis in pathogenic Epsilonproteobacteria: mechanisms of acquisition, efflux, and regulation. Metallomics. 2021 Jan 16;13(1):mfaa002.
26 Nutrient acquisition and metabolism by Campylobacter jejuni. Front Cell Infect Microbiol. 2012 Feb 7;2:5.
27 Identification and characterization of a new ferric enterobactin receptor, CfrB, in Campylobacter. J Bacteriol. 2010 Sep;192(17):4425-35.
28 Iron acquisition and regulation in Campylobacter jejuni. J Bacteriol. 2004 Jul;186(14):4714-29.
29 Utilization of lactoferrin-bound and transferrin-bound iron by Campylobacter jejuni. J Bacteriol. 2008 Mar;190(6):1900-11.
30 Major role for FeoB in Campylobacter jejuni ferrous iron acquisition, gut colonization, and intracellular survival. Infect Immun. 2006 Oct;74(10):5433-44.
31 Structure and function of P19, a high-affinity iron transporter of the human pathogen Campylobacter jejuni. J Mol Biol. 2010 Aug 27;401(4):590-604.
32 Bacterial ferrous iron transport: the Feo system. FEMS Microbiol Rev. 2016 Mar;40(2):273-98.
33 Iron-binding activity of FutA1 subunit of an ABC-type iron transporter in the cyanobacterium Synechocystis sp. Strain PCC 6803. Plant Cell Physiol. 2001 Aug;42(8):823-7.
34 Genes essential to iron transport in the cyanobacterium Synechocystis sp. strain PCC 6803. J Bacteriol. 2001 May;183(9):2779-84.
35 Contribution of Active Iron Uptake to Acinetobacter baumannii Pathogenicity. Infect Immun. 2019 Mar 25;87(4):e00755-18.
36 Bacterial outer membrane channel for divalent metal ion acquisition. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15390-5.
37 A new ferrous iron-uptake transporter, EfeU (YcdN), from Escherichia coli. Mol Microbiol. 2006 Oct;62(1):120-31.
38 EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in E. coli O157:H7. Mol Microbiol. 2007 Aug;65(4):857-75.
39 Structural basis of gating by the outer membrane transporter FecA. Science. 2002 Mar 1;295(5560):1715-9.
40 Characterization of the ferrous iron uptake system of Escherichia coli. J Bacteriol. 1993 Oct;175(19):6212-9.
41 Iron uptake mechanisms and their regulation in pathogenic bacteria. Int J Med Microbiol. 2001 May;291(2):67-79.
42 Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide. Science. 1998 Dec 18;282(5397):2215-20.
43 Transmembrane topology of the two FhuB domains representing the hydrophobic components of bacterial ABC transporters involved in the uptake of siderophores, haem and vitamin B12. Microbiology (Reading). 1998 Oct;144 ( Pt 10):2759-2769.
44 Iron(III) hydroxamate transport in Escherichia coli K-12: FhuB-mediated membrane association of the FhuC protein and negative complementation of fhuC mutants. J Bacteriol. 1992 Apr;174(7):2305-11.
45 The structure of the ferric siderophore binding protein FhuD complexed with gallichrome. Nat Struct Biol. 2000 Apr;7(4):287-91.
46 The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16502-7.
47 The siderophore receptor IroN, but not the high-pathogenicity island or the hemin receptor ChuA, contributes to the bacteremic step of Escherichia coli neonatal meningitis. Infect Immun. 2004 Feb;72(2):1216-20.
48 Identification of a siderophore utilization locus in nontypeable Haemophilus influenzae. BMC Microbiol. 2010 Apr 15;10:113.
49 Iron piracy: acquisition of transferrin-bound iron by bacterial pathogens. Mol Microbiol. 1994 Dec;14(5):843-50.
50 NMR structure note: the ferrous iron transport protein C (FeoC) from Klebsiella pneumoniae. J Biomol NMR. 2012 Jun;53(2):161-5.
51 Moraxella catarrhalis: a review of an important human mucosal pathogen. Microbes Infect. 2000 Apr;2(5):547-59.
52 Characterization of lbpA, the structural gene for a lactoferrin receptor in Neisseria gonorrhoeae. Infect Immun. 1995 Aug;63(8):2958-67.
53 The Pseudomonas aeruginosa tonB gene encodes a novel TonB protein. Microbiology (Reading). 1996 Jun;142 ( Pt 6):1449-1458.
54 Mutational analysis of the TonB1 energy coupler of Pseudomonas aeruginosa. J Bacteriol. 2002 Mar;184(6):1503-13.
55 Iron metabolism in pathogenic bacteria. Annu Rev Microbiol. 2000;54:881-941.
56 Ferrioxamine-mediated Iron(III) utilization by Salmonella enterica. Appl Environ Microbiol. 1999 Apr;65(4):1610-8.
57 Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
58 Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium. Mol Microbiol. 2008 Mar;67(5):971-83.
59 Lon-mediated proteolysis of the FeoC protein prevents Salmonella enterica from accumulating the Fe(II) transporter FeoB under high-oxygen conditions. J Bacteriol. 2015 Jan 1;197(1):92-8.
60 Contribution of TonB- and Feo-mediated iron uptake to growth of Salmonella typhimurium in the mouse. Infect Immun. 1996 Nov;64(11):4549-56.
61 Nucleotide sequences of the sfuA, sfuB, and sfuC genes of Serratia marcescens suggest a periplasmic-binding-protein-dependent iron transport mechanism. J Bacteriol. 1990 Feb;172(2):572-8.
62 Ferric dicitrate transport system (Fec) of Shigella flexneri 2a YSH6000 is encoded on a novel pathogenicity island carrying multiple antibiotic resistance genes. Infect Immun. 2001 Oct;69(10):6012-21.
63 Contribution of the Shigella flexneri Sit, Iuc, and Feo iron acquisition systems to iron acquisition in vitro and in cultured cells. Infect Immun. 2003 Apr;71(4):1919-28.
64 The AngR protein and the siderophore anguibactin positively regulate the expression of iron-transport genes in Vibrio anguillarum. Mol Microbiol. 1996 Oct;22(1):127-34.
65 Characterization of ferric and ferrous iron transport systems in Vibrio cholerae. J Bacteriol. 2006 Sep;188(18):6515-23.
66 Purification of yersiniabactin: a siderophore and possible virulence factor of Yersinia enterocolitica. J Gen Microbiol. 1993 Sep;139(9):2159-65.
67 The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague. Infect Immun. 2012 Nov;80(11):3880-91.
68 The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague. Infect Immun. 2010 May;78(5):2045-52.
69 The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague. Mol Microbiol. 1999 Apr;32(2):403-14.
70 The general transition metal (Tro) and Zn2+ (Znu) transporters in Treponema pallidum: analysis of metal specificities and expression profiles. Mol Microbiol. 2007 Jul;65(1):137-52.
71 The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion. Infect Immun. 2002 Sep;70(9):5246-55.
72 A high-affinity iron permease essential for Candida albicans virulence. Science. 2000 May 12;288(5468):1062-4.
73 Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat Commun. 2019 Jan 9;10(1):89.
74 Dietary inulin affects the expression of intestinal enterocyte iron transporters, receptors and storage protein and alters the microbiota in the pig intestine. Br J Nutr. 2008 Mar;99(3):472-80.

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