Microbe Species Information

General Information of This Microbe species
Species ID	MIC00047
Species Name	Mycobacterium tuberculosis
Taxonomy ID	1773
Lineage	Kingdom:Bacteria Phylum:Actinomycetota Class:Actinomycetes Order:Mycobacteriales Family:Mycobacteriaceae Genus: Mycobacterium Species: Mycobacterium tuberculosis

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
ATP7A	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
ATP7B	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
CACNA1A	Transporter Info	Health [ICD11: N.A]	[5], [6], [7]
COPT2	Transporter Info	Health [ICD11: N.A]	[2], [4], [8], [9], [10]
CTR1	Transporter Info	Health [ICD11: N.A]	[2], [4], [8], [9], [10]
FLVCR1	Transporter Info	Health [ICD11: N.A]	[11], [12], [13], [14]
IREG1	Transporter Info	Health [ICD11: N.A]	[5], [15], [16], [7]
NRAMP2	Transporter Info	Health [ICD11: N.A]	[5], [17], [18], [19]
SLC11A1	Transporter Info	Health [ICD11: N.A]	[5], [17], [18], [19]
SLC25A28	Transporter Info	Health [ICD11: N.A]	[5], [15], [16], [7]
SLC25A37	Transporter Info	Health [ICD11: N.A]	[5], [15], [16], [7]
SLC48A1	Transporter Info	Health [ICD11: N.A]	[11], [12], [13], [14]
SLC49A2	Transporter Info	Health [ICD11: N.A]	[11], [12], [13], [14]
ZIP14	Transporter Info	Health [ICD11: N.A]	[5], [15], [16], [7]
ZIP8	Transporter Info	Health [ICD11: N.A]	[5], [6], [7]
ZNT1	Transporter Info	Health [ICD11: N.A]	[20], [1], [21], [3]

References
1	Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Arch Biochem Biophys. 2016 Dec 1;611:66-78.
2	Cu Homeostasis in Bacteria: The Ins and Outs. Membranes (Basel). 2020 Sep 18;10(9):242.
3	A novel P(1B)-type Mn2+-transporting ATPase is required for secreted protein metallation in mycobacteria. J Biol Chem. 2013 Apr 19;288(16):11334-47.
4	Human copper transporters: mechanism, role in human diseases and therapeutic potential. Future Med Chem. 2009 Sep;1(6):1125-42.
5	Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin. Nat Commun. 2014 Aug 28;5:4730.
6	The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain. J Bacteriol. 2010 Feb;192(3):861-9.
7	Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
8	Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
9	Manganese transport and the role of manganese in virulence. Annu Rev Microbiol. 2006;60:187-209.
10	Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family. J Exp Med. 1999 Sep 6;190(5):717-24.
11	A battle for iron: host sequestration and Staphylococcus aureus acquisition. Microbes Infect. 2012 Mar;14(3):217-27.
12	Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis. J Mol Biol. 2010 Jan 22;395(3):595-608.
13	Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res. 2016 Jun 21;49(6):1104-10.
14	Handling heme: The mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019 Mar;133:88-100.
15	Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall. J Exp Med. 1996 Apr 1;183(4):1527-32.
16	Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence. Front Cell Infect Microbiol. 2013 Dec 5;3:90.
17	Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system. J Immunol. 2005 Feb 1;174(3):1491-500.
18	Human iron transporters. Genes Nutr. 2011 Feb;6(1):45-54.
19	Iron transport machinery of human cells: players and their interactions. Curr Top Membr. 2012;69:67-93.
20	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
21	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.

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