Microbe Species Information

General Information of This Microbe species
Species ID	MIC00103
Species Name	Yersinia pestis
Taxonomy ID	632
Lineage	Kingdom:Bacteria Phylum:Pseudomonadota Class:Gammaproteobacteria Order:Enterobacterales Family:Yersiniaceae Genus: Yersinia Species: Yersinia pestis

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
CACNA1A	Transporter Info	Pneumonic plague [ICD11: 1B93.2]	[1], [2]
COPT2	Transporter Info	Leukemia [ICD11: 2A60-2B33]	[3], [4], [5], [6]
CTR1	Transporter Info	Leukemia [ICD11: 2A60-2B33]	[3], [4], [5], [6]
IREG1	Transporter Info	Pneumonic plague [ICD11: 1B93.2]	[1], [2]
NRAMP2	Transporter Info	Pneumonic plague [ICD11: 1B93.2]	[1], [2]
SLC11A1	Transporter Info	Pneumonic plague [ICD11: 1B93.2]	[7], [8], [9], [10]
SLC25A28	Transporter Info	Pneumonic plague [ICD11: 1B93.2]	[1], [2]
SLC25A37	Transporter Info	Pneumonic plague [ICD11: 1B93.2]	[1], [2]
SLC41A1	Transporter Info	Health [ICD11: N.A]	[11], [12], [13]
SLC58A1	Transporter Info	Health [ICD11: N.A]	[11], [12], [13]
ZIP1	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP10	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP11	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP12	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP13	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP14	Transporter Info	Pneumonic plague [ICD11: 1B93.2]	[1], [2]
ZIP2	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP3	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP4	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP5	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP6	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP7	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]
ZIP8	Transporter Info	Pneumonic plague [ICD11: 1B93.2]	[1], [2]
ZIP9	Transporter Info	Septicemic plague [ICD11: 1B93]	[14], [15], [16]

References
1	The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague. Infect Immun. 2012 Nov;80(11):3880-91.
2	Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
3	Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper. Anim Nutr. 2021 Sep;7(3):750-761.
4	Cu Homeostasis in Bacteria: The Ins and Outs. Membranes (Basel). 2020 Sep 18;10(9):242.
5	Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic. ACS Chem Biol. 2014 Feb 21;9(2):551-61.
6	Human copper transporters: mechanism, role in human diseases and therapeutic potential. Future Med Chem. 2009 Sep;1(6):1125-42.
7	Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
8	Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis. Microbiology (Reading). 2012 Mar;158(Pt 3):804-815.
9	Human iron transporters. Genes Nutr. 2011 Feb;6(1):45-54.
10	Iron transport machinery of human cells: players and their interactions. Curr Top Membr. 2012;69:67-93.
11	Transcription factor function and promoter architecture govern the evolution of bacterial regulons. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4319-24.
12	The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):620-8.
13	The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. J Biol Chem. 1999 Jul 16;274(29):20438-43.
14	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
15	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.
16	The Yersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice. Mol Microbiol. 2014 Aug;93(4):759-75.

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