Microbe Species Information | VARIDT

General Information of This Microbe species
Species ID	MIC00031
Species Name	Haemophilus influenzae
Taxonomy ID	727
Lineage	Kingdom:Bacteria Phylum:Pseudomonadota Class:Gammaproteobacteria Order:Pasteurellales Family:Pasteurellaceae Genus: Haemophilus Species: Haemophilus influenzae

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
CACNA1A	Transporter Info	Health [ICD11: N.A]			[1], [2], [3]
FLVCR1	Transporter Info	Health [ICD11: N.A]			[4], [5], [6], [7], [8]
IREG1	Transporter Info	Health [ICD11: N.A]			[1], [2], [3]
NRAMP2	Transporter Info	Health [ICD11: N.A]			[1], [2], [3]
SLC25A28	Transporter Info	Health [ICD11: N.A]			[1], [2], [3]
SLC25A37	Transporter Info	Health [ICD11: N.A]			[1], [2], [3]
SLC48A1	Transporter Info	Health [ICD11: N.A]			[1], [9], [7], [8]
SLC49A2	Transporter Info	Health [ICD11: N.A]			[1], [9], [7], [8]
ZIP1	Transporter Info	Health [ICD11: N.A]			[10], [11], [12], [13]
ZIP14	Transporter Info	Health [ICD11: N.A]			[1], [2], [3]
ZIP8	Transporter Info	Health [ICD11: N.A]			[1], [2], [3]

Species Relative Abundances of This Microbe species

References
1	Sequestration and scavenging of iron in infection. Infect Immun. 2013 Oct;81(10):3503-14.
2	Identification of a siderophore utilization locus in nontypeable Haemophilus influenzae. BMC Microbiol. 2010 Apr 15;10:113.
3	Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
4	Bacterial ferrous iron transport: the Feo system. FEMS Microbiol Rev. 2016 Mar;40(2):273-98.
5	Iron-binding activity of FutA1 subunit of an ABC-type iron transporter in the cyanobacterium Synechocystis sp. Strain PCC 6803. Plant Cell Physiol. 2001 Aug;42(8):823-7.
6	Identification of a locus involved in the utilization of iron by Haemophilus influenzae. Infect Immun. 1994 Oct;62(10):4515-25.
7	Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res. 2016 Jun 21;49(6):1104-10.
8	Handling heme: The mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019 Mar;133:88-100.
9	The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant. Int J Med Microbiol. 2009 Nov;299(7):479-88.
10	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
11	A new family of high-affinity ABC manganese and zinc permeases. Res Microbiol. 2001 Apr-May;152(3-4):231-43.
12	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.
13	Identification of the key protein for zinc uptake in Hemophilus influenzae. J Biol Chem. 1997 Nov 14;272(46):29033-8.

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